HRP20100227T1 - Stanice domaćini tumora preuređene da proizvode ligand koji inducira apoptozu povezanu s faktorom nekroze tumora (trail) - Google Patents

Stanice domaćini tumora preuređene da proizvode ligand koji inducira apoptozu povezanu s faktorom nekroze tumora (trail) Download PDF

Info

Publication number
HRP20100227T1
HRP20100227T1 HR20100227T HRP20100227T HRP20100227T1 HR P20100227 T1 HRP20100227 T1 HR P20100227T1 HR 20100227 T HR20100227 T HR 20100227T HR P20100227 T HRP20100227 T HR P20100227T HR P20100227 T1 HRP20100227 T1 HR P20100227T1
Authority
HR
Croatia
Prior art keywords
tumor
cells
trail
household
stations
Prior art date
Application number
HR20100227T
Other languages
English (en)
Croatian (hr)
Inventor
M. Gianni Alessandro
Carlo-Stella Carmelo
Colotta Francesco
Original Assignee
Dompe' S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe' S.P.A. filed Critical Dompe' S.P.A.
Publication of HRP20100227T1 publication Critical patent/HRP20100227T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4231—Cytokines
    • A61K40/4232—Tumor necrosis factors [TNF] or CD70
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HR20100227T 2004-07-29 2005-07-21 Stanice domaćini tumora preuređene da proizvode ligand koji inducira apoptozu povezanu s faktorom nekroze tumora (trail) HRP20100227T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017907A EP1621550A1 (en) 2004-07-29 2004-07-29 Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
PCT/EP2005/007957 WO2006010558A1 (en) 2004-07-29 2005-07-21 Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (trail)

Publications (1)

Publication Number Publication Date
HRP20100227T1 true HRP20100227T1 (hr) 2010-07-31

Family

ID=34925971

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100227T HRP20100227T1 (hr) 2004-07-29 2005-07-21 Stanice domaćini tumora preuređene da proizvode ligand koji inducira apoptozu povezanu s faktorom nekroze tumora (trail)

Country Status (24)

Country Link
US (1) US20070264231A1 (cg-RX-API-DMAC7.html)
EP (2) EP1621550A1 (cg-RX-API-DMAC7.html)
JP (1) JP5042826B2 (cg-RX-API-DMAC7.html)
KR (1) KR20070047757A (cg-RX-API-DMAC7.html)
CN (1) CN101076540B (cg-RX-API-DMAC7.html)
AT (1) ATE455847T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005266543B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0513855A (cg-RX-API-DMAC7.html)
CA (1) CA2571426A1 (cg-RX-API-DMAC7.html)
DE (1) DE602005019050D1 (cg-RX-API-DMAC7.html)
DK (1) DK1771468T3 (cg-RX-API-DMAC7.html)
ES (1) ES2340400T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20100227T1 (cg-RX-API-DMAC7.html)
IL (1) IL180233A (cg-RX-API-DMAC7.html)
MX (1) MX2007001152A (cg-RX-API-DMAC7.html)
NO (1) NO20070956L (cg-RX-API-DMAC7.html)
NZ (1) NZ552223A (cg-RX-API-DMAC7.html)
PL (1) PL1771468T3 (cg-RX-API-DMAC7.html)
PT (1) PT1771468E (cg-RX-API-DMAC7.html)
RS (1) RS51381B (cg-RX-API-DMAC7.html)
RU (1) RU2390558C2 (cg-RX-API-DMAC7.html)
SI (1) SI1771468T1 (cg-RX-API-DMAC7.html)
WO (1) WO2006010558A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200701231B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06014784A (es) * 2004-06-18 2007-04-25 Genentech Inc Metodos para utilizar agonistas del receptor apo-2l y actividadores de celulas nk.
DE102006020307A1 (de) * 2006-05-03 2007-11-08 Martin-Luther-Universität Halle-Wittenberg TNF-related apoptosis-including (TRAIL)stabil transgen exprimierende mesenchymale Stammzellen, Verfahren zu ihrer Herstellung und zu ihrer Verwendung
EP2163250B1 (en) * 2007-05-18 2013-01-09 National University Corporation Asahikawa Medical University Anticancer therapy by transplanting vascular endothelial progenitor cells
CN102154213B (zh) * 2011-01-19 2012-07-25 郑骏年 一种运载荷载细胞因子的双调控溶瘤腺病毒的新型cik细胞
CN105950630A (zh) * 2012-02-01 2016-09-21 浦项工科大学校产学协力团 同时表达十二聚体trail及hsv-tk自杀基因的载体及利用其的抗癌干细胞治疗剂
CN103288966B (zh) * 2013-05-17 2015-01-21 华侨大学 一种融合受体及其用于治疗大肠癌的基因药物
RU2552609C1 (ru) * 2013-10-28 2015-06-10 Федеральное государственное бюджетное учреждение науки Институт молекулярной биотехнологии им. В.А. Энгельгардта Российской академии наук (ИМБ РАН) Способ получения системы направленной доставки белковых молекул (онколитических белков) в опухолевые ткани на основе активированных лимфоцитов
CA3003133C (en) 2014-10-24 2020-09-15 StemImmune, Incorporated Combination immunotherapy approach for treatment of cancer
ES2970269T3 (es) * 2015-07-29 2024-05-27 Onk Therapeutics Ltd Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada
US10906951B2 (en) * 2015-07-29 2021-02-02 Onk Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
WO2019232631A1 (en) * 2018-06-06 2019-12-12 Stemcell Technologies Canada Inc. Kits, compositions and methods for myeloid-derived suppressor cell enrichment
US12220465B2 (en) 2018-11-28 2025-02-11 Washington University Compositions and methods for targeted treatment and imaging of cancer or tumors
KR20210142665A (ko) 2019-03-21 2021-11-25 오엔케이 테라퓨틱스 리미티드 세포 사멸에 대한 증가된 내성을 갖는 변형된 면역 효과기 세포
EP3712257A1 (en) 2019-03-21 2020-09-23 ONK Therapeutics Limited Modified natural killer cells with increased resistance to cell death
WO2021209625A1 (en) 2020-04-17 2021-10-21 Onk Therapeutics Limited High potency natural killer cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879672A (en) * 1994-10-07 1999-03-09 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 1
WO1998055607A2 (en) * 1997-06-04 1998-12-10 Oxford Biomedica (Uk) Limited Tumor targeted vector
CN1744919A (zh) * 2000-09-11 2006-03-08 南卡罗莱纳医科大学研究发展基金会 使用凋亡的选择性诱导来治疗肿瘤的方法和组合物
JP2004529102A (ja) * 2000-10-24 2004-09-24 イミュネックス・コーポレーション 併用療法を用いて、腫瘍を治療する方法
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
JP4493882B2 (ja) * 2001-06-19 2010-06-30 株式会社カネカ 抗原およびこの抗原を識別するモノクローナル抗体

Also Published As

Publication number Publication date
EP1771468B1 (en) 2010-01-20
DE602005019050D1 (de) 2010-03-11
BRPI0513855A (pt) 2008-05-20
IL180233A0 (en) 2007-07-04
AU2005266543A1 (en) 2006-02-02
JP5042826B2 (ja) 2012-10-03
US20070264231A1 (en) 2007-11-15
RS51381B (sr) 2011-02-28
JP2008507961A (ja) 2008-03-21
NO20070956L (no) 2007-02-20
PT1771468E (pt) 2010-04-20
CN101076540B (zh) 2012-10-24
EP1621550A1 (en) 2006-02-01
RU2390558C2 (ru) 2010-05-27
PL1771468T3 (pl) 2010-07-30
IL180233A (en) 2010-12-30
CA2571426A1 (en) 2006-02-02
SI1771468T1 (sl) 2010-07-30
EP1771468A1 (en) 2007-04-11
MX2007001152A (es) 2007-04-18
NZ552223A (en) 2009-01-31
ATE455847T1 (de) 2010-02-15
RU2007107369A (ru) 2008-09-10
AU2005266543B2 (en) 2012-02-02
ZA200701231B (en) 2008-08-27
WO2006010558A8 (en) 2006-08-24
ES2340400T3 (es) 2010-06-02
HK1110874A1 (en) 2008-07-25
KR20070047757A (ko) 2007-05-07
DK1771468T3 (da) 2010-05-25
WO2006010558A1 (en) 2006-02-02
CN101076540A (zh) 2007-11-21

Similar Documents

Publication Publication Date Title
HRP20100227T1 (hr) Stanice domaćini tumora preuređene da proizvode ligand koji inducira apoptozu povezanu s faktorom nekroze tumora (trail)
Cao et al. Antitumor activity of polysaccharide extracted from Pleurotus ostreatus mycelia against gastric cancer in vitro and in vivo
Ahn et al. Human adipose tissue-derived mesenchymal stem cells inhibit melanoma growth in vitro and in vivo
RU2016102158A (ru) Применение эрибулина и ленватиниба в качестве комбинированной терапии для лечения рака
AR061245A1 (es) Composiciones y metodos para la modulacion del desarrollo vascular
Kamalabadi-Farahani et al. Anti-tumour effects of TRAIL-expressing human placental derived mesenchymal stem cells with curcumin-loaded chitosan nanoparticles in a mice model of triple negative breast cancer
Vu et al. Doxorubicin and 5-fluorouracil resistant hepatic cancer cells demonstrate stem-like properties
Gotoh et al. Antitumor action of α1-adrenoceptor blockers on human bladder, prostate and renal cancer cells
CN111888376B (zh) 一种负载顺铂的纤维蛋白胶复合体系联合治疗系统
JP2008507961A5 (cg-RX-API-DMAC7.html)
Mieville et al. Advanced in vitro models for renal cell carcinoma therapy design
Kutushov et al. Low concentrations of Rhodamine-6G selectively destroy tumor cells and improve survival of melanoma transplanted mice
Satonaka et al. Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma
CN102688493A (zh) 含有白藜芦醇及白藜芦醇类衍生物和Bc1-2抑制剂的药物组合物及其应用
CN106075453A (zh) 一种抗肿瘤药物制剂组合
Lyu et al. Halogen-bridged binuclear iridium (III) complexes with enhanced photodynamic therapeutic effects in mitochondria
CN102688228B (zh) 含有芹菜素及芹菜素类衍生物和冬凌草甲素及冬凌草甲素类衍生物的药物组合物及其应用
Jain et al. Buccal metastasis in a case of carcinoma breast: A rare case report with review of literature
Huang et al. Evidence that high-migration drug-surviving MOLT4 leukemia cells exhibit cancer stem cell-like properties
CN106011071B (zh) 一种原代肿瘤细胞培养组合物及其应用
BRPI0707247A8 (pt) vacina para tumor compreendendo células tumorais alogênicas ou xenogênicas
CN118340779A (zh) 一种高效低毒抗癌联合用药物和药物组合物
CN107349426A (zh) 阿司匹林与曲妥珠单抗联合或协同在肿瘤治疗中的应用
Kaidar-Person et al. Lymphoepithelioma‐Like Carcinoma of the Salivary Gland: Is Radiotherapy Alone Adequate?
CN116850190B (zh) Dorsomorphin在制备治疗膀胱癌药物中的应用