JP2008507961A5 - - Google Patents
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- Publication number
- JP2008507961A5 JP2008507961A5 JP2007522989A JP2007522989A JP2008507961A5 JP 2008507961 A5 JP2008507961 A5 JP 2008507961A5 JP 2007522989 A JP2007522989 A JP 2007522989A JP 2007522989 A JP2007522989 A JP 2007522989A JP 2008507961 A5 JP2008507961 A5 JP 2008507961A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- tumor
- peripheral blood
- necrosis factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 4
- 108700012411 TNFSF10 Proteins 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 210000003810 lymphokine-activated killer cell Anatomy 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 230000002463 transducing effect Effects 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004405 cytokine-induced killer cell Anatomy 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04017907.9 | 2004-07-29 | ||
| EP04017907A EP1621550A1 (en) | 2004-07-29 | 2004-07-29 | Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) |
| PCT/EP2005/007957 WO2006010558A1 (en) | 2004-07-29 | 2005-07-21 | Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (trail) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008507961A JP2008507961A (ja) | 2008-03-21 |
| JP2008507961A5 true JP2008507961A5 (cg-RX-API-DMAC7.html) | 2008-09-11 |
| JP5042826B2 JP5042826B2 (ja) | 2012-10-03 |
Family
ID=34925971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522989A Expired - Fee Related JP5042826B2 (ja) | 2004-07-29 | 2005-07-21 | 腫瘍壊死因子関連アポトーシス誘導リガンド（ｔｒａｉｌ）を産生するように遺伝子操作された腫瘍帰巣細胞 |
Country Status (24)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06014784A (es) * | 2004-06-18 | 2007-04-25 | Genentech Inc | Metodos para utilizar agonistas del receptor apo-2l y actividadores de celulas nk. |
| DE102006020307A1 (de) * | 2006-05-03 | 2007-11-08 | Martin-Luther-Universität Halle-Wittenberg | TNF-related apoptosis-including (TRAIL)stabil transgen exprimierende mesenchymale Stammzellen, Verfahren zu ihrer Herstellung und zu ihrer Verwendung |
| EP2163250B1 (en) * | 2007-05-18 | 2013-01-09 | National University Corporation Asahikawa Medical University | Anticancer therapy by transplanting vascular endothelial progenitor cells |
| CN102154213B (zh) * | 2011-01-19 | 2012-07-25 | 郑骏年 | 一种运载荷载细胞因子的双调控溶瘤腺病毒的新型cik细胞 |
| CN105950630A (zh) * | 2012-02-01 | 2016-09-21 | 浦项工科大学校产学协力团 | 同时表达十二聚体trail及hsv-tk自杀基因的载体及利用其的抗癌干细胞治疗剂 |
| CN103288966B (zh) * | 2013-05-17 | 2015-01-21 | 华侨大学 | 一种融合受体及其用于治疗大肠癌的基因药物 |
| RU2552609C1 (ru) * | 2013-10-28 | 2015-06-10 | Федеральное государственное бюджетное учреждение науки Институт молекулярной биотехнологии им. В.А. Энгельгардта Российской академии наук (ИМБ РАН) | Способ получения системы направленной доставки белковых молекул (онколитических белков) в опухолевые ткани на основе активированных лимфоцитов |
| CA3003133C (en) | 2014-10-24 | 2020-09-15 | StemImmune, Incorporated | Combination immunotherapy approach for treatment of cancer |
| ES2970269T3 (es) * | 2015-07-29 | 2024-05-27 | Onk Therapeutics Ltd | Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada |
| US10906951B2 (en) * | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| WO2019232631A1 (en) * | 2018-06-06 | 2019-12-12 | Stemcell Technologies Canada Inc. | Kits, compositions and methods for myeloid-derived suppressor cell enrichment |
| US12220465B2 (en) | 2018-11-28 | 2025-02-11 | Washington University | Compositions and methods for targeted treatment and imaging of cancer or tumors |
| KR20210142665A (ko) | 2019-03-21 | 2021-11-25 | 오엔케이 테라퓨틱스 리미티드 | 세포 사멸에 대한 증가된 내성을 갖는 변형된 면역 효과기 세포 |
| EP3712257A1 (en) | 2019-03-21 | 2020-09-23 | ONK Therapeutics Limited | Modified natural killer cells with increased resistance to cell death |
| WO2021209625A1 (en) | 2020-04-17 | 2021-10-21 | Onk Therapeutics Limited | High potency natural killer cells |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| WO1998055607A2 (en) * | 1997-06-04 | 1998-12-10 | Oxford Biomedica (Uk) Limited | Tumor targeted vector |
| CN1744919A (zh) * | 2000-09-11 | 2006-03-08 | 南卡罗莱纳医科大学研究发展基金会 | 使用凋亡的选择性诱导来治疗肿瘤的方法和组合物 |
| JP2004529102A (ja) * | 2000-10-24 | 2004-09-24 | イミュネックス・コーポレーション | 併用療法を用いて、腫瘍を治療する方法 |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| JP4493882B2 (ja) * | 2001-06-19 | 2010-06-30 | 株式会社カネカ | 抗原およびこの抗原を識別するモノクローナル抗体 |
-
2004
- 2004-07-29 EP EP04017907A patent/EP1621550A1/en not_active Withdrawn
-
2005
- 2005-07-21 JP JP2007522989A patent/JP5042826B2/ja not_active Expired - Fee Related
- 2005-07-21 CN CN2005800324298A patent/CN101076540B/zh not_active Expired - Fee Related
- 2005-07-21 DE DE602005019050T patent/DE602005019050D1/de not_active Expired - Lifetime
- 2005-07-21 AT AT05764208T patent/ATE455847T1/de active
- 2005-07-21 WO PCT/EP2005/007957 patent/WO2006010558A1/en not_active Ceased
- 2005-07-21 RU RU2007107369/13A patent/RU2390558C2/ru not_active IP Right Cessation
- 2005-07-21 BR BRPI0513855-8A patent/BRPI0513855A/pt not_active IP Right Cessation
- 2005-07-21 US US11/631,262 patent/US20070264231A1/en not_active Abandoned
- 2005-07-21 HR HR20100227T patent/HRP20100227T1/hr unknown
- 2005-07-21 PT PT05764208T patent/PT1771468E/pt unknown
- 2005-07-21 PL PL05764208T patent/PL1771468T3/pl unknown
- 2005-07-21 EP EP05764208A patent/EP1771468B1/en not_active Expired - Lifetime
- 2005-07-21 SI SI200530969T patent/SI1771468T1/sl unknown
- 2005-07-21 MX MX2007001152A patent/MX2007001152A/es active IP Right Grant
- 2005-07-21 AU AU2005266543A patent/AU2005266543B2/en not_active Ceased
- 2005-07-21 RS RSP-2010/0179A patent/RS51381B/sr unknown
- 2005-07-21 NZ NZ552223A patent/NZ552223A/en not_active IP Right Cessation
- 2005-07-21 CA CA002571426A patent/CA2571426A1/en not_active Abandoned
- 2005-07-21 ES ES05764208T patent/ES2340400T3/es not_active Expired - Lifetime
- 2005-07-21 ZA ZA200701231A patent/ZA200701231B/xx unknown
- 2005-07-21 DK DK05764208.4T patent/DK1771468T3/da active
- 2005-07-21 KR KR1020077000005A patent/KR20070047757A/ko not_active Ceased
-
2006
- 2006-12-21 IL IL180233A patent/IL180233A/en not_active IP Right Cessation
-
2007
- 2007-02-20 NO NO20070956A patent/NO20070956L/no not_active Application Discontinuation
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