HRP20090490T1 - Processes for preparing eptifibatide and pertinent intermediate compounds - Google Patents
Processes for preparing eptifibatide and pertinent intermediate compoundsInfo
- Publication number
- HRP20090490T1 HRP20090490T1 HR20090490T HRP20090490T HRP20090490T1 HR P20090490 T1 HRP20090490 T1 HR P20090490T1 HR 20090490 T HR20090490 T HR 20090490T HR P20090490 T HRP20090490 T HR P20090490T HR P20090490 T1 HRP20090490 T1 HR P20090490T1
- Authority
- HR
- Croatia
- Prior art keywords
- eptifibatide
- processes
- fragment
- intermediate compounds
- preparing
- Prior art date
Links
- GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 title abstract 8
- 108010056764 Eptifibatide Proteins 0.000 title abstract 5
- 229960004468 eptifibatide Drugs 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- YEDNBEGNKOANMB-REOHCLBHSA-N (2r)-2-amino-3-sulfanylpropanamide Chemical group SC[C@H](N)C(N)=O YEDNBEGNKOANMB-REOHCLBHSA-N 0.000 abstract 1
- PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical group CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006664 bond formation reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Combined Means For Separation Of Solids (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56045304P | 2004-04-08 | 2004-04-08 | |
| PCT/US2005/011873 WO2005100381A2 (en) | 2004-04-08 | 2005-04-08 | Processes for preparing eptifibatide and pertinent intermediate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090490T1 true HRP20090490T1 (en) | 2009-10-31 |
Family
ID=34956145
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090490T HRP20090490T1 (en) | 2004-04-08 | 2009-09-15 | Processes for preparing eptifibatide and pertinent intermediate compounds |
| HR20110812T HRP20110812T1 (en) | 2004-04-08 | 2011-11-02 | Processes for preparing eptifibatide and pertinent intermediate compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110812T HRP20110812T1 (en) | 2004-04-08 | 2011-11-02 | Processes for preparing eptifibatide and pertinent intermediate compounds |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7674768B2 (es) |
| EP (2) | EP2204383B1 (es) |
| JP (2) | JP4926942B2 (es) |
| KR (1) | KR101238133B1 (es) |
| CN (1) | CN1972960B (es) |
| AT (2) | ATE519781T1 (es) |
| AU (1) | AU2005233603B2 (es) |
| CA (1) | CA2562157C (es) |
| CY (2) | CY1109357T1 (es) |
| DE (1) | DE602005014956D1 (es) |
| DK (2) | DK1735345T3 (es) |
| ES (2) | ES2328713T3 (es) |
| HK (2) | HK1099313A1 (es) |
| HR (2) | HRP20090490T1 (es) |
| ME (2) | ME01063B (es) |
| MX (1) | MXPA06011904A (es) |
| PL (2) | PL1735345T3 (es) |
| PT (2) | PT1735345E (es) |
| RS (2) | RS51182B (es) |
| SI (2) | SI2204383T1 (es) |
| WO (1) | WO2005100381A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1709065T3 (da) * | 2004-10-04 | 2010-08-23 | Novetide Ltd | Modion-bytningsfremgangsmåde til peptider |
| NL2000126C2 (nl) * | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
| KR101257330B1 (ko) * | 2008-02-06 | 2013-04-23 | 바이오콘 리미티드 | 펩타이드 정제 방법 |
| WO2009150657A1 (en) * | 2008-06-09 | 2009-12-17 | Natco Pharma Limited | Improved process for preparation of eptifibatide by fmoc solid phase synthesis |
| CN101538314B (zh) * | 2009-01-13 | 2012-10-03 | 深圳翰宇药业股份有限公司 | 一种纯化爱啡肽的方法 |
| CN101747412A (zh) * | 2009-12-30 | 2010-06-23 | 江苏诺泰制药技术有限公司 | 一种依替非巴肽的合成制备工艺 |
| CN102174081B (zh) * | 2011-03-09 | 2013-05-29 | 杭州华津允上医药有限公司 | 埃替非巴肽及其前体的制备方法 |
| CN102827249A (zh) * | 2011-06-14 | 2012-12-19 | 江苏豪森医药集团连云港宏创医药有限公司 | 一种依替巴肽的液相合成方法 |
| CN103408637B (zh) | 2013-06-27 | 2015-12-02 | 深圳翰宇药业股份有限公司 | 一种爱啡肽的制备方法 |
| CN104710509B (zh) * | 2013-12-11 | 2018-01-02 | 深圳翰宇药业股份有限公司 | 一种爱啡肽的制备方法 |
| CN108250265A (zh) * | 2016-12-29 | 2018-07-06 | 北京中科亚光生物科技有限公司 | 一种合成含有分子内二硫键的多肽的新工艺 |
| CN110894212B (zh) * | 2018-08-24 | 2021-06-04 | 翰宇药业（武汉）有限公司 | 一种合成依替巴肽硫醚的方法 |
| CN109251234A (zh) * | 2018-10-08 | 2019-01-22 | 重庆科脉生物化工有限公司 | 一种抗血小板聚集药物爱啡肽的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2616785B1 (fr) * | 1987-06-19 | 1989-10-06 | Solvay | Composes guanidiniques comprenant un ion tetraphenylborate substitue et procede d'obtention de ces composes et utilisation des composes lors de la synthese peptidique |
| US5686568A (en) * | 1989-06-16 | 1997-11-11 | Cor Therapeutics, Inc. | Platelet aggregration inhibitors |
| US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
| BE1007184A3 (fr) * | 1993-06-18 | 1995-04-18 | Solvay | Procede de preparation d'un amide d'alpha-aminoacide, utilisable en synthese peptidique. |
| US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
| WO2003093302A2 (en) * | 2002-05-03 | 2003-11-13 | Avecia Limited | Process for the synthesis of peptides amides by side-chain attachement to a solid phase |
| DE04759123T1 (de) * | 2003-04-07 | 2005-08-18 | Novetide Ltd. | Verfahren zur herstellung cyclischer peptide |
| NL2000126C2 (nl) | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
-
2005
- 2005-04-08 CN CN2005800107525A patent/CN1972960B/zh not_active Expired - Fee Related
- 2005-04-08 AT AT09075233T patent/ATE519781T1/de active
- 2005-04-08 SI SI200531388T patent/SI2204383T1/sl unknown
- 2005-04-08 ES ES05735068T patent/ES2328713T3/es active Active
- 2005-04-08 SI SI200530776T patent/SI1735345T1/sl unknown
- 2005-04-08 DE DE602005014956T patent/DE602005014956D1/de active Active
- 2005-04-08 DK DK05735068T patent/DK1735345T3/da active
- 2005-04-08 KR KR1020067020842A patent/KR101238133B1/ko not_active IP Right Cessation
- 2005-04-08 DK DK09075233.8T patent/DK2204383T3/da active
- 2005-04-08 PL PL05735068T patent/PL1735345T3/pl unknown
- 2005-04-08 EP EP09075233A patent/EP2204383B1/en active Active
- 2005-04-08 ES ES09075233T patent/ES2369872T3/es active Active
- 2005-04-08 EP EP05735068A patent/EP1735345B1/en active Active
- 2005-04-08 US US11/101,983 patent/US7674768B2/en not_active Expired - Fee Related
- 2005-04-08 MX MXPA06011904A patent/MXPA06011904A/es active IP Right Grant
- 2005-04-08 WO PCT/US2005/011873 patent/WO2005100381A2/en active Application Filing
- 2005-04-08 ME MEP-2009-347A patent/ME01063B/me unknown
- 2005-04-08 PT PT05735068T patent/PT1735345E/pt unknown
- 2005-04-08 PL PL09075233T patent/PL2204383T3/pl unknown
- 2005-04-08 ME MEP-2011-175A patent/ME01260B/me unknown
- 2005-04-08 PT PT09075233T patent/PT2204383E/pt unknown
- 2005-04-08 RS RSP-2009/0399A patent/RS51182B/sr unknown
- 2005-04-08 RS RS20110463A patent/RS51929B/en unknown
- 2005-04-08 AT AT05735068T patent/ATE433997T1/de active
- 2005-04-08 CA CA2562157A patent/CA2562157C/en not_active Expired - Fee Related
- 2005-04-08 JP JP2007507520A patent/JP4926942B2/ja not_active Expired - Fee Related
- 2005-04-08 AU AU2005233603A patent/AU2005233603B2/en not_active Ceased
-
2007
- 2007-05-22 HK HK07105387.3A patent/HK1099313A1/xx not_active IP Right Cessation
-
2009
- 2009-09-07 CY CY20091100931T patent/CY1109357T1/el unknown
- 2009-09-15 HR HR20090490T patent/HRP20090490T1/xx unknown
- 2009-10-23 US US12/604,600 patent/US20100105609A1/en not_active Abandoned
-
2010
- 2010-12-30 HK HK10112216.1A patent/HK1145691A1/xx not_active IP Right Cessation
-
2011
- 2011-10-31 CY CY20111101038T patent/CY1111904T1/el unknown
- 2011-11-02 HR HR20110812T patent/HRP20110812T1/xx unknown
- 2011-12-06 JP JP2011266478A patent/JP2012111756A/ja active Pending
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