HRP20090474T1 - Process and intermediates for the synthesis of caspofungin - Google Patents
Process and intermediates for the synthesis of caspofunginInfo
- Publication number
- HRP20090474T1 HRP20090474T1 HR20090474T HRP20090474T HRP20090474T1 HR P20090474 T1 HRP20090474 T1 HR P20090474T1 HR 20090474 T HR20090474 T HR 20090474T HR P20090474 T HRP20090474 T HR P20090474T HR P20090474 T1 HRP20090474 T1 HR P20090474T1
- Authority
- HR
- Croatia
- Prior art keywords
- intermediates
- caspofungin
- synthesis
- processes
- preparing
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 108010020326 Caspofungin Proteins 0.000 title abstract 2
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 title abstract 2
- 229960003034 caspofungin Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- -1 caspofungin Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05024961A EP1785432A1 (en) | 2005-11-15 | 2005-11-15 | Process and intermediates for the synthesis of caspofungin. |
| PCT/EP2006/010867 WO2007057141A1 (en) | 2005-11-15 | 2006-11-13 | Process and intermediates for the synthesis of caspofungin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090474T1 true HRP20090474T1 (en) | 2009-10-31 |
Family
ID=36001076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090474T HRP20090474T1 (en) | 2005-11-15 | 2009-09-07 | Process and intermediates for the synthesis of caspofungin |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080319162A1 (zh) |
| EP (2) | EP1785432A1 (zh) |
| JP (1) | JP4966314B2 (zh) |
| KR (1) | KR101342304B1 (zh) |
| CN (1) | CN101305018B (zh) |
| AT (1) | ATE435233T1 (zh) |
| BR (1) | BRPI0618591A2 (zh) |
| CA (1) | CA2626921C (zh) |
| DE (1) | DE602006007612D1 (zh) |
| DK (1) | DK1951747T3 (zh) |
| ES (1) | ES2327962T3 (zh) |
| HR (1) | HRP20090474T1 (zh) |
| IL (1) | IL190333A (zh) |
| PL (1) | PL1951747T3 (zh) |
| PT (1) | PT1951747E (zh) |
| SI (1) | SI1951747T1 (zh) |
| WO (1) | WO2007057141A1 (zh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0715113A2 (pt) | 2006-07-26 | 2013-06-04 | Sandoz Ag Sandoz Sa Sandoz Ltd | formulaÇço de caspofungina |
| US20090291996A1 (en) * | 2008-05-21 | 2009-11-26 | Ferenc Korodi | Caspofungin free of caspofungin Co |
| US8048853B2 (en) | 2008-06-13 | 2011-11-01 | Xellia Pharmaceuticals Aps | Process for preparing pharmaceutical compound and intermediates thereof |
| EP2183271A1 (en) * | 2008-06-25 | 2010-05-12 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Caspofungin free of caspofungin impurity a |
| US20100256074A1 (en) * | 2008-06-25 | 2010-10-07 | Chaim Eidelman | Processes for preparing high purity aza cyclohexapeptides |
| TW201024322A (en) * | 2008-12-31 | 2010-07-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate |
| WO2010108637A1 (en) | 2009-03-27 | 2010-09-30 | Axellia Pharmaceuticals Aps | Crystalline compound |
| EP2463293A4 (en) * | 2009-08-06 | 2013-06-05 | Shanghai Techwell Biopharm Co | AZACYCLOHEXAPEPTIDE BZW. ITS PHARMACEUTICAL ACCEPTABLE SALT, MANUFACTURING PROCESS AND USE |
| EP2621941A1 (en) * | 2010-09-28 | 2013-08-07 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Method for isolating a cyclohexapeptide |
| CN102367267B (zh) | 2010-11-10 | 2013-09-04 | 上海天伟生物制药有限公司 | 一种卡泊芬净的制备方法 |
| CN102367269B (zh) | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其制备方法和用途 |
| CN102367268B (zh) | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其用途 |
| KR101331984B1 (ko) | 2010-12-09 | 2013-11-25 | 종근당바이오 주식회사 | 카스포펀진 제조방법 및 그의 신규 중간체 |
| CN102219833A (zh) * | 2011-04-18 | 2011-10-19 | 深圳市健元医药科技有限公司 | 一种更加安全的棘白菌类抗真菌药的制备方法 |
| CN102746384B (zh) | 2011-04-22 | 2016-01-20 | 上海天伟生物制药有限公司 | 一种高纯度的卡泊芬净或其盐及其制备方法和用途 |
| CN103003295B (zh) | 2011-04-28 | 2014-09-17 | 上海源力生物技术有限公司 | 用于合成卡帕芬净的中间体及其制备方法 |
| CN106478781B (zh) * | 2015-09-02 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 卡泊芬净的制备方法 |
| CN105440109B (zh) * | 2015-11-26 | 2019-03-05 | 成都摩尔生物医药有限公司 | 一种卡泊芬净的制备方法 |
| CN109721641B (zh) * | 2017-10-31 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种卡泊芬净的合成方法 |
| EP3620462A1 (en) * | 2018-09-04 | 2020-03-11 | Xellia Pharmaceuticals ApS | Process for the preparation of caspofungin |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194377A (en) | 1989-06-30 | 1993-03-16 | Merck & Co., Inc. | Antibiotic agent |
| US5202309A (en) | 1989-06-30 | 1993-04-13 | Merck & Co., Inc. | Antibiotic cyclopeptide fermentation product |
| US6030944A (en) * | 1991-10-01 | 2000-02-29 | Merck & Co., Inc. | Cyclohexapeptidyl bisamine compounds |
| WO1994009033A1 (en) * | 1992-10-16 | 1994-04-28 | Merck & Co., Inc. | An improved process for cyclohexapeptidyl bisamine compounds |
| US5378804A (en) * | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| DK0779895T3 (da) * | 1994-08-23 | 2000-03-13 | Merck & Co Inc | Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider |
| US5552521A (en) | 1995-02-10 | 1996-09-03 | Merck & Co., Inc. | Process for preparing certain aza cyclohexapeptides |
| HRP970318B1 (en) | 1996-06-14 | 2002-06-30 | Merck & Co Inc | A process for preparing certain aza cyclohexapeptides |
| US5936062A (en) | 1997-06-12 | 1999-08-10 | Merck & Co., Inc. | Process for preparing certain aza cyclohexapeptides |
| US5965612A (en) * | 1997-08-22 | 1999-10-12 | Merck & Co., Inc. | 4-cyano-4-deformylsordaricin derivatives |
| US5972996A (en) * | 1997-08-22 | 1999-10-26 | Merck & Co., Inc. | 4-cyano-4-deformylsordarin derivatives |
| JP2004521102A (ja) * | 2001-01-09 | 2004-07-15 | メルク エンド カムパニー インコーポレーテッド | 抗真菌化合物の活性代謝物 |
| AR035808A1 (es) | 2001-04-12 | 2004-07-14 | Merck & Co Inc | Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas |
-
2005
- 2005-11-15 EP EP05024961A patent/EP1785432A1/en not_active Withdrawn
-
2006
- 2006-11-13 SI SI200630411T patent/SI1951747T1/sl unknown
- 2006-11-13 CA CA2626921A patent/CA2626921C/en not_active Expired - Fee Related
- 2006-11-13 PL PL06818498T patent/PL1951747T3/pl unknown
- 2006-11-13 ES ES06818498T patent/ES2327962T3/es active Active
- 2006-11-13 EP EP06818498A patent/EP1951747B1/en active Active
- 2006-11-13 DK DK06818498T patent/DK1951747T3/da active
- 2006-11-13 JP JP2008540498A patent/JP4966314B2/ja not_active Expired - Fee Related
- 2006-11-13 US US12/093,657 patent/US20080319162A1/en not_active Abandoned
- 2006-11-13 BR BRPI0618591-6A patent/BRPI0618591A2/pt not_active IP Right Cessation
- 2006-11-13 PT PT06818498T patent/PT1951747E/pt unknown
- 2006-11-13 DE DE602006007612T patent/DE602006007612D1/de active Active
- 2006-11-13 AT AT06818498T patent/ATE435233T1/de active
- 2006-11-13 CN CN2006800422331A patent/CN101305018B/zh not_active Expired - Fee Related
- 2006-11-13 WO PCT/EP2006/010867 patent/WO2007057141A1/en active Application Filing
-
2008
- 2008-03-20 IL IL190333A patent/IL190333A/en not_active IP Right Cessation
- 2008-05-14 KR KR1020087011523A patent/KR101342304B1/ko not_active IP Right Cessation
-
2009
- 2009-09-07 HR HR20090474T patent/HRP20090474T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101305018B (zh) | 2013-03-27 |
| JP2009515917A (ja) | 2009-04-16 |
| KR20080069998A (ko) | 2008-07-29 |
| DE602006007612D1 (de) | 2009-08-13 |
| JP4966314B2 (ja) | 2012-07-04 |
| PL1951747T3 (pl) | 2009-12-31 |
| EP1785432A1 (en) | 2007-05-16 |
| ES2327962T3 (es) | 2009-11-05 |
| KR101342304B1 (ko) | 2013-12-16 |
| EP1951747A1 (en) | 2008-08-06 |
| ATE435233T1 (de) | 2009-07-15 |
| US20080319162A1 (en) | 2008-12-25 |
| SI1951747T1 (sl) | 2009-12-31 |
| CA2626921C (en) | 2013-09-17 |
| CN101305018A (zh) | 2008-11-12 |
| CA2626921A1 (en) | 2007-05-24 |
| WO2007057141A1 (en) | 2007-05-24 |
| EP1951747B1 (en) | 2009-07-01 |
| IL190333A (en) | 2010-12-30 |
| BRPI0618591A2 (pt) | 2011-09-06 |
| PT1951747E (pt) | 2009-08-12 |
| DK1951747T3 (da) | 2009-10-12 |
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