HRP20090421T1 - Postupak za pripremu halogenoalkilnitrata - Google Patents
Postupak za pripremu halogenoalkilnitrata Download PDFInfo
- Publication number
- HRP20090421T1 HRP20090421T1 HR20090421T HRP20090421T HRP20090421T1 HR P20090421 T1 HRP20090421 T1 HR P20090421T1 HR 20090421 T HR20090421 T HR 20090421T HR P20090421 T HRP20090421 T HR P20090421T HR P20090421 T1 HRP20090421 T1 HR P20090421T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- ch2cl2
- group
- perfluoroheptane
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract 12
- 150000001875 compounds Chemical class 0.000 claims abstract 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract 8
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims abstract 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910017604 nitric acid Inorganic materials 0.000 claims abstract 4
- 229960004624 perflexane Drugs 0.000 claims abstract 4
- LGUZHRODIJCVOC-UHFFFAOYSA-N perfluoroheptane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F LGUZHRODIJCVOC-UHFFFAOYSA-N 0.000 claims abstract 4
- ZJIJAJXFLBMLCK-UHFFFAOYSA-N perfluorohexane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F ZJIJAJXFLBMLCK-UHFFFAOYSA-N 0.000 claims abstract 4
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims abstract 4
- 239000003960 organic solvent Substances 0.000 claims abstract 3
- 239000002904 solvent Substances 0.000 claims abstract 3
- 229910004069 NO2BF4 Inorganic materials 0.000 claims abstract 2
- 229910004679 ONO2 Inorganic materials 0.000 claims abstract 2
- 229910052794 bromium Inorganic materials 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 2
- OMBRFUXPXNIUCZ-UHFFFAOYSA-N dioxidonitrogen(1+) Chemical class O=[N+]=O OMBRFUXPXNIUCZ-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 230000000802 nitrating effect Effects 0.000 claims abstract 2
- 235000010288 sodium nitrite Nutrition 0.000 claims abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract 2
- -1 NO2BF4 Chemical class 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Otopina koja sadrži: a) spoj opće formule (I) X-(CH2)n-ONO2 (I) gdjeX je a halogen atom odabran između Cl i Br; n je cijeli broj od 3 do 6; i b) otapalo odabrano iz skupine sastavljene od CH2Cl2, CHCl3, CCl4, perfluorheksana, perfluorheptana; naznačena time da je spoj formule (I) prisutan u koncentraciji ne većoj od 20% masenih. Patent sadrži još 7 patentnih zahtjeva.
Claims (8)
1. Otopina koja sadrži:
a) spoj opće formule (I)
X-(CH2)n-ONO2 (I)
gdje
X je a halogen atom odabran između Cl i Br;
n je cijeli broj od 3 do 6; i
b) otapalo odabrano iz skupine sastavljene od CH2Cl2, CHCl3, CCl4, perfluorheksana, perfluorheptana;
naznačena time da je spoj formule (I) prisutan u koncentraciji ne većoj od 20% masenih.
2. Otopina prema zahtjevu 1 koja sadrži spoj formule (I), naznačena time da n je 4.
3. Otopina prema zahtjevu 1 ili 2 koja sadrži spoj formule (I), naznačena time da X je Br.
4. Otopina prema bilo kojem zahtjevu 1 do 3, naznačena time da je otapalo CH2Cl2.
5. Otopina prema bilo kojem zahtjevu 1 do 4, naznačena time da je spoj formule (I) prisutan u koncentraciji od 10 do 20% masenih.
6. Postupak za pripremu spoja formule (I) kako je definirano u zahtjevu 1, naznačen time da navedeni postupak sadrži dodavanje spoja formule (II)
X-(CH2)n -OH (II)
u kojoj su X i n definirani u zahtjevu 1
u nitratni agens koji je odabran iz skupine koja je sastavljena od koncentrirane dušične kiseline/koncentrirane sulfatne kiseline (sulfonitratna smjesa), same dušične kiseline, NaNO2 u trifluoroctenoj kiselini, nitronijeve soli kao što je NO2BF4 i organskog otapala odabranog iz skupine koja je sastavljena od CH2Cl2, CHCl3, CCl4, perfluorheksana, perfluorheptana.
7. Postupak prema zahtjevu 6 za pripremu spoja formule (I), naznačen time da X je Br.
8. Postupak prema zahtjevu 6 ili 7, naznačen time da je organsko otapalo CH2Cl2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04292785 | 2004-11-25 | ||
| PCT/EP2005/055865 WO2006056535A1 (en) | 2004-11-25 | 2005-11-09 | Process for preparing halogenoalkylnitrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090421T1 true HRP20090421T1 (hr) | 2009-09-30 |
Family
ID=35517672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090421T HRP20090421T1 (hr) | 2004-11-25 | 2009-07-30 | Postupak za pripremu halogenoalkilnitrata |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7745496B2 (hr) |
| EP (1) | EP1814840B1 (hr) |
| JP (1) | JP2008521770A (hr) |
| KR (1) | KR20070083822A (hr) |
| CN (1) | CN101065348B (hr) |
| AT (1) | ATE434599T1 (hr) |
| AU (1) | AU2005308881B2 (hr) |
| BR (1) | BRPI0517897A (hr) |
| CA (1) | CA2589184A1 (hr) |
| CY (1) | CY1110493T1 (hr) |
| DE (1) | DE602005015134D1 (hr) |
| DK (1) | DK1814840T3 (hr) |
| ES (1) | ES2327550T3 (hr) |
| HR (1) | HRP20090421T1 (hr) |
| IL (1) | IL182900A0 (hr) |
| MX (1) | MX2007006235A (hr) |
| NO (1) | NO20073227L (hr) |
| NZ (1) | NZ554975A (hr) |
| PL (1) | PL1814840T3 (hr) |
| PT (1) | PT1814840E (hr) |
| RS (1) | RS51188B (hr) |
| RU (1) | RU2388746C2 (hr) |
| SI (1) | SI1814840T1 (hr) |
| WO (1) | WO2006056535A1 (hr) |
| ZA (1) | ZA200703887B (hr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101885684B (zh) * | 2010-07-01 | 2013-10-30 | 南京中医药大学 | 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用 |
| US20160207764A1 (en) * | 2015-01-21 | 2016-07-21 | Demetrios Markou | Novel Methods for Storing Hydrogen in PFC Solutions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2142016B (en) * | 1983-06-24 | 1986-07-23 | Aeci Ltd | Preparing nitric acid esters of organic hydroxy compounds |
| US5089652A (en) | 1990-01-17 | 1992-02-18 | Atlas Powder Company | Nitrate ester preparation |
| ITMI20021861A1 (it) | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| ITMI20022410A1 (it) * | 2002-11-14 | 2004-05-15 | Dinamite Dipharma S P A | Procedimento per la nitrazione di alcandioli. |
| ITMI20022409A1 (it) | 2002-11-14 | 2004-05-15 | Dinamite Dipharma S P A | Procedimento per la purificazione di 1, 4-butandiolo mononitrato. |
| US20050192346A1 (en) * | 2004-03-01 | 2005-09-01 | Yao-Jun Shi | Process for making nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors |
-
2005
- 2005-11-09 BR BRPI0517897-5A patent/BRPI0517897A/pt not_active IP Right Cessation
- 2005-11-09 RU RU2007118914/04A patent/RU2388746C2/ru not_active IP Right Cessation
- 2005-11-09 EP EP05816096A patent/EP1814840B1/en active Active
- 2005-11-09 CA CA002589184A patent/CA2589184A1/en not_active Abandoned
- 2005-11-09 ES ES05816096T patent/ES2327550T3/es active Active
- 2005-11-09 DK DK05816096T patent/DK1814840T3/da active
- 2005-11-09 PT PT05816096T patent/PT1814840E/pt unknown
- 2005-11-09 MX MX2007006235A patent/MX2007006235A/es active IP Right Grant
- 2005-11-09 DE DE602005015134T patent/DE602005015134D1/de active Active
- 2005-11-09 AU AU2005308881A patent/AU2005308881B2/en not_active Ceased
- 2005-11-09 JP JP2007541926A patent/JP2008521770A/ja active Pending
- 2005-11-09 SI SI200530763T patent/SI1814840T1/sl unknown
- 2005-11-09 PL PL05816096T patent/PL1814840T3/pl unknown
- 2005-11-09 AT AT05816096T patent/ATE434599T1/de active
- 2005-11-09 CN CN2005800404292A patent/CN101065348B/zh not_active Expired - Fee Related
- 2005-11-09 KR KR1020077009528A patent/KR20070083822A/ko not_active Application Discontinuation
- 2005-11-09 RS RSP-2009/0390A patent/RS51188B/sr unknown
- 2005-11-09 NZ NZ554975A patent/NZ554975A/en not_active IP Right Cessation
- 2005-11-09 US US11/667,970 patent/US7745496B2/en not_active Expired - Fee Related
- 2005-11-09 WO PCT/EP2005/055865 patent/WO2006056535A1/en active Application Filing
-
2007
- 2007-05-01 IL IL182900A patent/IL182900A0/en unknown
- 2007-05-14 ZA ZA200703887A patent/ZA200703887B/xx unknown
- 2007-06-22 NO NO20073227A patent/NO20073227L/no not_active Application Discontinuation
-
2009
- 2009-07-30 HR HR20090421T patent/HRP20090421T1/hr unknown
- 2009-09-10 CY CY20091100943T patent/CY1110493T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE434599T1 (de) | 2009-07-15 |
| AU2005308881B2 (en) | 2010-10-28 |
| SI1814840T1 (sl) | 2009-10-31 |
| EP1814840B1 (en) | 2009-06-24 |
| NZ554975A (en) | 2011-03-31 |
| AU2005308881A1 (en) | 2006-06-01 |
| PT1814840E (pt) | 2009-08-10 |
| CA2589184A1 (en) | 2006-06-01 |
| ZA200703887B (en) | 2009-03-25 |
| RS51188B (sr) | 2010-10-31 |
| US7745496B2 (en) | 2010-06-29 |
| PL1814840T3 (pl) | 2010-05-31 |
| CN101065348A (zh) | 2007-10-31 |
| RU2007118914A (ru) | 2008-12-27 |
| JP2008521770A (ja) | 2008-06-26 |
| CY1110493T1 (el) | 2015-04-29 |
| NO20073227L (no) | 2007-06-22 |
| ES2327550T3 (es) | 2009-10-30 |
| KR20070083822A (ko) | 2007-08-24 |
| BRPI0517897A (pt) | 2008-10-21 |
| WO2006056535A1 (en) | 2006-06-01 |
| RU2388746C2 (ru) | 2010-05-10 |
| DK1814840T3 (da) | 2009-10-12 |
| DE602005015134D1 (de) | 2009-08-06 |
| CN101065348B (zh) | 2012-10-03 |
| EP1814840A1 (en) | 2007-08-08 |
| IL182900A0 (en) | 2007-08-19 |
| US20080004463A1 (en) | 2008-01-03 |
| MX2007006235A (es) | 2007-07-20 |
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