HRP20090192B1 - Postupak za pripravu pleuromutilina - Google Patents

Postupak za pripravu pleuromutilina

Info

Publication number
HRP20090192B1
HRP20090192B1 HRP20090192AA HRP20090192A HRP20090192B1 HR P20090192 B1 HRP20090192 B1 HR P20090192B1 HR P20090192A A HRP20090192A A HR P20090192AA HR P20090192 A HRP20090192 A HR P20090192A HR P20090192 B1 HRP20090192 B1 HR P20090192B1
Authority
HR
Croatia
Prior art keywords
preparation
sulfanyl
butyryl
acetyl
amino
Prior art date
Application number
HRP20090192AA
Other languages
English (en)
Inventor
Ingolf Macher
Andreas Berger
Martin Decristoforo
Original Assignee
Nabriva Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabriva Therapeutics Ag filed Critical Nabriva Therapeutics Ag
Publication of HRP20090192A2 publication Critical patent/HRP20090192A2/hr
Publication of HRP20090192B1 publication Critical patent/HRP20090192B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Opisan je postupak za pripravu 14-O-[(N-(3-metil-2-amino-butiril-piperidinil)sulfanil)acetil]mutilina formule (I) pogodan je za proizvodnju u velikom mjerilu visoke čistoće proizvoda, i pri čemu ugljikov atom na piperidinskom prstenu povezan na sumporni atom je u (S)-konfiguraciji ili u (R)-konfiguraciji i novi kristaliničan oblik 14-O-[(N-3-metil-2-(R)-amino-butiril-piperidin-3(S)-il)sulfanil)acetil]mutilin-hidroklorida.
HRP20090192AA 2006-10-05 2009-04-01 Postupak za pripravu pleuromutilina HRP20090192B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06121852A EP1908750A1 (en) 2006-10-05 2006-10-05 Process for the preparation of pleuromutilins
PCT/AT2007/000468 WO2008040043A1 (en) 2006-10-05 2007-10-03 Process for the preparation of pleuromutilins

Publications (2)

Publication Number Publication Date
HRP20090192A2 HRP20090192A2 (hr) 2009-08-31
HRP20090192B1 true HRP20090192B1 (hr) 2016-05-06

Family

ID=37781773

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20090192AA HRP20090192B1 (hr) 2006-10-05 2009-04-01 Postupak za pripravu pleuromutilina

Country Status (22)

Country Link
US (2) US8334389B2 (hr)
EP (3) EP1908750A1 (hr)
JP (1) JP5557530B2 (hr)
KR (1) KR101577675B1 (hr)
CN (1) CN101595090B (hr)
AT (1) ATE523490T1 (hr)
AU (1) AU2007304867B2 (hr)
BR (1) BRPI0719205B8 (hr)
CA (1) CA2665347C (hr)
ES (1) ES2373341T3 (hr)
HK (1) HK1139135A1 (hr)
HR (1) HRP20090192B1 (hr)
IL (1) IL197970A (hr)
MX (1) MX2009003681A (hr)
MY (1) MY146357A (hr)
NO (1) NO341868B1 (hr)
NZ (1) NZ576034A (hr)
RU (1) RU2512591C2 (hr)
TW (1) TWI432416B (hr)
UA (1) UA96775C2 (hr)
WO (1) WO2008040043A1 (hr)
ZA (1) ZA200902159B (hr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
EP2399904A1 (en) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
CN104803911B (zh) * 2014-01-23 2018-01-05 中国科学院上海药物研究所 一类截短侧耳素化合物、其药物组合物、合成方法与用途
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421364A2 (en) * 1989-10-03 1991-04-10 Biochemie Gesellschaft M.B.H. Pleuromutilins
WO2002022580A1 (en) * 2000-09-13 2002-03-21 Biochemie Gesellschaft M.B.H. Antibacterials mutilins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3405632A1 (de) * 1984-02-17 1985-08-22 Sandoz-Patent-GmbH, 7850 Lörrach Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
ES2295657T3 (es) * 2002-07-24 2008-04-16 Nabriva Therapeutics Forschungs Gmbh Derivados de pleuromutilina como antimicrobianos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421364A2 (en) * 1989-10-03 1991-04-10 Biochemie Gesellschaft M.B.H. Pleuromutilins
WO2002022580A1 (en) * 2000-09-13 2002-03-21 Biochemie Gesellschaft M.B.H. Antibacterials mutilins

Also Published As

Publication number Publication date
EP2272829A3 (en) 2011-02-09
CN101595090B (zh) 2014-12-24
KR20090086203A (ko) 2009-08-11
NO341868B1 (no) 2018-02-12
WO2008040043A1 (en) 2008-04-10
BRPI0719205B1 (pt) 2020-04-28
TWI432416B (zh) 2014-04-01
JP2010505771A (ja) 2010-02-25
US20130053571A1 (en) 2013-02-28
UA96775C2 (en) 2011-12-12
BRPI0719205A2 (pt) 2014-02-04
NO20091261L (no) 2009-06-30
AU2007304867B2 (en) 2013-02-07
HK1139135A1 (en) 2010-09-10
TW200831461A (en) 2008-08-01
AU2007304867A1 (en) 2008-04-10
MY146357A (en) 2012-08-15
EP1908750A1 (en) 2008-04-09
NZ576034A (en) 2011-07-29
ZA200902159B (en) 2010-06-30
CN101595090A (zh) 2009-12-02
ATE523490T1 (de) 2011-09-15
IL197970A0 (en) 2009-12-24
EP2272829A2 (en) 2011-01-12
EP2069301B1 (en) 2011-09-07
US8334389B2 (en) 2012-12-18
JP5557530B2 (ja) 2014-07-23
CA2665347A1 (en) 2008-04-10
HRP20090192A2 (hr) 2009-08-31
US20090253748A1 (en) 2009-10-08
RU2512591C2 (ru) 2014-04-10
US8624033B2 (en) 2014-01-07
EP2069301A1 (en) 2009-06-17
CA2665347C (en) 2017-02-14
KR101577675B1 (ko) 2015-12-15
MX2009003681A (es) 2009-07-16
ES2373341T3 (es) 2012-02-02
RU2009116945A (ru) 2010-11-10
BRPI0719205B8 (pt) 2021-05-25
IL197970A (en) 2014-09-30

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