BRPI0719205B8 - pleuromutilinas, seus intermediários, seu sal de adição de ácido e seu processo para preparação, e composição farmacêutica - Google Patents
pleuromutilinas, seus intermediários, seu sal de adição de ácido e seu processo para preparação, e composição farmacêuticaInfo
- Publication number
- BRPI0719205B8 BRPI0719205B8 BRPI0719205A BRPI0719205A BRPI0719205B8 BR PI0719205 B8 BRPI0719205 B8 BR PI0719205B8 BR PI0719205 A BRPI0719205 A BR PI0719205A BR PI0719205 A BRPI0719205 A BR PI0719205A BR PI0719205 B8 BRPI0719205 B8 BR PI0719205B8
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- pleuromutilins
- intermediates
- pharmaceutical composition
- acid addition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- OBUUFWIMEGVAQS-UHFFFAOYSA-N Pleuromutenol Natural products CC1C(O)C(C)(C=C)CC(O)C2(C)C(C)CCC31C2C(=O)CC3 OBUUFWIMEGVAQS-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- STZYTFJPGGDRJD-NHUWBDDWSA-N retapamulin Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CS[C@@H]3C[C@H]4CC[C@H](N4C)C3)C)C[C@]32[C@H]1C(=O)CC3 STZYTFJPGGDRJD-NHUWBDDWSA-N 0.000 abstract 1
- 229960002771 retapamulin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
processo para a preparação de pleuromutilinas. a presente invenção refere-se a um processo para a preparação de [4-o-[(n-3-metil-2-(r)-amino- butiril-piperidinil)sulfanil)acetil]mutilinas de fórmula (i) exequível para a produção em grande escala de produtos de alta pureza, e em que o átomo de carbono no anel de peperidina acoplado ao átomo de enxofre está ou na configuração (s) ou na configuração (r)-, e uma nova forma cristalina de cloridrato de 14-o-[(n-3-metil-2-(r)-amino- butiril-piperidin-3(s)-ii)sulfanil)acetil]mutilinas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06121852.5 | 2006-10-05 | ||
| EP06121852A EP1908750A1 (en) | 2006-10-05 | 2006-10-05 | Process for the preparation of pleuromutilins |
| PCT/AT2007/000468 WO2008040043A1 (en) | 2006-10-05 | 2007-10-03 | Process for the preparation of pleuromutilins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0719205A2 BRPI0719205A2 (pt) | 2014-02-04 |
| BRPI0719205B1 BRPI0719205B1 (pt) | 2020-04-28 |
| BRPI0719205B8 true BRPI0719205B8 (pt) | 2021-05-25 |
Family
ID=37781773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0719205A BRPI0719205B8 (pt) | 2006-10-05 | 2007-10-03 | pleuromutilinas, seus intermediários, seu sal de adição de ácido e seu processo para preparação, e composição farmacêutica |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8334389B2 (pt) |
| EP (3) | EP1908750A1 (pt) |
| JP (1) | JP5557530B2 (pt) |
| KR (1) | KR101577675B1 (pt) |
| CN (1) | CN101595090B (pt) |
| AT (1) | ATE523490T1 (pt) |
| AU (1) | AU2007304867B2 (pt) |
| BR (1) | BRPI0719205B8 (pt) |
| CA (1) | CA2665347C (pt) |
| ES (1) | ES2373341T3 (pt) |
| HK (1) | HK1139135A1 (pt) |
| HR (1) | HRP20090192B1 (pt) |
| IL (1) | IL197970A (pt) |
| MX (1) | MX2009003681A (pt) |
| MY (1) | MY146357A (pt) |
| NO (1) | NO341868B1 (pt) |
| NZ (1) | NZ576034A (pt) |
| RU (1) | RU2512591C2 (pt) |
| TW (1) | TWI432416B (pt) |
| UA (1) | UA96775C2 (pt) |
| WO (1) | WO2008040043A1 (pt) |
| ZA (1) | ZA200902159B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
| EP2399904A1 (en) * | 2010-05-26 | 2011-12-28 | Nabriva Therapeutics AG | Process for the preparation of pleuromutilins |
| CN104803911B (zh) * | 2014-01-23 | 2018-01-05 | 中国科学院上海药物研究所 | 一类截短侧耳素化合物、其药物组合物、合成方法与用途 |
| TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3405632A1 (de) * | 1984-02-17 | 1985-08-22 | Sandoz-Patent-GmbH, 7850 Lörrach | Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung |
| HU208115B (en) * | 1989-10-03 | 1993-08-30 | Biochemie Gmbh | New process for producting pleuromutilin derivatives |
| GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
| PE20020676A1 (es) * | 2000-09-13 | 2002-08-27 | Biochemie Gmbh | Compuestos de mutilina como antibacterianos |
| RU2005105576A (ru) * | 2002-07-24 | 2005-10-10 | Сандоз АГ (CH) | Производные плевромутилина в качестве противомикроюных средств |
-
2006
- 2006-10-05 EP EP06121852A patent/EP1908750A1/en not_active Withdrawn
-
2007
- 2007-10-03 AT AT07815135T patent/ATE523490T1/de not_active IP Right Cessation
- 2007-10-03 US US12/444,330 patent/US8334389B2/en active Active
- 2007-10-03 EP EP10009550A patent/EP2272829A3/en not_active Withdrawn
- 2007-10-03 UA UAA200904312A patent/UA96775C2/ru unknown
- 2007-10-03 BR BRPI0719205A patent/BRPI0719205B8/pt not_active IP Right Cessation
- 2007-10-03 CA CA2665347A patent/CA2665347C/en active Active
- 2007-10-03 AU AU2007304867A patent/AU2007304867B2/en not_active Ceased
- 2007-10-03 ZA ZA200902159A patent/ZA200902159B/xx unknown
- 2007-10-03 JP JP2009530732A patent/JP5557530B2/ja not_active Expired - Fee Related
- 2007-10-03 EP EP07815135A patent/EP2069301B1/en active Active
- 2007-10-03 CN CN200780045162.5A patent/CN101595090B/zh not_active Expired - Fee Related
- 2007-10-03 RU RU2009116945/04A patent/RU2512591C2/ru active
- 2007-10-03 MX MX2009003681A patent/MX2009003681A/es active IP Right Grant
- 2007-10-03 WO PCT/AT2007/000468 patent/WO2008040043A1/en active Application Filing
- 2007-10-03 NZ NZ576034A patent/NZ576034A/en not_active IP Right Cessation
- 2007-10-03 KR KR1020097008971A patent/KR101577675B1/ko active IP Right Grant
- 2007-10-03 ES ES07815135T patent/ES2373341T3/es active Active
- 2007-10-03 MY MYPI20091363A patent/MY146357A/en unknown
- 2007-10-03 TW TW096137112A patent/TWI432416B/zh not_active IP Right Cessation
-
2009
- 2009-03-26 NO NO20091261A patent/NO341868B1/no unknown
- 2009-04-01 HR HRP20090192AA patent/HRP20090192B1/hr not_active IP Right Cessation
- 2009-04-05 IL IL197970A patent/IL197970A/en active IP Right Grant
-
2010
- 2010-05-18 HK HK10104886.7A patent/HK1139135A1/xx not_active IP Right Cessation
-
2012
- 2012-10-26 US US13/662,063 patent/US8624033B2/en active Active
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Legal Events
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/04/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/10/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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