HRP20090101T3 - N-(1h-indolyl)-h-indole-2-carboxamide derivatives, their preparation and their therapeutic use - Google Patents

N-(1h-indolyl)-h-indole-2-carboxamide derivatives, their preparation and their therapeutic use

Info

Publication number
HRP20090101T3
HRP20090101T3 HR20090101T HRP20090101T HRP20090101T3 HR P20090101 T3 HRP20090101 T3 HR P20090101T3 HR 20090101 T HR20090101 T HR 20090101T HR P20090101 T HRP20090101 T HR P20090101T HR P20090101 T3 HRP20090101 T3 HR P20090101T3
Authority
HR
Croatia
Prior art keywords
alkyl
group
cycloalkyl
fluoroalkyl
aryl
Prior art date
Application number
HR20090101T
Other languages
English (en)
Croatian (hr)
Inventor
Dubois Laurent
Evanno Yannick
Even Luc
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20090101T3 publication Critical patent/HRP20090101T3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20090101T 2004-08-05 2009-02-17 N-(1h-indolyl)-h-indole-2-carboxamide derivatives, their preparation and their therapeutic use HRP20090101T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0408652A FR2874015B1 (fr) 2004-08-05 2004-08-05 Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
PCT/FR2005/002014 WO2006024776A1 (fr) 2004-08-05 2005-08-02 Derives de n-(1 h-indolyl)-i h-ind0le-2-carb0xamides, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HRP20090101T3 true HRP20090101T3 (en) 2009-03-31

Family

ID=34950701

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090101T HRP20090101T3 (en) 2004-08-05 2009-02-17 N-(1h-indolyl)-h-indole-2-carboxamide derivatives, their preparation and their therapeutic use

Country Status (38)

Country Link
US (3) US7384969B2 (xx)
EP (1) EP1776340B1 (xx)
JP (1) JP5100381B2 (xx)
KR (1) KR101215162B1 (xx)
CN (1) CN101010297B (xx)
AR (1) AR050283A1 (xx)
AT (1) ATE416160T1 (xx)
AU (1) AU2005279085B2 (xx)
BR (1) BRPI0513087A (xx)
CA (1) CA2576727C (xx)
CR (1) CR8889A (xx)
CY (1) CY1108816T1 (xx)
DE (1) DE602005011450D1 (xx)
DK (1) DK1776340T3 (xx)
EA (1) EA011714B1 (xx)
EC (1) ECSP077215A (xx)
ES (1) ES2318542T3 (xx)
FR (1) FR2874015B1 (xx)
HK (1) HK1110308A1 (xx)
HR (1) HRP20090101T3 (xx)
IL (1) IL180911A (xx)
MA (1) MA28845B1 (xx)
ME (1) ME01663B (xx)
MX (1) MX2007001436A (xx)
MY (1) MY139286A (xx)
NO (1) NO340060B1 (xx)
NZ (1) NZ552924A (xx)
PE (1) PE20060557A1 (xx)
PL (1) PL1776340T3 (xx)
PT (1) PT1776340E (xx)
RS (1) RS50853B (xx)
SI (1) SI1776340T1 (xx)
TN (1) TNSN07041A1 (xx)
TW (1) TWI360538B (xx)
UA (1) UA90483C2 (xx)
UY (1) UY29046A1 (xx)
WO (1) WO2006024776A1 (xx)
ZA (1) ZA200700999B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
FR2910473B1 (fr) 2006-12-26 2009-02-13 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
FR2911604B1 (fr) 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
NZ582056A (en) * 2007-08-10 2012-08-31 Lundbeck & Co As H Bicyclic heteroaryl compounds for treating conditions related to p2x7 receptor activation
CL2008003749A1 (es) 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
FR2926556B1 (fr) * 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926555B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
US20100210682A1 (en) * 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
FR3007850B1 (fr) 2013-06-28 2015-07-17 Probayes Systeme de prediction de temperature

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
IL125177A0 (en) * 1996-02-13 1999-03-12 Abbott Lab Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
CA2297894A1 (en) * 1997-08-04 1999-02-11 Abbott Laboratories Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
MXPA04005427A (es) * 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
MXPA04011472A (es) * 2002-05-22 2005-02-14 Amgen Inc Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor.
US20060183753A1 (en) * 2002-12-20 2006-08-17 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
JP4909068B2 (ja) 2003-02-14 2012-04-04 グラクソ グループ リミテッド カルボキサミド誘導体
US7544803B2 (en) * 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
EP1776340B1 (fr) 2008-12-03
JP5100381B2 (ja) 2012-12-19
US20070149602A1 (en) 2007-06-28
BRPI0513087A (pt) 2008-04-22
AU2005279085B2 (en) 2011-06-16
MA28845B1 (fr) 2007-09-03
ES2318542T3 (es) 2009-05-01
DK1776340T3 (da) 2009-04-06
SI1776340T1 (sl) 2009-04-30
EA200700400A1 (ru) 2007-06-29
UY29046A1 (es) 2006-03-31
AR050283A1 (es) 2006-10-11
EP1776340A1 (fr) 2007-04-25
ECSP077215A (es) 2007-02-28
US20090286846A1 (en) 2009-11-19
US7384969B2 (en) 2008-06-10
CN101010297B (zh) 2011-07-27
AU2005279085A1 (en) 2006-03-09
ATE416160T1 (de) 2008-12-15
PL1776340T3 (pl) 2009-05-29
EA011714B1 (ru) 2009-04-28
US7781477B2 (en) 2010-08-24
PE20060557A1 (es) 2006-08-07
US20080227843A1 (en) 2008-09-18
IL180911A0 (en) 2007-07-04
TW200616954A (en) 2006-06-01
WO2006024776A1 (fr) 2006-03-09
KR20070044000A (ko) 2007-04-26
US7582671B2 (en) 2009-09-01
IL180911A (en) 2011-06-30
HK1110308A1 (xx) 2008-07-11
NO20071198L (no) 2007-03-02
CA2576727A1 (fr) 2006-03-09
UA90483C2 (xx) 2010-05-11
MX2007001436A (es) 2007-04-19
CA2576727C (fr) 2013-11-26
DE602005011450D1 (de) 2009-01-15
ZA200700999B (en) 2008-06-25
FR2874015B1 (fr) 2006-09-15
RS50853B (sr) 2010-08-31
FR2874015A1 (fr) 2006-02-10
CY1108816T1 (el) 2014-04-09
TWI360538B (en) 2012-03-21
TNSN07041A1 (fr) 2008-06-02
KR101215162B1 (ko) 2012-12-24
PT1776340E (pt) 2009-02-20
ME01663B (me) 2010-08-31
NO340060B1 (no) 2017-03-06
NZ552924A (en) 2010-08-27
CR8889A (es) 2007-10-01
CN101010297A (zh) 2007-08-01
JP2008509113A (ja) 2008-03-27
MY139286A (en) 2009-09-30

Similar Documents

Publication Publication Date Title
HRP20090101T3 (en) N-(1h-indolyl)-h-indole-2-carboxamide derivatives, their preparation and their therapeutic use
RS51888B (en) N- (PHENYL (PIPERIDIN-2-IL) METHYL) BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY
RS51358B (en) N- (HETEROARYL) -1H-INDOL-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS A VANYLOID TRPV1 RECEPTOR LIGAND
MEP12608A (en) Derivatives of n-[phenyl (pyrrolidine-2-yl) methyl]benzamide and n-[(azepan-2-yl)phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics
MEP22008A (en) Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
AR055878A1 (es) Derivados de ciclopropanocarboxamida
RS50980B (sr) Derivati n-hidroksiamida i njihova upotreba
HRP20080339T3 (en) N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
AR049739A1 (es) Derivados de aril-piridina
BRPI0407501A (pt) glicolipìdeos e método sintético dos mesmos bem como seus intermediários sintéticos, e método sintético dos mesmos
HUP0402507A2 (hu) N(fenilszulfonil)glicin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények
ES2195571T3 (es) Nuevos benzonaftiridin-n-oxidos.
PE20070751A1 (es) Derivados de isoxazolidina como inhibidores de la interaccion de proteinas bcl
AR052866A1 (es) Fenil-metanonas monociclicas sustituidas
RS52702B (en) CARBASOL UNITS AND THERAPEUTIC USE OF THE COMPOUNDS
HRP20021023B1 (en) Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders
HRP20050775A2 (en) Quinolinone/benzoxazinone derivatives and uses thereof
YU39698A (sh) Hinoksalindioni
YU40998A (sh) Derivati supstituisanog 1,2,3,4-tetrahidronaftalina
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
SE0400043D0 (sv) New compounds
AR058110A1 (es) Derivados de piperidina
HUP0303568A2 (hu) Benzotiofénszármazékok, eljárás előállításukra és alkalmazásuk
BRPI0511581A (pt) derivados de tetrahidroisoquinolilsulfonamidas, sua preparação e sua utilização em terapêutica
TW200612931A (en) Substituted biphenyl derivatives