AR050283A1 - Derivados de n-(1h-indolil)-1h-indol-2-carboxamidas, su preparacion y su aplicacion en terapeuticas. - Google Patents

Derivados de n-(1h-indolil)-1h-indol-2-carboxamidas, su preparacion y su aplicacion en terapeuticas.

Info

Publication number
AR050283A1
AR050283A1 ARP050103236A ARP050103236A AR050283A1 AR 050283 A1 AR050283 A1 AR 050283A1 AR P050103236 A ARP050103236 A AR P050103236A AR P050103236 A ARP050103236 A AR P050103236A AR 050283 A1 AR050283 A1 AR 050283A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
cycloalkyl
atom
aryl
Prior art date
Application number
ARP050103236A
Other languages
English (en)
Inventor
Laurent Dubois
Yannick Evanno
Luc Even
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR050283A1 publication Critical patent/AR050283A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a los compuestos de formula general (1) en la cual X1, X2, X3, X4, Z1, Z2, Z3, Z4 y Z5 representan, independientemente entre sí, un átomo de H o de halogeno, o un grupo alquilo C1-6, cicloalquilo C3-7, fluoroalquilo C1-6, alcoxi C1-6, fluoroalcoxi C1-6, ciano, C(O)NR1R2, nitro, NR1R2, tioalquilo C1-6, -S(O)-alquilo C1-6, -S(O)2-alquilo C1-6, SO2NR1R2, NR3COR4, NR3SO2R5 o arilo; X5 representa un átomo de H o de halogeno, o un grupo alquilo C1-6, fluoroalquilo C1-6; R representa un grupo 4-, 5-, 6- o 7-indolilo, eventualmente substituido; Y representa un átomo H o un grupo alquilo C1-6; n es igual a 0, 1, 2, o 3; R1 y R2, representan, independientemente entre sí, un átomo de H o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3, o arilo; o R1 y R2 forman junto con el átomo de N que los transporta, un grupo azetidina, pirrolidina, piperidina, azepina, morfolina, tiomorfolina, piperazina, homopiperazina, y ese grupo está substituido, eventualmente, por un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3 o arilo; R3 y R4, representan, independientemente entre sí, un átomo de H o un grupo alquilo C1-6 o arilo; R5 representa un grupo alquilo C1-6 o arilo; en estado de base o de sal de adicion co un ácido, así como en estado de hidrato o de solvato. Procedimiento de preparacion y aplicacion en terapéutica.
ARP050103236A 2004-08-05 2005-08-04 Derivados de n-(1h-indolil)-1h-indol-2-carboxamidas, su preparacion y su aplicacion en terapeuticas. AR050283A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0408652A FR2874015B1 (fr) 2004-08-05 2004-08-05 Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR050283A1 true AR050283A1 (es) 2006-10-11

Family

ID=34950701

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103236A AR050283A1 (es) 2004-08-05 2005-08-04 Derivados de n-(1h-indolil)-1h-indol-2-carboxamidas, su preparacion y su aplicacion en terapeuticas.

Country Status (37)

Country Link
US (3) US7384969B2 (es)
EP (1) EP1776340B1 (es)
JP (1) JP5100381B2 (es)
KR (1) KR101215162B1 (es)
CN (1) CN101010297B (es)
AR (1) AR050283A1 (es)
AT (1) ATE416160T1 (es)
AU (1) AU2005279085B2 (es)
BR (1) BRPI0513087A (es)
CA (1) CA2576727C (es)
CR (1) CR8889A (es)
CY (1) CY1108816T1 (es)
DE (1) DE602005011450D1 (es)
DK (1) DK1776340T3 (es)
EA (1) EA011714B1 (es)
EC (1) ECSP077215A (es)
ES (1) ES2318542T3 (es)
FR (1) FR2874015B1 (es)
HR (1) HRP20090101T3 (es)
IL (1) IL180911A (es)
MA (1) MA28845B1 (es)
ME (1) ME01663B (es)
MX (1) MX2007001436A (es)
MY (1) MY139286A (es)
NO (1) NO340060B1 (es)
NZ (1) NZ552924A (es)
PE (1) PE20060557A1 (es)
PL (1) PL1776340T3 (es)
PT (1) PT1776340E (es)
RS (1) RS50853B (es)
SI (1) SI1776340T1 (es)
TN (1) TNSN07041A1 (es)
TW (1) TWI360538B (es)
UA (1) UA90483C2 (es)
UY (1) UY29046A1 (es)
WO (1) WO2006024776A1 (es)
ZA (1) ZA200700999B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
FR2910473B1 (fr) 2006-12-26 2009-02-13 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
FR2911604B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
BRPI0812594A2 (pt) * 2007-08-10 2015-06-23 Lundbeck & Co As H Composto ou sal ou hidrato do mesmo, composição farmacêutica, métodos para modulação da atividade de um receptor p2x7, para tratamento de uma condição responsiva á modulação do receptor p2x7 em um paciente, para inibição de morte de células gangliônicas retinais em um paciente, para determinação da presença ou ausência de receptor p2x7 em uma amostra, preparação farmacêutica acondicionada, e, uso de um composto ou sal ou hidrato do mesmo.
JP5562865B2 (ja) 2007-12-17 2014-07-30 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Trpv1のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926556B1 (fr) * 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2926555B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
US20100210682A1 (en) * 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
FR3007850B1 (fr) 2013-06-28 2015-07-17 Probayes Systeme de prediction de temperature

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
DK0885215T3 (da) * 1996-02-13 2006-08-14 Abbott Lab Nye benzo-1,3-dioxolyl- og benzofuranyl-substituerede pyrrolidinderivater som endthelinantagonister
TR200101233T2 (tr) * 1997-08-04 2002-06-21 Abbott Laboratories Endotelin antagonistleri.
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
AU2002364549B2 (en) * 2001-12-10 2007-11-22 Amgen, Inc Vanilloid receptor ligands and their use in treatments
JP2005531574A (ja) * 2002-05-22 2005-10-20 アムジエン・インコーポレーテツド 痛みの治療にバニロイド受容体リガンドとして使用するためのアミノ−ピリジン、−ピリジンおよびピリダジン誘導体
EP1578418A2 (en) * 2002-12-20 2005-09-28 Bayer HealthCare AG Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
ES2337254T3 (es) 2003-02-14 2010-04-22 Glaxo Group Limited Derivados de carboxamida.
US7544803B2 (en) * 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL180911A0 (en) 2007-07-04
KR20070044000A (ko) 2007-04-26
ECSP077215A (es) 2007-02-28
EA011714B1 (ru) 2009-04-28
UY29046A1 (es) 2006-03-31
NO20071198L (no) 2007-03-02
EA200700400A1 (ru) 2007-06-29
US20070149602A1 (en) 2007-06-28
CA2576727A1 (fr) 2006-03-09
US20080227843A1 (en) 2008-09-18
PE20060557A1 (es) 2006-08-07
TNSN07041A1 (fr) 2008-06-02
FR2874015B1 (fr) 2006-09-15
TW200616954A (en) 2006-06-01
CN101010297A (zh) 2007-08-01
MA28845B1 (fr) 2007-09-03
CR8889A (es) 2007-10-01
EP1776340B1 (fr) 2008-12-03
JP2008509113A (ja) 2008-03-27
AU2005279085B2 (en) 2011-06-16
CN101010297B (zh) 2011-07-27
WO2006024776A1 (fr) 2006-03-09
EP1776340A1 (fr) 2007-04-25
TWI360538B (en) 2012-03-21
US7781477B2 (en) 2010-08-24
US7582671B2 (en) 2009-09-01
CY1108816T1 (el) 2014-04-09
RS50853B (sr) 2010-08-31
SI1776340T1 (sl) 2009-04-30
ZA200700999B (en) 2008-06-25
PL1776340T3 (pl) 2009-05-29
AU2005279085A1 (en) 2006-03-09
NO340060B1 (no) 2017-03-06
DE602005011450D1 (de) 2009-01-15
MY139286A (en) 2009-09-30
MX2007001436A (es) 2007-04-19
ATE416160T1 (de) 2008-12-15
HK1110308A1 (en) 2008-07-11
UA90483C2 (uk) 2010-05-11
FR2874015A1 (fr) 2006-02-10
BRPI0513087A (pt) 2008-04-22
HRP20090101T3 (en) 2009-03-31
JP5100381B2 (ja) 2012-12-19
US20090286846A1 (en) 2009-11-19
KR101215162B1 (ko) 2012-12-24
DK1776340T3 (da) 2009-04-06
PT1776340E (pt) 2009-02-20
CA2576727C (fr) 2013-11-26
IL180911A (en) 2011-06-30
ME01663B (me) 2010-08-31
ES2318542T3 (es) 2009-05-01
US7384969B2 (en) 2008-06-10
NZ552924A (en) 2010-08-27

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