HRP20090005T3 - Biciklički heterociklički spojevi kao inhibitori hiv integraze - Google Patents

Biciklički heterociklički spojevi kao inhibitori hiv integraze

Info

Publication number
HRP20090005T3
HRP20090005T3 HR20090005T HRP20090005T HRP20090005T3 HR P20090005 T3 HRP20090005 T3 HR P20090005T3 HR 20090005 T HR20090005 T HR 20090005T HR P20090005 T HRP20090005 T HR P20090005T HR P20090005 T3 HRP20090005 T3 HR P20090005T3
Authority
HR
Croatia
Prior art keywords
alkyl
hydrogen
alkoxy
6alkyl
cyano
Prior art date
Application number
HR20090005T
Other languages
English (en)
Croatian (hr)
Inventor
B. Naidu Narasimhulu
Banville Jacques
Beaulieu Francis
P. Connolly Timothy
R. Krystal Mark
D. Matiskella John
Ouellet Carl
Plamondon Serge
Remillard Roger
E. Sorenson Margaret
Ueda Yasutsugu
A. Walker Michael
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HRP20090005T3 publication Critical patent/HRP20090005T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20090005T 2004-05-28 2005-05-12 Biciklički heterociklički spojevi kao inhibitori hiv integraze HRP20090005T3 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57551304P 2004-05-28 2004-05-28
US60337104P 2004-08-20 2004-08-20
US11/126,891 US7176196B2 (en) 2004-05-28 2005-05-11 Bicyclic heterocycles as HIV integrase inhibitors
PCT/US2005/016473 WO2005118593A1 (en) 2004-05-28 2005-05-12 Bicyclic heterocycles as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
HRP20090005T3 true HRP20090005T3 (hr) 2009-02-28

Family

ID=35456854

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090005T HRP20090005T3 (hr) 2004-05-28 2005-05-12 Biciklički heterociklički spojevi kao inhibitori hiv integraze

Country Status (26)

Country Link
US (2) US7176196B2 (https=)
EP (1) EP1749011B1 (https=)
JP (1) JP4874959B2 (https=)
KR (1) KR101097623B1 (https=)
AR (1) AR049124A1 (https=)
AT (1) ATE412656T1 (https=)
AU (1) AU2005250356C1 (https=)
BR (1) BRPI0511623A (https=)
CA (1) CA2568356C (https=)
CY (1) CY1110266T1 (https=)
DE (1) DE602005010690D1 (https=)
DK (1) DK1749011T3 (https=)
ES (1) ES2315875T3 (https=)
HR (1) HRP20090005T3 (https=)
IL (1) IL179455A (https=)
MX (1) MXPA06013835A (https=)
NO (1) NO20065879L (https=)
NZ (1) NZ551282A (https=)
PE (1) PE20060242A1 (https=)
PL (1) PL1749011T3 (https=)
PT (1) PT1749011E (https=)
RS (1) RS50700B (https=)
RU (1) RU2381228C2 (https=)
SI (1) SI1749011T1 (https=)
TW (1) TWI366567B (https=)
WO (1) WO2005118593A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
CA2600832C (en) * 2005-03-31 2011-12-13 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors
US7494984B2 (en) * 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
US7939537B2 (en) 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064316A1 (en) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Bicyclic heterocycles as hiv integrase inhibitors
US20070129379A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
WO2007064502A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide
WO2007143446A1 (en) * 2006-05-30 2007-12-13 Bristol-Myers Squibb Company Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
JP2009543865A (ja) * 2006-07-19 2009-12-10 ユニバーシティ オブ ジョージア リサーチ ファウンデーション， インコーポレーテッド ピリジノンジケト酸：併用療法におけるｈｉｖ複製の阻害剤
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2009120841A1 (en) * 2008-03-27 2009-10-01 Bristol-Myers Squibb Company Crystalline form of n-[[4-fluoro-2-(5-methyl-1h-1,2,4-triazol-1-yl)phenyl]methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide, sodium salt monohydrate
WO2010042391A2 (en) * 2008-10-06 2010-04-15 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
ES2446720T3 (es) 2009-10-13 2014-03-10 Elanco Animal Health Ireland Limited Inhibidores de la integrasa macrocíclica
US8383639B2 (en) 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
EA201270651A1 (ru) 2009-12-07 2013-01-30 Юниверсити Оф Джорджия Рисерч Фаундейшн, Инк. Карбоксамиды пиридинон гидроксициклопентила: ингибиторы вич интегразы и области терапевтического применения
LT3494972T (lt) 2010-01-27 2024-03-12 Viiv Healthcare Company Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
WO2011121105A1 (en) 2010-04-02 2011-10-06 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
JP5996532B2 (ja) 2010-07-15 2016-09-21 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 有害生物防除剤としての新規複素環式化合物
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
ES3018133T3 (en) 2011-11-30 2025-05-14 Univ Emory Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
WO2013111118A2 (en) * 2012-01-26 2013-08-01 Cro Consulting Limited Agents for treating neurodegenerative disorders
EP2931730B1 (en) 2012-12-17 2019-08-07 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
US9493479B2 (en) 2013-04-16 2016-11-15 Merck Sharp & Dohme Corp. Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
RS56701B1 (sr) 2013-05-17 2018-03-30 Merck Sharp & Dohme Fuzionisana triciklična heterociklična jedinjenja kao inhibitori hiv integraze
EP3008044B1 (en) 2013-06-13 2018-11-21 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
UA117499C2 (uk) 2013-09-27 2018-08-10 Мерк Шарп Енд Доум Корп. Заміщені похідні хінолізину, які можна використовувати як інгібітори інтегрази віл
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
US10548910B2 (en) 2015-11-17 2020-02-04 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
US10544155B2 (en) 2015-12-15 2020-01-28 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
CA3042314A1 (en) 2016-12-02 2018-06-07 Merck Sharp & Dohme Corp. Tricyclic heterocycle compounds useful as hiv integrase inhibitors
EP3573984A4 (en) 2017-01-26 2020-07-29 Merck Sharp & Dohme Corp. USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS
WO2021050555A1 (en) * 2019-09-10 2021-03-18 X-Chem, Inc. Compositions and uses thereof
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693641A (en) * 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
ATE355064T1 (de) 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
IL161337A0 (en) 2001-10-26 2004-09-27 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
EP1539762A2 (en) 2002-06-26 2005-06-15 Bristol-Myers Squibb Company Bicyclic pyrimidinones as coagulation cascade inhibitors
NZ540729A (en) 2002-12-27 2008-03-28 Angeletti P Ist Richerche Bio Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds useful as HIV integrase inhibitors
AR046938A1 (es) 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
BRPI0518741A2 (pt) 2004-12-03 2008-12-02 Merck & Co Inc uso de uma combinaÇço de uma droga diretamente metabolizada por ugt1a1 ou um seu sal farmaceuticamente aceitÁvel e atazanavir ou um seu sal farmaceuticamente aceitÁvel, e, combinaÇço farmacÊutica para administraÇço oral a um mamÍfero
CA2600832C (en) 2005-03-31 2011-12-13 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors

Also Published As

Publication number Publication date
AR049124A1 (es) 2006-06-28
EP1749011A1 (en) 2007-02-07
EP1749011B1 (en) 2008-10-29
AU2005250356B2 (en) 2011-03-17
IL179455A (en) 2011-10-31
SI1749011T1 (sl) 2009-08-31
US20060276466A1 (en) 2006-12-07
RS50700B (sr) 2010-06-30
PL1749011T3 (pl) 2009-04-30
CY1110266T1 (el) 2015-01-14
US7511037B2 (en) 2009-03-31
WO2005118593A1 (en) 2005-12-15
JP2008501018A (ja) 2008-01-17
RU2381228C2 (ru) 2010-02-10
TWI366567B (en) 2012-06-21
NZ551282A (en) 2009-05-31
JP4874959B2 (ja) 2012-02-15
TW200600503A (en) 2006-01-01
CA2568356A1 (en) 2005-12-15
HK1107343A1 (en) 2008-04-03
PE20060242A1 (es) 2006-03-31
DK1749011T3 (da) 2009-02-16
NO20065879L (no) 2007-02-20
RU2006146970A (ru) 2008-07-10
PT1749011E (pt) 2008-11-27
KR20070039502A (ko) 2007-04-12
US7176196B2 (en) 2007-02-13
KR101097623B1 (ko) 2011-12-22
IL179455A0 (en) 2007-05-15
US20050267105A1 (en) 2005-12-01
BRPI0511623A (pt) 2008-03-11
DE602005010690D1 (de) 2008-12-11
MXPA06013835A (es) 2007-02-02
ES2315875T3 (es) 2009-04-01
CA2568356C (en) 2012-07-03
ATE412656T1 (de) 2008-11-15
AU2005250356C1 (en) 2011-10-06
AU2005250356A1 (en) 2005-12-15

Similar Documents

Publication Publication Date Title
HRP20090005T3 (hr) Biciklički heterociklički spojevi kao inhibitori hiv integraze
CO6220851A2 (es) Compuestos de ciclohexandiona sustituidos en la posicion 5
RU2009139920A (ru) Изоксазолиновые соединения и их применение в борьбе с вредителями
BG106473A (en) Uracil substituted phenyl sulfamoyl carboxamides
HRP20030448B1 (en) Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitors
MEP22008A (en) Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
CO6440540A2 (es) Nuevas pirazol-4-n-alcoxicarboxamidas como microbicidas
DK146488D0 (da) Pyrazolderivater, fremgangsmaade til fremstilling af samme og herbicidesammensaetninger indeholdende disse
MX2011007859A (es) Compuesto de hidrazida y su uso en el control de plagas.
EA200401381A1 (ru) 3-гетероарилзамещённые изоксазолины
HRP20030281B1 (en) Pesticidal composition
AR044695A1 (es) Derivados de azolidina, utiles como herbicidas.
HRP20100247T1 (hr) Inhibitori hiv integraze
EA200600509A1 (ru) Соединения пиримидотиофена
NO20070457L (no) Pyrazolderivater
HRP20070430T3 (en) (3-oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamide derivatives and related compounds as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity
EA200971061A1 (ru) Пиримидоновые соединения гетероариламидов
TW200744994A (en) Insecticidal 3-acylaminobenzanilides
HRP20070307T3 (hr) Derivati n-[fenil(pirolidin-2-il)metil]benzamida i n-[(azepan-2-il)fenilmetil]benzamida, postupak njihovog dobivanja i njihova upotreba u terapiji
NO20044063L (no) Pyranoner anvendelige som ATM-inhibitorer
NO20021294D0 (no) Benzopyranderivat
YU44998A (sh) Pirazolska jedinjenja, postupci za njihovu proizvodnju i herbicidi koji ih sadrže
SE0201937D0 (sv) Therapeutic agents
HRP20050628A2 (en) Substituted benzoyl derivatives uses as herbicides
HRP20020867B1 (en) Synergistic herbicidal mixtures