HRP20080243T3 - 4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors - Google Patents
4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitorsInfo
- Publication number
- HRP20080243T3 HRP20080243T3 HR20080243T HRP20080243T HRP20080243T3 HR P20080243 T3 HRP20080243 T3 HR P20080243T3 HR 20080243 T HR20080243 T HR 20080243T HR P20080243 T HRP20080243 T HR P20080243T HR P20080243 T3 HRP20080243 T3 HR P20080243T3
- Authority
- HR
- Croatia
- Prior art keywords
- alk
- cycloalk
- hydrogen
- independently selected
- yloxy
- Prior art date
Links
- TWNHYHUUTGSBCB-UHFFFAOYSA-N 4-(2-phenylsulfanylphenyl)-1,2,3,6-tetrahydropyridine Chemical class C1NCCC(C=2C(=CC=CC=2)SC=2C=CC=CC=2)=C1 TWNHYHUUTGSBCB-UHFFFAOYSA-N 0.000 title 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46026603P | 2003-04-04 | 2003-04-04 | |
| DKPA200300518 | 2003-04-04 | ||
| PCT/DK2004/000243 WO2004087662A1 (en) | 2003-04-04 | 2004-04-02 | 4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080243T3 true HRP20080243T3 (en) | 2009-04-30 |
Family
ID=35432910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080243T HRP20080243T3 (en) | 2003-04-04 | 2008-06-03 | 4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20070173522A1 (ja) |
| EP (1) | EP1613594B1 (ja) |
| JP (1) | JP2006522029A (ja) |
| KR (1) | KR20060021825A (ja) |
| CN (1) | CN100384822C (ja) |
| AR (1) | AR043964A1 (ja) |
| AT (1) | ATE390413T1 (ja) |
| AU (1) | AU2004226319A1 (ja) |
| BR (1) | BRPI0408453A (ja) |
| CA (1) | CA2521172A1 (ja) |
| CL (1) | CL2004000730A1 (ja) |
| CO (1) | CO5700777A2 (ja) |
| DE (1) | DE602004012724T2 (ja) |
| DK (1) | DK1613594T3 (ja) |
| EA (1) | EA009282B1 (ja) |
| ES (1) | ES2301979T3 (ja) |
| HK (1) | HK1090051A1 (ja) |
| HR (1) | HRP20080243T3 (ja) |
| IS (1) | IS8007A (ja) |
| MX (1) | MXPA05010678A (ja) |
| NO (1) | NO20055205L (ja) |
| NZ (1) | NZ541944A (ja) |
| PL (1) | PL1613594T3 (ja) |
| PT (1) | PT1613594E (ja) |
| SI (1) | SI1613594T1 (ja) |
| UA (1) | UA81300C2 (ja) |
| WO (1) | WO2004087662A1 (ja) |
| ZA (1) | ZA200507182B (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4667366B2 (ja) | 2003-04-04 | 2011-04-13 | ハー・ルンドベック・アクチエゼルスカベット | セロトニン再取り込み阻害剤としての４−（２−フェニルスルファニル−フェニル）−ピペリジン誘導体 |
| EP1792629A4 (en) | 2004-08-25 | 2010-08-25 | Takeda Pharmaceutical | PREVENTIVE / REMEDY AGENTS FOR INCONTINENCE OF STRESS AND SELECETING METHOD THEREOF |
| EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| UA98698C2 (en) * | 2008-03-03 | 2012-06-11 | Х. Луннбек А/С | Phenylsulfanylphenyl-piperidines and process for the preparation thereof |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| EP2930171A1 (en) * | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
| CN105294554B (zh) * | 2015-11-18 | 2017-11-07 | 乳源瑶族自治县大众药品贸易有限公司 | 苯基哌嗪衍生物及其使用方法和用途 |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803143A (en) * | 1969-09-08 | 1974-04-09 | Eisai Co Ltd | 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines |
| US4018830A (en) * | 1969-09-22 | 1977-04-19 | Merck & Co., Inc. | Phenylthioaralkylamines |
| US4055665A (en) * | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
| US4066654A (en) * | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| US4056632A (en) * | 1975-07-21 | 1977-11-01 | Burroughs Wellcome Co. | 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| DE2802306A1 (de) * | 1977-01-27 | 1978-08-10 | Hoechst Ag | Azacycloalkane, azacycloalkene und ihre derivate |
| US4198417A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
| US4198419A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenylthiophenylpiperidines |
| GB8912971D0 (en) * | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| KR100524159B1 (ko) * | 1999-10-13 | 2005-10-25 | 화이자 프로덕츠 인코포레이티드 | 모노아민 재흡수 억제제로서 유용한 비아릴 에테르 유도체 |
| US6410736B1 (en) * | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| CZ20022319A3 (cs) * | 1999-12-30 | 2002-10-16 | H. Lundbeck A/S | Substituovaná fenylpiperazinová sloučenina a farmaceutický prostředek, který ji obsahuje |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
-
2004
- 2004-02-04 UA UAA200508779A patent/UA81300C2/uk unknown
- 2004-04-02 EP EP04725299A patent/EP1613594B1/en not_active Expired - Lifetime
- 2004-04-02 ZA ZA200507182A patent/ZA200507182B/en unknown
- 2004-04-02 CA CA002521172A patent/CA2521172A1/en not_active Abandoned
- 2004-04-02 WO PCT/DK2004/000243 patent/WO2004087662A1/en active IP Right Grant
- 2004-04-02 PL PL04725299T patent/PL1613594T3/pl unknown
- 2004-04-02 US US10/551,869 patent/US20070173522A1/en not_active Abandoned
- 2004-04-02 PT PT04725299T patent/PT1613594E/pt unknown
- 2004-04-02 ES ES04725299T patent/ES2301979T3/es not_active Expired - Lifetime
- 2004-04-02 KR KR1020057018870A patent/KR20060021825A/ko not_active Application Discontinuation
- 2004-04-02 CL CL200400730A patent/CL2004000730A1/es unknown
- 2004-04-02 BR BRPI0408453-5A patent/BRPI0408453A/pt not_active IP Right Cessation
- 2004-04-02 AU AU2004226319A patent/AU2004226319A1/en not_active Abandoned
- 2004-04-02 DK DK04725299T patent/DK1613594T3/da active
- 2004-04-02 JP JP2006504348A patent/JP2006522029A/ja active Pending
- 2004-04-02 DE DE602004012724T patent/DE602004012724T2/de not_active Expired - Fee Related
- 2004-04-02 EA EA200501579A patent/EA009282B1/ru not_active IP Right Cessation
- 2004-04-02 CN CNB2004800094713A patent/CN100384822C/zh not_active Expired - Fee Related
- 2004-04-02 NZ NZ541944A patent/NZ541944A/en unknown
- 2004-04-02 AT AT04725299T patent/ATE390413T1/de not_active IP Right Cessation
- 2004-04-02 MX MXPA05010678A patent/MXPA05010678A/es active IP Right Grant
- 2004-04-02 SI SI200430727T patent/SI1613594T1/sl unknown
- 2004-04-02 AR ARP040101130A patent/AR043964A1/es not_active Application Discontinuation
-
2005
- 2005-08-29 IS IS8007A patent/IS8007A/is unknown
- 2005-11-02 CO CO05111852A patent/CO5700777A2/es unknown
- 2005-11-04 NO NO20055205A patent/NO20055205L/no unknown
-
2006
- 2006-09-26 HK HK06110721A patent/HK1090051A1/xx not_active IP Right Cessation
-
2008
- 2008-06-03 HR HR20080243T patent/HRP20080243T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200507182B (en) | 2006-12-27 |
| PT1613594E (pt) | 2008-07-01 |
| MXPA05010678A (es) | 2005-12-12 |
| AR043964A1 (es) | 2005-08-17 |
| EP1613594A1 (en) | 2006-01-11 |
| CO5700777A2 (es) | 2006-11-30 |
| US20070173522A1 (en) | 2007-07-26 |
| UA81300C2 (en) | 2007-12-25 |
| NO20055205L (no) | 2005-11-04 |
| WO2004087662A1 (en) | 2004-10-14 |
| CL2004000730A1 (es) | 2005-02-18 |
| CN100384822C (zh) | 2008-04-30 |
| AU2004226319A1 (en) | 2004-10-14 |
| ES2301979T3 (es) | 2008-07-01 |
| HK1090051A1 (en) | 2006-12-15 |
| CN1777585A (zh) | 2006-05-24 |
| DE602004012724D1 (de) | 2008-05-08 |
| CA2521172A1 (en) | 2004-10-14 |
| ATE390413T1 (de) | 2008-04-15 |
| EA009282B1 (ru) | 2007-12-28 |
| DK1613594T3 (da) | 2008-07-14 |
| JP2006522029A (ja) | 2006-09-28 |
| KR20060021825A (ko) | 2006-03-08 |
| IS8007A (is) | 2005-08-29 |
| BRPI0408453A (pt) | 2006-04-04 |
| PL1613594T3 (pl) | 2008-09-30 |
| SI1613594T1 (sl) | 2008-08-31 |
| EA200501579A1 (ru) | 2006-04-28 |
| DE602004012724T2 (de) | 2009-04-09 |
| EP1613594B1 (en) | 2008-03-26 |
| NZ541944A (en) | 2008-05-30 |
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