HRP20050223A2 - New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors - Google Patents
New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors Download PDFInfo
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- HRP20050223A2 HRP20050223A2 HR20050223A HRP20050223A HRP20050223A2 HR P20050223 A2 HRP20050223 A2 HR P20050223A2 HR 20050223 A HR20050223 A HR 20050223A HR P20050223 A HRP20050223 A HR P20050223A HR P20050223 A2 HRP20050223 A2 HR P20050223A2
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- alkyl
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- compound
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- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title description 2
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title description 2
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 68
- 150000001875 compounds Chemical class 0.000 claims description 66
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 229940123304 Phosphodiesterase 7 inhibitor Drugs 0.000 claims description 12
- 125000004429 atom Chemical group 0.000 claims description 12
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- 229910052717 sulfur Inorganic materials 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
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- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 claims description 8
- 150000002391 heterocyclic compounds Chemical class 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
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- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020292275 EP1400244A1 (en) | 2002-09-17 | 2002-09-17 | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
| PCT/IB2003/003965 WO2004026818A1 (en) | 2002-09-17 | 2003-09-08 | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20050223A2 true HRP20050223A2 (en) | 2005-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050223A HRP20050223A2 (en) | 2002-09-17 | 2005-03-08 | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
Country Status (30)
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| US (1) | US7429598B2 (es) |
| EP (2) | EP1400244A1 (es) |
| JP (1) | JP2006501277A (es) |
| KR (1) | KR20050057371A (es) |
| CN (1) | CN1681507A (es) |
| AP (1) | AP2005003251A0 (es) |
| AR (1) | AR041271A1 (es) |
| AU (1) | AU2003259496A1 (es) |
| BR (1) | BR0314379A (es) |
| CA (1) | CA2499330C (es) |
| CO (1) | CO5540391A2 (es) |
| CR (1) | CR7728A (es) |
| EA (1) | EA200500312A1 (es) |
| EC (1) | ECSP055671A (es) |
| GT (1) | GT200300201A (es) |
| HN (1) | HN2003000285A (es) |
| HR (1) | HRP20050223A2 (es) |
| IS (1) | IS7700A (es) |
| MA (1) | MA27439A1 (es) |
| MX (1) | MXPA05002913A (es) |
| NO (1) | NO20051695L (es) |
| OA (1) | OA12924A (es) |
| PA (1) | PA8582801A1 (es) |
| PE (1) | PE20050073A1 (es) |
| PL (1) | PL375977A1 (es) |
| TN (1) | TNSN05073A1 (es) |
| TW (1) | TWI251590B (es) |
| UY (1) | UY27986A1 (es) |
| WO (1) | WO2004026818A1 (es) |
| ZA (1) | ZA200501381B (es) |
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| EP1511488B1 (en) | 2002-06-12 | 2013-05-22 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| GB0504209D0 (en) * | 2005-03-01 | 2005-04-06 | Pfizer Ltd | New use of PDE7 inhibitors |
| WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
| US20090111837A1 (en) * | 2005-03-01 | 2009-04-30 | Peter Cox | Use of pde7 inhibitors for the treatment of neuropathic pain |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| EP1957467A2 (en) | 2005-12-02 | 2008-08-20 | Pfizer Limited | Spirocyclic derivatives |
| EP1984333B1 (en) | 2006-02-03 | 2012-04-25 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| WO2008119057A2 (en) | 2007-03-27 | 2008-10-02 | Omeros Corporation | The use of pde7 inhibitors for the treatment of movement disorders |
| JP2010527986A (ja) * | 2007-05-24 | 2010-08-19 | ファイザー・リミテッド | スピロ環状キナゾリン誘導体およびｐｄｅ７阻害剤としてのその使用 |
| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| CN101743242A (zh) * | 2007-06-29 | 2010-06-16 | 苏尼西斯制药有限公司 | 用作raf激酶抑制剂的杂环化合物 |
| JP5984389B2 (ja) | 2008-08-06 | 2016-09-06 | ビオマリン プハルマセウトイカル インコーポレイテッド | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| CA2787844C (en) | 2010-02-03 | 2019-08-27 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency |
| US20110190266A1 (en) * | 2010-02-04 | 2011-08-04 | Daniel Chu | 5,6,6a,7,8,9-HEXAHYDRO-2H-PYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) |
| JP5735988B2 (ja) * | 2010-02-08 | 2015-06-17 | ビオマリン プハルマセウトイカル インコーポレイテッド | ジヒドロピリドフタラジノン誘導体を合成する方法 |
| BR112013009117A2 (pt) | 2010-10-21 | 2016-07-19 | Biomarin Pharm Inc | sal tosilato de (8s,9r)-5-fluor-8-(4-fluorefenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-diidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona, método para preparar uma forma cristalina e uso do mesmo,composição farmacêutica e método para tratar um câncer ou um sintoma do mesmo. |
| CN103547267A (zh) | 2010-11-08 | 2014-01-29 | 奥默罗斯公司 | 使用pde7抑制剂治疗成瘾和冲动控制障碍 |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| CA3069432A1 (en) | 2017-07-12 | 2019-01-17 | Dart Neuroscience, Llc | Substituted benzoxazole and benzofuran compounds as pde7 inhibitors |
| CN112574202B (zh) * | 2020-12-11 | 2021-11-09 | 台州学院 | 一种螺喹唑啉-2-酮类衍生物及其制备方法和应用 |
| WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (10)
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| JPS5959685A (ja) * | 1982-09-28 | 1984-04-05 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| JPS5959865A (ja) * | 1982-09-30 | 1984-04-05 | Ube Ind Ltd | 耐熱鋳鋼 |
| US4906630A (en) * | 1985-11-22 | 1990-03-06 | Rorer Pharmaceutical Corporation | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds |
| US4666913A (en) * | 1985-11-22 | 1987-05-19 | William H. Rorer, Inc. | Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses |
| US4764512A (en) | 1986-08-27 | 1988-08-16 | Rorer Pharmaceutical Corporation | Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses |
| US5102886A (en) | 1990-10-12 | 1992-04-07 | American Home Products Corporation | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
| IL102764A0 (en) * | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
| WO2000066560A1 (en) | 1999-05-04 | 2000-11-09 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| AP1699A (en) * | 2001-03-21 | 2006-12-26 | Warner Lambert Co | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors |
| US6596167B2 (en) | 2001-03-26 | 2003-07-22 | Koch Membrane Systems, Inc. | Hydrophilic hollow fiber ultrafiltration membranes that include a hydrophobic polymer and a method of making these membranes |
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2003
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Also Published As
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| BR0314379A (pt) | 2005-07-19 |
| CA2499330A1 (en) | 2004-04-01 |
| EP1542694A1 (en) | 2005-06-22 |
| UY27986A1 (es) | 2004-04-30 |
| IS7700A (is) | 2005-02-17 |
| MXPA05002913A (es) | 2005-05-27 |
| AR041271A1 (es) | 2005-05-11 |
| EP1400244A1 (en) | 2004-03-24 |
| EA200500312A1 (ru) | 2005-08-25 |
| US7429598B2 (en) | 2008-09-30 |
| CO5540391A2 (es) | 2005-07-29 |
| AU2003259496A1 (en) | 2004-04-08 |
| PL375977A1 (en) | 2005-12-12 |
| JP2006501277A (ja) | 2006-01-12 |
| MA27439A1 (fr) | 2005-07-01 |
| AP2005003251A0 (en) | 2005-03-31 |
| OA12924A (en) | 2006-10-13 |
| ECSP055671A (es) | 2005-05-30 |
| ZA200501381B (en) | 2006-11-29 |
| GT200300201A (es) | 2004-05-18 |
| US20040106631A1 (en) | 2004-06-03 |
| NO20051695L (no) | 2005-04-05 |
| KR20050057371A (ko) | 2005-06-16 |
| CN1681507A (zh) | 2005-10-12 |
| CA2499330C (en) | 2009-04-28 |
| WO2004026818A1 (en) | 2004-04-01 |
| TW200413333A (en) | 2004-08-01 |
| PA8582801A1 (es) | 2004-05-26 |
| HN2003000285A (es) | 2004-11-23 |
| TWI251590B (en) | 2006-03-21 |
| CR7728A (es) | 2005-06-08 |
| TNSN05073A1 (fr) | 2007-05-14 |
| PE20050073A1 (es) | 2005-02-28 |
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