HRP20041132A2 - 7-aryl-3, 9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases - Google Patents
7-aryl-3, 9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseasesInfo
- Publication number
- HRP20041132A2 HRP20041132A2 HR20041132A HRP20041132A HRP20041132A2 HR P20041132 A2 HRP20041132 A2 HR P20041132A2 HR 20041132 A HR20041132 A HR 20041132A HR P20041132 A HRP20041132 A HR P20041132A HR P20041132 A2 HRP20041132 A2 HR P20041132A2
- Authority
- HR
- Croatia
- Prior art keywords
- diazabicyclo
- hypertension
- cardiovascular
- aryl
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0204705 | 2002-04-29 | ||
PCT/EP2003/003721 WO2003093267A1 (en) | 2002-04-29 | 2003-04-08 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20041132A2 true HRP20041132A2 (en) | 2006-07-31 |
Family
ID=29286070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20041132A HRP20041132A2 (en) | 2002-04-29 | 2004-11-25 | 7-aryl-3, 9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
Country Status (26)
Country | Link |
---|---|
US (2) | US7427613B2 (is) |
EP (1) | EP1501830B1 (is) |
JP (1) | JP4041123B2 (is) |
KR (1) | KR100783863B1 (is) |
CN (1) | CN1649870A (is) |
AT (1) | ATE527261T1 (is) |
AU (1) | AU2003233963B2 (is) |
BR (1) | BR0309498A (is) |
CA (1) | CA2483241C (is) |
CL (1) | CL2003002042A1 (is) |
CO (1) | CO5631443A2 (is) |
EC (1) | ECSP045378A (is) |
ES (1) | ES2372931T3 (is) |
HR (1) | HRP20041132A2 (is) |
IL (1) | IL164767A0 (is) |
IS (1) | IS7545A (is) |
MA (1) | MA27305A1 (is) |
MX (1) | MXPA04010608A (is) |
NO (1) | NO20045042L (is) |
NZ (1) | NZ536750A (is) |
PL (1) | PL372141A1 (is) |
RU (1) | RU2343153C2 (is) |
TW (1) | TW200514786A (is) |
UA (1) | UA80821C2 (is) |
WO (1) | WO2003093267A1 (is) |
ZA (1) | ZA200408283B (is) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006524656A (ja) * | 2003-04-28 | 2006-11-02 | アクテリオン ファマシューティカルズ リミテッド | 新規ジアザビシクロノネンおよびテトラヒドロピリジン誘導体 |
JP2006524655A (ja) * | 2003-04-30 | 2006-11-02 | アクテリオン ファマシューティカルズ リミテッド | 3−位にヘテロ原子を有する新規9−アザビシクロノネン誘導体 |
WO2004096799A1 (en) * | 2003-04-30 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Tropane derivatives and their use as ace inhibitors |
CA2521924A1 (en) * | 2003-04-30 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Azabicyclononene derivatives |
RU2005137571A (ru) * | 2003-05-02 | 2006-05-10 | Актелион Фармасьютикалз Лтд. (Ch) | Новые производные диазабициклононена |
WO2004105762A1 (en) * | 2003-05-30 | 2004-12-09 | Actelion Pharmaceuticals Ltd | Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases |
AU2004283814A1 (en) * | 2003-10-09 | 2005-05-06 | Actelion Pharmaceuticals Ltd. | Tetrahydropyridine derivatives |
EP1678176A1 (en) * | 2003-10-13 | 2006-07-12 | Actelion Pharmaceuticals Ltd. | Diazabicyclononene derivatives and their use as renin inhibitors |
EP1680427A1 (en) * | 2003-10-23 | 2006-07-19 | Actelion Pharmaceuticals Ltd. | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
CA2547551A1 (en) * | 2003-12-05 | 2005-06-16 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives with a new side-chain |
US20070111989A1 (en) * | 2003-12-05 | 2007-05-17 | Olivier Bezencon | Novel diazabicyclononene derivatives and use |
WO2006021403A1 (en) * | 2004-08-25 | 2006-03-02 | Actelion Pharmaceuticals Ltd | Bicyclononene derivatives |
WO2006021399A2 (en) * | 2004-08-25 | 2006-03-02 | Actelion Pharmaceuticals Ltd | Azabicyclononene derivatives as renin inhibitors |
WO2006021401A2 (en) * | 2004-08-25 | 2006-03-02 | Actelion Pharmaceuticals Ltd | Bicylononene derivatives |
ATE462703T1 (de) * | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
AR052263A1 (es) * | 2004-12-08 | 2007-03-07 | Actelion Pharmaceuticals Ltd | Derivado de diazabiciclononeno |
WO2006063610A1 (en) * | 2004-12-17 | 2006-06-22 | Actelion Pharmaceuticals Ltd | Heteroaryl substituted diazabicyclononene derivatives |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
CA2595986A1 (en) * | 2005-01-28 | 2006-08-03 | Actelion Pharmaceuticals Ltd | 7-{4-[2-(2,6-dichlor0-4-methylphenoxy)-ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amides as inhibitors of renin for the treatment of hypertension |
JP4297972B2 (ja) | 2005-05-27 | 2009-07-15 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピペリジンカルボン酸アミド誘導体 |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
US8129411B2 (en) | 2005-12-30 | 2012-03-06 | Novartis Ag | Organic compounds |
JP2009526767A (ja) | 2006-02-02 | 2009-07-23 | アクテリオン ファーマシューティカルズ リミテッド | 新規二級アミン |
EP1994026A2 (en) * | 2006-03-08 | 2008-11-26 | Actelion Pharmaceuticals Ltd. | New amines |
JP2010527942A (ja) | 2007-05-24 | 2010-08-19 | メルク フロスト カナダ リミテツド | 新規類のレニン阻害剤 |
ES2541107T3 (es) | 2007-06-25 | 2015-07-16 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina |
CA2696689A1 (en) | 2007-08-20 | 2009-02-26 | Merck Frosst Canada Ltd. | Renin inhibitors |
ES2548134T3 (es) | 2008-05-05 | 2015-10-14 | Actelion Pharmaceuticals Ltd. | Derivados de piperidina 3,4-sustituida como inhibidores de renina |
CN109721613B (zh) * | 2017-10-27 | 2021-07-30 | 四川科伦博泰生物医药股份有限公司 | 含季铵离子的大环酰胺化合物及其药物组合物和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3509161A (en) * | 1967-07-10 | 1970-04-28 | Boehringer & Soehne Gmbh | 3-phenyl-granatene-(2)-derivatives |
GB9020927D0 (en) | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Pharmaceuticals |
US5268361A (en) * | 1991-06-07 | 1993-12-07 | Sri International | Hydroxyazido derivatives and related compounds as renin inhibitors |
CZ292327B6 (cs) | 1995-09-07 | 2003-09-17 | F. Hoffmann-La Roche Ag | Derivát 4-(oxyalkoxyfenyl)-3-oxypiperidinu, způsob jeho přípravy, meziprodukt pro jeho přípravu a farmaceutický prostředek, který ho obsahuje |
EP0966464B1 (en) | 1997-03-03 | 2003-05-28 | Basilea Pharmaceutica AG | Substituted 2,4-diaminopyrimidines |
US20060223795A1 (en) * | 2003-05-02 | 2006-10-05 | Oliver Bezencon | Novel diazabicyclononene derivatives |
US20070111989A1 (en) * | 2003-12-05 | 2007-05-17 | Olivier Bezencon | Novel diazabicyclononene derivatives and use |
-
2003
- 2003-04-08 EP EP03727287A patent/EP1501830B1/en not_active Expired - Lifetime
- 2003-04-08 BR BR0309498-7A patent/BR0309498A/pt not_active IP Right Cessation
- 2003-04-08 NZ NZ536750A patent/NZ536750A/xx unknown
- 2003-04-08 KR KR1020047016845A patent/KR100783863B1/ko not_active IP Right Cessation
- 2003-04-08 JP JP2004501406A patent/JP4041123B2/ja not_active Expired - Fee Related
- 2003-04-08 CA CA2483241A patent/CA2483241C/en not_active Expired - Fee Related
- 2003-04-08 IL IL16476703A patent/IL164767A0/xx unknown
- 2003-04-08 MX MXPA04010608A patent/MXPA04010608A/es not_active Application Discontinuation
- 2003-04-08 PL PL03372141A patent/PL372141A1/xx not_active Application Discontinuation
- 2003-04-08 WO PCT/EP2003/003721 patent/WO2003093267A1/en active Application Filing
- 2003-04-08 AU AU2003233963A patent/AU2003233963B2/en not_active Ceased
- 2003-04-08 US US10/513,103 patent/US7427613B2/en not_active Expired - Fee Related
- 2003-04-08 ES ES03727287T patent/ES2372931T3/es not_active Expired - Lifetime
- 2003-04-08 CN CNA038097664A patent/CN1649870A/zh active Pending
- 2003-04-08 AT AT03727287T patent/ATE527261T1/de not_active IP Right Cessation
- 2003-04-08 RU RU2004134320/04A patent/RU2343153C2/ru not_active IP Right Cessation
- 2003-08-04 UA UA20041109469A patent/UA80821C2/uk unknown
- 2003-10-10 CL CL200302042A patent/CL2003002042A1/es unknown
- 2003-10-23 TW TW092129421A patent/TW200514786A/zh unknown
-
2004
- 2004-10-13 ZA ZA200408283A patent/ZA200408283B/xx unknown
- 2004-10-22 CO CO04106347A patent/CO5631443A2/es not_active Application Discontinuation
- 2004-10-22 MA MA27914A patent/MA27305A1/fr unknown
- 2004-10-22 EC EC2004005378A patent/ECSP045378A/es unknown
- 2004-11-19 NO NO20045042A patent/NO20045042L/no not_active Application Discontinuation
- 2004-11-22 IS IS7545A patent/IS7545A/is unknown
- 2004-11-25 HR HR20041132A patent/HRP20041132A2/xx not_active Application Discontinuation
-
2008
- 2008-07-07 US US12/168,666 patent/US20080312242A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4041123B2 (ja) | 2008-01-30 |
CN1649870A (zh) | 2005-08-03 |
UA80821C2 (en) | 2007-11-12 |
EP1501830B1 (en) | 2011-10-05 |
CL2003002042A1 (es) | 2005-02-04 |
JP2005527602A (ja) | 2005-09-15 |
TW200514786A (en) | 2005-05-01 |
RU2004134320A (ru) | 2005-08-27 |
PL372141A1 (en) | 2005-07-11 |
NO20045042L (no) | 2004-11-19 |
AU2003233963B2 (en) | 2008-09-11 |
MXPA04010608A (es) | 2004-12-13 |
CA2483241A1 (en) | 2003-11-13 |
BR0309498A (pt) | 2005-02-15 |
CA2483241C (en) | 2011-05-31 |
IS7545A (is) | 2004-11-22 |
CO5631443A2 (es) | 2006-04-28 |
RU2343153C2 (ru) | 2009-01-10 |
US20080312242A1 (en) | 2008-12-18 |
ATE527261T1 (de) | 2011-10-15 |
US20050176700A1 (en) | 2005-08-11 |
MA27305A1 (fr) | 2005-05-02 |
KR100783863B1 (ko) | 2007-12-10 |
ECSP045378A (es) | 2004-11-26 |
AU2003233963A1 (en) | 2003-11-17 |
WO2003093267A1 (en) | 2003-11-13 |
ES2372931T3 (es) | 2012-01-27 |
ZA200408283B (en) | 2006-05-31 |
IL164767A0 (en) | 2005-12-18 |
EP1501830A1 (en) | 2005-02-02 |
US7427613B2 (en) | 2008-09-23 |
KR20040101546A (ko) | 2004-12-02 |
NZ536750A (en) | 2007-02-23 |
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