HRP20040588A2 - Treating muscle wasting with selective androgen receptor modulators - Google Patents
Treating muscle wasting with selective androgen receptor modulatorsInfo
- Publication number
- HRP20040588A2 HRP20040588A2 HR20040588A HRP20040588A HRP20040588A2 HR P20040588 A2 HRP20040588 A2 HR P20040588A2 HR 20040588 A HR20040588 A HR 20040588A HR P20040588 A HRP20040588 A HR P20040588A HR P20040588 A2 HRP20040588 A2 HR P20040588A2
- Authority
- HR
- Croatia
- Prior art keywords
- nhcor
- halogen
- image
- compound
- sarm
- Prior art date
Links
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| AU (1) | AU2002364949C1 (fr) |
| BR (1) | BR0215115A (fr) |
| CA (1) | CA2469340A1 (fr) |
| CY (1) | CY1112509T1 (fr) |
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| PT (1) | PT1463497E (fr) |
| TW (1) | TWI339118B (fr) |
| WO (1) | WO2003049675A2 (fr) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
| US7759520B2 (en) | 1996-11-27 | 2010-07-20 | University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
| US7518013B2 (en) | 2000-08-24 | 2009-04-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators |
| US20090264534A1 (en) * | 1996-11-27 | 2009-10-22 | Dalton James T | Selective androgen receptor modulators |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US8008348B2 (en) * | 2001-12-06 | 2011-08-30 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7547728B2 (en) * | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| EA200901492A1 (ru) | 2002-02-07 | 2010-08-30 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Лечение доброкачественной гиперплазии простаты селективным модулятором рецептора андрогенов (sarm) |
| US7705182B2 (en) | 2002-02-28 | 2010-04-27 | University Of Tennessee Research Foundation | Multi-substituted selective androgen receptor modulators and methods of use thereof |
| US7803970B2 (en) | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| WO2003074449A2 (fr) * | 2002-02-28 | 2003-09-12 | University Of Tennessee Research Foundation | Modulateurs de recepteur selectif d'androgene a substitutions multiples et procedes et utilisations associes |
| EP2266577B8 (fr) * | 2002-02-28 | 2015-01-21 | University Of Tennessee Research Foundation | Modulateurs de récepteur sélectif d'androgène à substitutions multiples et procédé d'utilisation associés |
| AU2003257863A1 (en) * | 2002-08-19 | 2004-03-03 | Nagoya Industrial Science Research Institute | Nonhuman animal reproducing pathogenic conditions of spinal and bulbar muscular atrophy and remedy for spinal and bulbar muscular atrophy |
| CN1726034A (zh) * | 2002-10-15 | 2006-01-25 | 田纳西大学研究基金会 | 亚甲基桥连的选择性雄激素受体调节剂及其应用方法 |
| CA2501874A1 (fr) * | 2002-10-16 | 2004-04-29 | Gtx, Inc. | Traitement d'etats associes au deficit androgenique lie a l'age chez l'homme (adam) au moyen de composes sarm |
| US20060276539A1 (en) * | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| US8309603B2 (en) * | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| FI20030958A0 (fi) * | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
| KR20060035629A (ko) * | 2003-06-27 | 2006-04-26 | 오리온 코포레이션 | 안드로젠 수용체 모듈레이터로 유용한 프로피온아마이드유도체들 |
| CN100462353C (zh) * | 2003-06-27 | 2009-02-18 | 奥赖恩公司 | 用作雄激素受体调节剂的丙酰胺衍生物 |
| AU2004281708B2 (en) * | 2003-10-14 | 2011-02-17 | University Of Tennessee Research Foundation | Treating bone-related disorders with selective androgen receptor modulators |
| MXPA06000119A (es) * | 2003-12-16 | 2006-03-21 | Gtx Inc | Profarmacos de moduladores receptores de androgenos selectivos y metodos de uso de los mismos. |
| EP1737813A1 (fr) * | 2004-04-13 | 2007-01-03 | Warner-Lambert Company LLC | Modulateurs d'androgenes |
| JP4201818B2 (ja) * | 2004-06-07 | 2008-12-24 | ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション | 選択的アンドロゲン受容体調節剤及びその使用方法 |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| WO2006036266A1 (fr) | 2004-07-16 | 2006-04-06 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines utiles en tant qu'inhibiteurs des kinases aurora |
| US7655700B2 (en) * | 2005-08-25 | 2010-02-02 | Michigan State University | Transgenic mouse model and methods for treatment of neuro muscular disease by interfering with androgen-androgen receptor interaction in skeletal muscles |
| ES2453981T3 (es) * | 2005-08-31 | 2014-04-09 | University Of Tennessee Research Foundation | Tratamiento de síntomas de enfermedad renal con moduladores selectivos de receptor de andrógenos (SARM) |
| KR101460999B1 (ko) * | 2006-07-12 | 2014-11-17 | 유니버시티 오브 테네시 리서치 파운데이션 | 치환된 아실아닐리드 및 그의 사용 방법 |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| BRPI0714526A2 (pt) | 2006-08-24 | 2013-04-30 | Univ Tennessee Res Foundation | acilanilidas substituÍdas e seus mÉtodos de uso |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| KR20100049644A (ko) | 2007-08-07 | 2010-05-12 | 다케다 야쿠힌 고교 가부시키가이샤 | 안드로겐 수용체 조절제로서의 피롤리딘-2-온 유도체 |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| PL2205552T3 (pl) * | 2007-09-11 | 2018-07-31 | Gtx, Inc. | Krystaliczny polimorf selektywnych modulatorów receptora androgenowego (R) lub (S)-N-(4-cyjano-3-(trifluorometylo)fenylo)-3-(4-cyjanofenoksy)-2-hydroksy-2-metylopropanamidu |
| EP2222636B1 (fr) | 2007-12-21 | 2013-04-10 | Ligand Pharmaceuticals Inc. | Modulateurs sélectifs du récepteur androgène (sarm) et leurs utilisations |
| WO2011146768A1 (fr) | 2010-05-20 | 2011-11-24 | University Of Iowa Research Foundation | Procédés d'inhibition de l'atrophie musculaire |
| US11090313B2 (en) | 2010-05-20 | 2021-08-17 | University Of Iowa Research Foundation | Methods for inhibiting muscle atrophy |
| WO2012071340A1 (fr) | 2010-11-23 | 2012-05-31 | Metamagnetics Inc. | Module d'antenne de taille réduite, à gain élevé, et à rendement de puissance accru |
| CN104080454B (zh) | 2011-06-06 | 2017-02-15 | 爱荷华大学研究基金会 | 用于抑制肌萎缩的方法 |
| WO2013078372A1 (fr) * | 2011-11-23 | 2013-05-30 | University Of Iowa Research Foundation | Compositions et procédés pour inhiber l'atrophie musculaire et induire l'hypertrophie musculaire |
| EP2834216A1 (fr) * | 2012-04-04 | 2015-02-11 | Catylix Inc. | Modulateurs sélectifs de récepteur d'androgène |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| KR102122941B1 (ko) | 2012-07-13 | 2020-06-15 | 지티엑스, 인코포레이티드 | 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법 |
| JP2015071549A (ja) * | 2013-10-02 | 2015-04-16 | 株式会社ファンケル | アトロジン−１抑制剤 |
| US10441567B2 (en) | 2014-01-17 | 2019-10-15 | Ligand Pharmaceuticals Incorporated | Methods and compositions for modulating hormone levels |
| EP3206675A4 (fr) * | 2014-10-16 | 2018-07-11 | GTx, Inc. | Procédés de traitement de troubles urologiques par des sarms |
| KR101919081B1 (ko) * | 2017-05-11 | 2018-11-16 | (주)녹십자웰빙 | 인간 태반 추출물을 유효성분으로 포함하는 근 위축증 또는 근육감소증의 예방 또는 치료용 및 근육 기능 개선용 조성물 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1360001A (en) | 1971-06-16 | 1974-07-17 | Scherico Ltd | Pharmaceutical compositions comprising substituted anilides |
| US3875229A (en) * | 1972-11-24 | 1975-04-01 | Schering Corp | Substituted carboxanilides |
| JPS6044294B2 (ja) | 1976-04-15 | 1985-10-02 | 帝国臓器製薬株式会社 | アニリド誘導体 |
| US4139638A (en) * | 1976-09-23 | 1979-02-13 | Schering Corporation | Methods for the treatment of hirsutism |
| EP0002309B1 (fr) * | 1977-10-12 | 1982-12-01 | Imperial Chemical Industries Plc | Acylanilides, procédé pour leur préparation et compositions pharmaceutiques et vétérinaires les contenant |
| US4191775A (en) * | 1977-12-15 | 1980-03-04 | Imperial Chemical Industries Limited | Amide derivatives |
| NZ197008A (en) * | 1980-05-22 | 1984-10-19 | Ici Ltd | Acylanilide derivatives and pharmaceutical compositions |
| US4336505A (en) * | 1980-07-14 | 1982-06-22 | John Fluke Mfg. Co., Inc. | Controlled frequency signal source apparatus including a feedback path for the reduction of phase noise |
| JPS57171904A (en) * | 1981-04-15 | 1982-10-22 | Mitsubishi Petrochem Co Ltd | Tri- or tetra-substituted phenoxycarboxylic acid anilide type herbicide |
| ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
| US4633025A (en) | 1985-04-15 | 1986-12-30 | Miles Laboratories, Inc. | Method for preparing (+)R-2-methyl-hexane-1,2-diol |
| GB8617653D0 (en) | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
| GB8617652D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Acylanilide derivatives |
| US5162504A (en) * | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
| US5847076A (en) * | 1993-05-20 | 1998-12-08 | Board Of Regents, The University Of Texas System | Regulators of the proteasome |
| JPH09508125A (ja) | 1994-01-21 | 1997-08-19 | セプラコー，インコーポレイテッド | 光学的純正ｒ−（−）−カソデックスを使用した男性ホルモン依存疾患治療のための方法と組成 |
| US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| US5656651A (en) * | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
| WO1998005962A1 (fr) | 1996-08-02 | 1998-02-12 | Panvera Corporation | Procede de quantification de la fixation par competition de certaines molecules a des proteines en utilisant la polarisation de fluorescence |
| US6995284B2 (en) * | 2000-08-24 | 2006-02-07 | The University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
| US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
| US6492554B2 (en) * | 2000-08-24 | 2002-12-10 | The University Of Tennessee Research Corporation | Selective androgen receptor modulators and methods of use thereof |
| US6160011A (en) * | 1997-05-30 | 2000-12-12 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
| WO1998055153A1 (fr) | 1997-06-04 | 1998-12-10 | The University Of Tennessee Research Corporation | Composes agonistes/antagonistes non steroidiens radiomarques et leur utilisation dans la formation d'images du cancer de la prostate |
| AU775928B2 (en) | 1999-10-14 | 2004-08-19 | Bristol-Myers Squibb Company | Crystallographic structure of the androgen receptor ligand binding domain |
| CA2387570A1 (fr) | 1999-10-19 | 2001-04-26 | Nobex Corporation | Methodes de synthese asymetrique d'enantiomeres de casodex, derives et intermediaires desdits enantiomeres |
| US6593492B1 (en) | 1999-10-27 | 2003-07-15 | Nobex Corporation | Resolution of intermediates in the synthesis of substantially pure bicalutamide |
| US20030069215A1 (en) * | 2001-03-30 | 2003-04-10 | The Government Of The United States Of America, | Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate |
| MXPA02012605A (es) | 2000-06-28 | 2003-05-14 | Squibb Bristol Myers Co | Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso. |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| SI1401801T1 (sl) * | 2000-08-24 | 2007-04-30 | Univ Tennessee Res Foundation | Selektivni modulatorji androgenskega receptorja in postopki za njihovo uporabo |
| US7547728B2 (en) * | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| FI20030958A0 (fi) | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
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