HRP20030381B1 - 3-DEKLADINOZIL 9a-N-KARBAMOIL I 9a-N-TIOKARBAMOILDERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A - Google Patents

3-DEKLADINOZIL 9a-N-KARBAMOIL I 9a-N-TIOKARBAMOILDERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A

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Publication number
HRP20030381B1
HRP20030381B1 HR20030381A HRP20030381A HRP20030381B1 HR P20030381 B1 HRP20030381 B1 HR P20030381B1 HR 20030381 A HR20030381 A HR 20030381A HR P20030381 A HRP20030381 A HR P20030381A HR P20030381 B1 HRP20030381 B1 HR P20030381B1
Authority
HR
Croatia
Prior art keywords
meaning
individual
group
hydrogen
aza
Prior art date
Application number
HR20030381A
Other languages
English (en)
Inventor
Maru�i�-I�tuk Zorica
Kujund�i� Nedjeljko
Mutak Stjepan
Original Assignee
GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. filed Critical GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.
Priority to HR20030381A priority Critical patent/HRP20030381B1/hr
Priority to YUP-2005/0837A priority patent/RS20050837A/sr
Priority to SI200430155T priority patent/SI1631575T1/sl
Priority to CNB2004800130438A priority patent/CN100345860C/zh
Priority to CA002525143A priority patent/CA2525143A1/en
Priority to DE602004003054T priority patent/DE602004003054T2/de
Priority to PT04732143T priority patent/PT1631575E/pt
Priority to PL04732143T priority patent/PL1631575T3/pl
Priority to EP04732143A priority patent/EP1631575B1/en
Priority to PCT/HR2004/000014 priority patent/WO2004101591A1/en
Priority to DK04732143T priority patent/DK1631575T3/da
Priority to ES04732143T priority patent/ES2274453T3/es
Priority to US10/557,025 priority patent/US20070066544A1/en
Priority to AT04732143T priority patent/ATE344270T1/de
Priority to JP2006530610A priority patent/JP2007501268A/ja
Priority to CL200401026A priority patent/CL2004001026A1/es
Priority to ARP040101631A priority patent/AR044320A1/es
Publication of HRP20030381A2 publication Critical patent/HRP20030381A2/hr
Priority to IS8109A priority patent/IS8109A/is
Priority to HK06112660A priority patent/HK1092156A1/xx
Priority to CY20071100033T priority patent/CY1107321T1/el
Publication of HRP20030381B1 publication Critical patent/HRP20030381B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Cosmetics (AREA)

Abstract

Novi 3-dekladinozil 9a-N-karbamoil i 9a-N-tiokarbamoil derivati 9-deokso-9-dihidro-9a-aza-9a-homoeritromicina A opće formule (I), njihove farmaceutski prihvatljive adicione soli s anorganskim i organskim kiselinama i njihovi hidrati, naznačen time daR1 ima individualno značenje vodika ili zajedno sa R2 ima značenje dvostruke veze, R2 ima individualno značenje vodika, hidroksilne grupe ili grupe formule (II), gdjeY ima individualno značenje monocikličkog aromatskog prstena, nesupstituiranog ili supstituiranog grupama koje su neovisno odabrane između halogena, OCH3, NO2, NH2iliR2 zajedno s R3 ima značenje ketona ili zajedno s R1 ima značenje dvostruke veze, R3 ima individualno značenje vodikaili zajedno s R2 ima značenje ketona ili zajedno s R4 ima značenje eterske skupine, R4 ima individualno značenje hidroksilne, OCH3 grupe ili zajedno s R3 ima značenje eterske skupine, R5 ima individualno značenje C1-C4 alkilne grupe, C2-C4 alkenilnegrupe, -(CH2)m-Ar, gdje Ar ima individualno značenje fenila ili fenila supstituiranog s jednom ili dvije grupe koje su neovisno odabrane između halogena ili halogenalkila, a m je 0-3, R6 ima individualno značenje vodika ili hidroksi zaštitne skupine, X ima značenje kisika ili sumpora. Patent sadržijoš 29 patentnih zahtjeva.
HR20030381A 2003-05-14 2003-05-14 3-DEKLADINOZIL 9a-N-KARBAMOIL I 9a-N-TIOKARBAMOILDERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A HRP20030381B1 (hr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
HR20030381A HRP20030381B1 (hr) 2003-05-14 2003-05-14 3-DEKLADINOZIL 9a-N-KARBAMOIL I 9a-N-TIOKARBAMOILDERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A
PCT/HR2004/000014 WO2004101591A1 (en) 2003-05-14 2004-05-11 NEW 3-DECLADINOSYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A-HOMOERYTHROMYCIN A
US10/557,025 US20070066544A1 (en) 2003-05-14 2004-05-11 3-Decladinosyl 9a-n-carbamoyl and 9a-n-thiocarbamoyl derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a
CNB2004800130438A CN100345860C (zh) 2003-05-14 2004-05-11 新的9－脱氧－9－二氢－9A－氮杂－9A－高红霉素A的3－去红霉糖基9a－N－氨基甲酰基和9a－N－硫代氨基甲酰基衍生物
CA002525143A CA2525143A1 (en) 2003-05-14 2004-05-11 New 3-decladinosyl 9a-n-carbamoyl and 9a-n-thiocarbamoyl derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a
DE602004003054T DE602004003054T2 (de) 2003-05-14 2004-05-11 Neue 3-decladinosyl-9a-n-carbamoyl- und 9a-n-thiocarbamoylderivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a
PT04732143T PT1631575E (pt) 2003-05-14 2004-05-11 NOVOS DERIVADOS 3- DECLADINOSIL 9ª-N-CARBAMOIL E 9ª-N- TIOCARBAMOIL DE 9-DESOXI-9-DI-HIDRO-9ª-AZA-9ª-HOMOERITROMICINA
PL04732143T PL1631575T3 (pl) 2003-05-14 2004-05-11 Nowe 3-dekladinozylo-9a-N-karbamoilowe i 9a-N-tiokarbamoilowe pochodne 9-deokso-9-dihydro-9a-aza-9a homoerytromycyny A
EP04732143A EP1631575B1 (en) 2003-05-14 2004-05-11 NEW 3-DECLADINOSYL 9a-N -CARBAMOYL AND 9a-N -THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A-HOMOERYTHROMYCIN A
YUP-2005/0837A RS20050837A (en) 2003-05-14 2004-05-11 NEW 3-DECLADINOSYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A- HOMOERYTHROMYCIN A NEW 3- DECLADINOSYL 9A-N-CARBAMOYL AND -A- N-THIOCARBAMOYL DERIVATIVES OF 9- DEOX-9-DIHYDRO-9A-AZA-9A- HOMOERYTHROMYCIN A
DK04732143T DK1631575T3 (da) 2003-05-14 2004-05-11 Nye 3-decladinosyl-9a-N-carbamoyl- og 9a-N-thiocarbamoylderivater af 9-deox-9-dihydro-9a-AZA-9A-homoerythromycin A
ES04732143T ES2274453T3 (es) 2003-05-14 2004-05-11 Nuevos derivados 3-decladinosil 9a-n-carbamoilicos y 9a-n-tiocarbamoilicos de 9-desoxo-9-dihidro-9a-aza-9a-homoeritromicina a.
SI200430155T SI1631575T1 (sl) 2003-05-14 2004-05-11 NOVI 3-DEKLADINOZIL 9a-N-KARBAMOILNI IN 9a-N-TIOKARBAMOILNI DERIVATI 9-DEOKS-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A
AT04732143T ATE344270T1 (de) 2003-05-14 2004-05-11 Neue 3-decladinosyl-9a-n-carbamoyl- und 9a-n- thiocarbamoylderivate von 9-deoxo-9-dihydro-9a- aza-9a-homoerythromycin a
JP2006530610A JP2007501268A (ja) 2003-05-14 2004-05-11 新規な９−デオキソ−９−ジヒドロ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの３−デクラジノシル９ａ−Ｎ−カルバモイル及び９ａ−Ｎ−チオカルバモイル誘導体
CL200401026A CL2004001026A1 (es) 2003-05-14 2004-05-13 COMPUESTOS DERIVADOS DE 3-DECLADINOSILO DE 9a-N-CARBAMOIL Y 9a-N-TIOCARBAMOIL-9-DEOXO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A; Y PROCEDIMIENTO DE PREPARACION, UTILES COMO AGENTES ANTIBACTERIANOS.
ARP040101631A AR044320A1 (es) 2003-05-14 2004-05-14 Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a
IS8109A IS8109A (is) 2003-05-14 2005-10-31 Nýjar 3-dekladínósýl 9a-N-karbamóýl og 9a-N-þíókarbamóýl afleiður af 9-deoxó-9-díhýdró-9a-asa-9a-hómóerýþrómýsíni A
HK06112660A HK1092156A1 (en) 2003-05-14 2006-11-17 New 3-decladinosyl 9A-N-carbamoyl and 9A-N-thiocarbamoyl derivatives of 9-deox-9-di-hydro-9A-aza-9A homoerythromycin a
CY20071100033T CY1107321T1 (el) 2003-05-14 2007-01-10 Νεα 3-δεκλαδινοσυλ-9α-ν-καρβaμοϋλικα και 9α-ν-θειοκαρβαμοϋλικα παραγωγα της 9-δεσοξο-9-διυδρο-9α-αζα-9α-ομοepυθρομυκινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20030381A HRP20030381B1 (hr) 2003-05-14 2003-05-14 3-DEKLADINOZIL 9a-N-KARBAMOIL I 9a-N-TIOKARBAMOILDERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A

Publications (2)

Publication Number Publication Date
HRP20030381A2 HRP20030381A2 (en) 2005-02-28
HRP20030381B1 true HRP20030381B1 (hr) 2007-05-31

Family

ID=33446264

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030381A HRP20030381B1 (hr) 2003-05-14 2003-05-14 3-DEKLADINOZIL 9a-N-KARBAMOIL I 9a-N-TIOKARBAMOILDERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A

Country Status (20)

Country Link
US (1) US20070066544A1 (hr)
EP (1) EP1631575B1 (hr)
JP (1) JP2007501268A (hr)
CN (1) CN100345860C (hr)
AR (1) AR044320A1 (hr)
AT (1) ATE344270T1 (hr)
CA (1) CA2525143A1 (hr)
CL (1) CL2004001026A1 (hr)
CY (1) CY1107321T1 (hr)
DE (1) DE602004003054T2 (hr)
DK (1) DK1631575T3 (hr)
ES (1) ES2274453T3 (hr)
HK (1) HK1092156A1 (hr)
HR (1) HRP20030381B1 (hr)
IS (1) IS8109A (hr)
PL (1) PL1631575T3 (hr)
PT (1) PT1631575E (hr)
RS (1) RS20050837A (hr)
SI (1) SI1631575T1 (hr)
WO (1) WO2004101591A1 (hr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846003A1 (en) * 2005-01-14 2007-10-24 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with anti-inflammatory activity
DE602006006546D1 (de) * 2005-01-14 2009-06-10 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
CA3130061C (en) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN104119413B (zh) * 2014-07-29 2016-08-24 华中农业大学 一种土拉霉素残留标示物的合成方法
CA2963815A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CA2980315A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
AU2019385333A1 (en) * 2018-11-19 2021-07-01 President And Fellows Of Harvard College C10-alkylene substituted 13-membered macrolides and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
HRP990130B1 (en) * 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
HRP20010146B1 (en) * 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
US6933283B2 (en) * 2002-04-25 2005-08-23 Abbott Laboratories 11-deoxy azalide antibacterials

Also Published As

Publication number Publication date
RS20050837A (en) 2007-12-31
PT1631575E (pt) 2007-01-31
JP2007501268A (ja) 2007-01-25
ES2274453T3 (es) 2007-05-16
CA2525143A1 (en) 2004-11-25
CL2004001026A1 (es) 2005-04-22
HRP20030381A2 (en) 2005-02-28
DK1631575T3 (da) 2007-02-26
DE602004003054T2 (de) 2007-06-06
ATE344270T1 (de) 2006-11-15
WO2004101591A1 (en) 2004-11-25
CY1107321T1 (el) 2012-11-21
DE602004003054D1 (de) 2006-12-14
AR044320A1 (es) 2005-09-07
SI1631575T1 (sl) 2007-04-30
CN1788013A (zh) 2006-06-14
CN100345860C (zh) 2007-10-31
US20070066544A1 (en) 2007-03-22
HK1092156A1 (en) 2007-02-02
EP1631575A1 (en) 2006-03-08
EP1631575B1 (en) 2006-11-02
IS8109A (is) 2005-10-31
PL1631575T3 (pl) 2007-03-30

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