HRP20030332A2 - Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors - Google Patents
Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors Download PDFInfo
- Publication number
- HRP20030332A2 HRP20030332A2 HR20030332A HRP20030332A HRP20030332A2 HR P20030332 A2 HRP20030332 A2 HR P20030332A2 HR 20030332 A HR20030332 A HR 20030332A HR P20030332 A HRP20030332 A HR P20030332A HR P20030332 A2 HRP20030332 A2 HR P20030332A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- pyridin
- group
- spiro
- triaza
- Prior art date
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- 239000003475 metalloproteinase inhibitor Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 222
- 125000000623 heterocyclic group Chemical group 0.000 claims description 101
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 86
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 80
- 239000001301 oxygen Substances 0.000 claims description 80
- 229910052760 oxygen Inorganic materials 0.000 claims description 80
- 125000006573 (C1-C10) heteroaryl group Chemical group 0.000 claims description 73
- 125000001424 substituent group Chemical group 0.000 claims description 56
- 229910052739 hydrogen Inorganic materials 0.000 claims description 51
- 239000001257 hydrogen Substances 0.000 claims description 51
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 43
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 39
- 208000035475 disorder Diseases 0.000 claims description 35
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 34
- 229910052717 sulfur Inorganic materials 0.000 claims description 34
- 239000011593 sulfur Substances 0.000 claims description 34
- 229910052799 carbon Inorganic materials 0.000 claims description 33
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 31
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 27
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
- 239000000460 chlorine Substances 0.000 claims description 24
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- 229910052731 fluorine Inorganic materials 0.000 claims description 24
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 23
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 23
- 229910052757 nitrogen Inorganic materials 0.000 claims description 23
- 229910052794 bromium Inorganic materials 0.000 claims description 22
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- COHKACKHFIJNRE-UHFFFAOYSA-N 1-[6-[4-(1,3,4-oxadiazol-2-yl)phenoxy]pyridin-3-yl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone Chemical compound C=1C=C(OC=2C=CC(=CC=2)C=2OC=NN=2)N=CC=1N1C(=O)CCC21C(=O)NC(=O)NC2=O COHKACKHFIJNRE-UHFFFAOYSA-N 0.000 claims description 5
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US24338900P | 2000-10-26 | 2000-10-26 | |
PCT/IB2001/001986 WO2002034753A2 (en) | 2000-10-26 | 2001-10-23 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
Publications (1)
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HRP20030332A2 true HRP20030332A2 (en) | 2003-06-30 |
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EP (1) | EP1332146A2 (xx) |
JP (1) | JP2004518635A (xx) |
KR (1) | KR20040004412A (xx) |
CN (1) | CN1501937A (xx) |
AP (1) | AP2001002318A0 (xx) |
AR (1) | AR035069A1 (xx) |
AU (1) | AU2002210813A1 (xx) |
BG (1) | BG107653A (xx) |
BR (1) | BR0114913A (xx) |
CA (1) | CA2425283A1 (xx) |
CZ (1) | CZ20031083A3 (xx) |
EA (1) | EA005762B1 (xx) |
EC (1) | ECSP034567A (xx) |
EE (1) | EE200300196A (xx) |
GT (1) | GT200100213A (xx) |
HN (1) | HN2001000244A (xx) |
HR (1) | HRP20030332A2 (xx) |
HU (1) | HUP0301577A3 (xx) |
IL (1) | IL154948A0 (xx) |
IS (1) | IS6762A (xx) |
MA (1) | MA26957A1 (xx) |
MX (1) | MXPA03003735A (xx) |
NO (1) | NO20031853L (xx) |
OA (1) | OA12529A (xx) |
PA (1) | PA8531401A1 (xx) |
PE (1) | PE20020589A1 (xx) |
PL (1) | PL366201A1 (xx) |
SK (1) | SK4972003A3 (xx) |
SV (1) | SV2003000705A (xx) |
TN (1) | TNSN01149A1 (xx) |
WO (1) | WO2002034753A2 (xx) |
ZA (1) | ZA200302190B (xx) |
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MXPA03005870A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
CA2433772C (en) | 2001-02-14 | 2008-10-07 | Warner-Lambert Company Llc | Pyrimidine matrix metalloproteinase inhibitors |
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
CA2462442A1 (en) | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkyne matrix metalloproteinase inhibitors |
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
WO2003091252A1 (en) * | 2002-04-25 | 2003-11-06 | Bristol-Myers Squibb Company | Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases |
WO2003091258A1 (en) * | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
CA2483075A1 (en) * | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors |
WO2004014908A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
WO2004014378A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
MXPA05001783A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz. |
WO2004014880A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Chromone derivatives as matrix metalloproteinase inhibitors |
PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
AU2003250470A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
EP1537098A1 (en) | 2002-08-13 | 2005-06-08 | Warner-Lambert Company LLC | Monocyclic derivatives as matrix metalloproteinase inhibitors |
AU2003253186A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
AU2003249531A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors |
WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
GB0223249D0 (en) * | 2002-10-08 | 2002-11-13 | Amersham Plc | Improved imaging agents |
WO2004084903A1 (en) * | 2003-03-27 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis |
WO2004084902A1 (en) * | 2003-03-28 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment of chronic wounds |
FR2858232B1 (fr) * | 2003-07-29 | 2006-03-03 | Pierre Potier | Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb |
DE602005008418D1 (de) * | 2004-04-01 | 2008-09-04 | Hoffmann La Roche | Verwendung von trioxopyrimidin zur behandlung und prävention von entzündlichen erkrankungen der bronchien |
DOP2006000268A (es) | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
CN102285934B (zh) * | 2009-01-08 | 2013-08-14 | 四川大学 | 螺环二烯酮衍生物及其制备方法和用途 |
PE20151295A1 (es) * | 2012-12-10 | 2015-10-10 | Chugai Pharmaceutical Co Ltd | Derivado de hidantoina |
KR101594506B1 (ko) * | 2014-03-20 | 2016-02-17 | 한국화학연구원 | 골 관련 질환 치료용 조성물 |
EP3153166B1 (en) | 2014-06-09 | 2022-08-03 | Chugai Seiyaku Kabushiki Kaisha | Hydantoin derivative-containing pharmaceutical composition |
US11292782B2 (en) | 2018-11-30 | 2022-04-05 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
CN110092790B (zh) * | 2019-06-11 | 2020-07-24 | 东北农业大学 | 一种生物碱类化合物及其制备方法和应用 |
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US3714093A (en) * | 1970-05-19 | 1973-01-30 | American Home Prod | Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones |
AU746853B2 (en) * | 1997-06-21 | 2002-05-02 | Roche Diagnostics Gmbh | Barbituric acid derivatives with antimetastatic and antitumor activity |
US6265578B1 (en) * | 1999-02-12 | 2001-07-24 | Hoffmann-La Roche Inc. | Pyrimidine-2,4,6-triones |
HN2000000137A (es) * | 1999-08-12 | 2001-02-02 | Pfizer Prod Inc | Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas |
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