HRP20030070A2 - Tartrate salts of thiazolidinedione derivative - Google Patents
Tartrate salts of thiazolidinedione derivative Download PDFInfo
- Publication number
- HRP20030070A2 HRP20030070A2 HR20030070A HRP20030070A HRP20030070A2 HR P20030070 A2 HRP20030070 A2 HR P20030070A2 HR 20030070 A HR20030070 A HR 20030070A HR P20030070 A HRP20030070 A HR P20030070A HR P20030070 A2 HRP20030070 A2 HR P20030070A2
- Authority
- HR
- Croatia
- Prior art keywords
- tartrate
- solvate
- methyl
- dione
- pyridyl
- Prior art date
Links
- 150000003892 tartrate salts Chemical class 0.000 title description 8
- 150000001467 thiazolidinediones Chemical class 0.000 title description 2
- FEWJPZIEWOKRBE-LWMBPPNESA-L D-tartrate(2-) Chemical class [O-]C(=O)[C@@H](O)[C@H](O)C([O-])=O FEWJPZIEWOKRBE-LWMBPPNESA-L 0.000 claims description 62
- 239000012453 solvate Substances 0.000 claims description 31
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 19
- 206010012601 diabetes mellitus Diseases 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 18
- 239000013543 active substance Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 13
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- 238000011282 treatment Methods 0.000 claims description 9
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- 239000003814 drug Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
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- 238000012916 structural analysis Methods 0.000 claims 2
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- 239000002904 solvent Substances 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
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- 238000002844 melting Methods 0.000 description 12
- 230000008018 melting Effects 0.000 description 12
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- AUONNNVJUCSETH-UHFFFAOYSA-N icosanoyl icosanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCC AUONNNVJUCSETH-UHFFFAOYSA-N 0.000 description 10
- 238000010992 reflux Methods 0.000 description 8
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- -1 salt ion Chemical class 0.000 description 7
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
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- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 1
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- 229920002472 Starch Polymers 0.000 description 1
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- 150000001298 alcohols Chemical class 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
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- 238000000449 magic angle spinning nuclear magnetic resonance spectrum Methods 0.000 description 1
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- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 239000001923 methylcellulose Substances 0.000 description 1
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- 201000009925 nephrosclerosis Diseases 0.000 description 1
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- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0019228.6A GB0019228D0 (en) | 2000-08-04 | 2000-08-04 | Novel pharmaceutical |
| PCT/GB2001/003515 WO2002012234A1 (en) | 2000-08-04 | 2001-08-03 | Tartrate salts of thiazolidinedione derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20030070A2 true HRP20030070A2 (en) | 2005-02-28 |
Family
ID=9897030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030070A HRP20030070A2 (en) | 2000-08-04 | 2003-02-03 | Tartrate salts of thiazolidinedione derivative |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US20040048899A1 (pl) |
| EP (1) | EP1305312B1 (pl) |
| JP (1) | JP2004505972A (pl) |
| KR (1) | KR100755173B1 (pl) |
| CN (1) | CN1458931A (pl) |
| AP (1) | AP1814A (pl) |
| AT (1) | ATE393153T1 (pl) |
| AU (1) | AU2001276509A1 (pl) |
| BG (1) | BG107606A (pl) |
| BR (1) | BR0112981A (pl) |
| CA (1) | CA2417829A1 (pl) |
| CZ (1) | CZ2003316A3 (pl) |
| DE (1) | DE60133746T2 (pl) |
| DK (1) | DK1305312T3 (pl) |
| DZ (1) | DZ3467A1 (pl) |
| EA (1) | EA004764B1 (pl) |
| EC (1) | ECSP034469A (pl) |
| ES (1) | ES2302506T3 (pl) |
| GB (1) | GB0019228D0 (pl) |
| HK (1) | HK1057359A1 (pl) |
| HR (1) | HRP20030070A2 (pl) |
| HU (1) | HUP0300777A3 (pl) |
| IL (2) | IL154278A0 (pl) |
| MA (1) | MA25898A1 (pl) |
| MX (1) | MXPA03001087A (pl) |
| NO (1) | NO324595B1 (pl) |
| NZ (1) | NZ524032A (pl) |
| OA (1) | OA12352A (pl) |
| PL (1) | PL360703A1 (pl) |
| PT (1) | PT1305312E (pl) |
| SI (1) | SI1305312T1 (pl) |
| SK (1) | SK1442003A3 (pl) |
| UA (1) | UA76721C2 (pl) |
| WO (1) | WO2002012234A1 (pl) |
| YU (1) | YU16303A (pl) |
| ZA (1) | ZA200300963B (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39384E1 (en) | 1993-09-01 | 2006-11-07 | Smithkline Beecham P.L.C. | Substituted thiazolidinedione derivatives |
| MY144177A (en) * | 2004-02-04 | 2011-08-15 | Novartis Ag | Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide. |
| BRPI0512245A (pt) * | 2004-06-30 | 2008-02-19 | Lilly Co Eli | composto, composição farmacêutica, e, uso do composto |
| US7435741B2 (en) * | 2006-05-09 | 2008-10-14 | Teva Pharmaceutical Industries, Ltd. | 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate |
| GB0616574D0 (en) * | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
| DE102009053562A1 (de) | 2009-11-18 | 2011-05-19 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Rosiglitazonsuccinat enthaltende pharmazeutische Zusammensetzung |
| CN102532122B (zh) * | 2010-12-29 | 2015-12-02 | 开封制药(集团)有限公司 | 酒石酸罗格列酮的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE186724T1 (de) * | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
| US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
| US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
-
2000
- 2000-08-04 GB GBGB0019228.6A patent/GB0019228D0/en not_active Ceased
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2001
- 2001-03-08 UA UA2003020940A patent/UA76721C2/uk unknown
- 2001-08-03 OA OA1200300026A patent/OA12352A/en unknown
- 2001-08-03 SK SK144-2003A patent/SK1442003A3/sk unknown
- 2001-08-03 WO PCT/GB2001/003515 patent/WO2002012234A1/en active IP Right Grant
- 2001-08-03 PT PT01954162T patent/PT1305312E/pt unknown
- 2001-08-03 IL IL15427801A patent/IL154278A0/xx active IP Right Grant
- 2001-08-03 EA EA200300234A patent/EA004764B1/ru not_active IP Right Cessation
- 2001-08-03 DK DK01954162T patent/DK1305312T3/da active
- 2001-08-03 BR BR0112981-3A patent/BR0112981A/pt not_active IP Right Cessation
- 2001-08-03 HU HU0300777A patent/HUP0300777A3/hu unknown
- 2001-08-03 KR KR1020037001606A patent/KR100755173B1/ko not_active IP Right Cessation
- 2001-08-03 DZ DZ013467A patent/DZ3467A1/fr active
- 2001-08-03 AP APAP/P/2003/002738A patent/AP1814A/en active
- 2001-08-03 ES ES01954162T patent/ES2302506T3/es not_active Expired - Lifetime
- 2001-08-03 MX MXPA03001087A patent/MXPA03001087A/es active IP Right Grant
- 2001-08-03 NZ NZ524032A patent/NZ524032A/en unknown
- 2001-08-03 JP JP2002518209A patent/JP2004505972A/ja not_active Withdrawn
- 2001-08-03 US US10/343,866 patent/US20040048899A1/en not_active Abandoned
- 2001-08-03 PL PL36070301A patent/PL360703A1/pl not_active Application Discontinuation
- 2001-08-03 CZ CZ2003316A patent/CZ2003316A3/cs unknown
- 2001-08-03 YU YU16303A patent/YU16303A/sh unknown
- 2001-08-03 CN CN01815685A patent/CN1458931A/zh active Pending
- 2001-08-03 CA CA002417829A patent/CA2417829A1/en not_active Abandoned
- 2001-08-03 SI SI200130830T patent/SI1305312T1/sl unknown
- 2001-08-03 AU AU2001276509A patent/AU2001276509A1/en not_active Abandoned
- 2001-08-03 AT AT01954162T patent/ATE393153T1/de not_active IP Right Cessation
- 2001-08-03 DE DE60133746T patent/DE60133746T2/de not_active Expired - Fee Related
- 2001-08-03 EP EP01954162A patent/EP1305312B1/en not_active Expired - Lifetime
-
2003
- 2003-01-31 NO NO20030507A patent/NO324595B1/no not_active IP Right Cessation
- 2003-02-03 MA MA27021A patent/MA25898A1/fr unknown
- 2003-02-03 HR HR20030070A patent/HRP20030070A2/hr not_active Application Discontinuation
- 2003-02-03 IL IL154278A patent/IL154278A/en not_active IP Right Cessation
- 2003-02-04 EC EC2003004469A patent/ECSP034469A/es unknown
- 2003-02-28 BG BG107606A patent/BG107606A/bg unknown
- 2003-03-04 ZA ZA200300963A patent/ZA200300963B/en unknown
- 2003-10-24 HK HK03107710.1A patent/HK1057359A1/xx not_active IP Right Cessation
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