HRP20020687B1 - DERIVATI 8,8a-DIHIDRO-INDENO[1,2-d]TIAZOLA KOJI U POLOZAJU 2 NOSE SUPSTITUENTE SA SULFONAMIDNOM ILI SULFONSKOM STRUKTUROM, POSTUPAK ZA NJIHOVU PROIZVODNJU I NJIHOVA UPOTREBA KAO LIJEKA - Google Patents

DERIVATI 8,8a-DIHIDRO-INDENO[1,2-d]TIAZOLA KOJI U POLOZAJU 2 NOSE SUPSTITUENTE SA SULFONAMIDNOM ILI SULFONSKOM STRUKTUROM, POSTUPAK ZA NJIHOVU PROIZVODNJU I NJIHOVA UPOTREBA KAO LIJEKA

Info

Publication number
HRP20020687B1
HRP20020687B1 HR20020687A HRP20020687A HRP20020687B1 HR P20020687 B1 HRP20020687 B1 HR P20020687B1 HR 20020687 A HR20020687 A HR 20020687A HR P20020687 A HRP20020687 A HR P20020687A HR P20020687 B1 HRP20020687 B1 HR P20020687B1
Authority
HR
Croatia
Prior art keywords
alkyl
phenyl
pyridyl
thienyl
substituted
Prior art date
Application number
HR20020687A
Other languages
English (en)
Croatian (hr)
Inventor
Jaehne Gerhard
Lang Hans-Jochen
Gossel Matthias
Bickel Martin
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of HRP20020687A2 publication Critical patent/HRP20020687A2/hr
Publication of HRP20020687B1 publication Critical patent/HRP20020687B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
HR20020687A 2000-02-26 2001-02-13 DERIVATI 8,8a-DIHIDRO-INDENO[1,2-d]TIAZOLA KOJI U POLOZAJU 2 NOSE SUPSTITUENTE SA SULFONAMIDNOM ILI SULFONSKOM STRUKTUROM, POSTUPAK ZA NJIHOVU PROIZVODNJU I NJIHOVA UPOTREBA KAO LIJEKA HRP20020687B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10009311 2000-02-26
PCT/EP2001/001553 WO2001062747A1 (de) 2000-02-26 2001-02-13 8,8a-dihydro-indeno[1,2-d]thiazol-derivate, die in 2-stellung einen substituenten mit einer sulfonamidstruktur oder sulfonstruktur tragen; verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
HRP20020687A2 HRP20020687A2 (en) 2004-12-31
HRP20020687B1 true HRP20020687B1 (hr) 2011-01-31

Family

ID=7632679

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020687A HRP20020687B1 (hr) 2000-02-26 2001-02-13 DERIVATI 8,8a-DIHIDRO-INDENO[1,2-d]TIAZOLA KOJI U POLOZAJU 2 NOSE SUPSTITUENTE SA SULFONAMIDNOM ILI SULFONSKOM STRUKTUROM, POSTUPAK ZA NJIHOVU PROIZVODNJU I NJIHOVA UPOTREBA KAO LIJEKA

Country Status (29)

Country Link
US (2) US6352987B2 (cs)
EP (1) EP1261593B1 (cs)
JP (1) JP4950405B2 (cs)
KR (1) KR100763214B1 (cs)
CN (1) CN1173959C (cs)
AT (1) ATE248155T1 (cs)
AU (2) AU4413601A (cs)
BR (1) BR0108631A (cs)
CA (1) CA2400704C (cs)
CZ (1) CZ301253B6 (cs)
DE (1) DE50100558D1 (cs)
DK (1) DK1261593T3 (cs)
EE (1) EE04963B1 (cs)
ES (1) ES2206412T3 (cs)
HK (1) HK1052515B (cs)
HR (1) HRP20020687B1 (cs)
HU (1) HU229137B1 (cs)
IL (1) IL151460A (cs)
MX (1) MXPA02007025A (cs)
NO (1) NO323400B1 (cs)
NZ (1) NZ520981A (cs)
PL (1) PL202763B1 (cs)
PT (1) PT1261593E (cs)
RS (1) RS49933B (cs)
RU (1) RU2263113C2 (cs)
SI (1) SI1261593T1 (cs)
SK (1) SK285571B6 (cs)
WO (1) WO2001062747A1 (cs)
ZA (1) ZA200206580B (cs)

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US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7261482B2 (en) * 2004-01-21 2007-08-28 Silverbrook Research Pty Ltd Photofinishing system with slitting mechanism
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201690035A1 (ru) 2011-02-25 2016-05-31 Мерк Шарп Энд Домэ Корп. Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов
EP2681236B1 (en) 2011-03-01 2018-01-03 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
JP2015525782A (ja) 2012-08-02 2015-09-07 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病性三環式化合物
WO2014130608A1 (en) 2013-02-22 2014-08-28 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174397A (en) * 1976-09-08 1979-11-13 Hoechst Aktiengesellschaft Thiazolidine derivatives
WO2000051997A1 (de) * 1999-02-26 2000-09-08 Aventis Pharma Deutschland Gmbh Polycyclische thiazol-systeme und ihre verwendung als anorektika

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CZ2001170A3 (cs) * 1999-07-03 2001-06-13 Aventis Pharma Gmbh Polycyklické thiazolidin-2-ylidenaminy, způsob jejich přípravy a léčivo, které je obsahuje
CZ20011111A3 (cs) * 1999-09-16 2001-07-11 Aventis Pharma Deutschland Gmbh Deriváty indeno-, nafto- a benzocyklohepťadihydrothiazolu, jejich příprava a použití jako anorektická léčiva

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174397A (en) * 1976-09-08 1979-11-13 Hoechst Aktiengesellschaft Thiazolidine derivatives
WO2000051997A1 (de) * 1999-02-26 2000-09-08 Aventis Pharma Deutschland Gmbh Polycyclische thiazol-systeme und ihre verwendung als anorektika

Also Published As

Publication number Publication date
CA2400704A1 (en) 2001-08-30
RU2263113C2 (ru) 2005-10-27
PT1261593E (pt) 2004-01-30
CZ20022861A3 (cs) 2002-11-13
MXPA02007025A (es) 2003-03-27
HUP0300304A2 (hu) 2003-06-28
NO323400B1 (no) 2007-04-23
HUP0300304A3 (en) 2004-10-28
SI1261593T1 (en) 2004-02-29
AU4413601A (en) 2001-09-03
NZ520981A (en) 2004-08-27
HRP20020687A2 (en) 2004-12-31
ES2206412T3 (es) 2004-05-16
RU2002125673A (ru) 2004-01-10
ATE248155T1 (de) 2003-09-15
US6444669B1 (en) 2002-09-03
JP2003531117A (ja) 2003-10-21
PL357195A1 (en) 2004-07-26
CA2400704C (en) 2008-11-04
US6352987B2 (en) 2002-03-05
NO20023977D0 (no) 2002-08-21
SK12252002A3 (sk) 2003-03-04
BR0108631A (pt) 2002-12-03
EP1261593B1 (de) 2003-08-27
IL151460A (en) 2008-08-07
US20010039278A1 (en) 2001-11-08
CZ301253B6 (cs) 2009-12-23
ZA200206580B (en) 2003-05-15
WO2001062747A1 (de) 2001-08-30
DE50100558D1 (de) 2003-10-02
HK1052515B (zh) 2005-04-22
JP4950405B2 (ja) 2012-06-13
EE04963B1 (et) 2008-02-15
AU2001244136B2 (en) 2005-04-14
KR20020079897A (ko) 2002-10-19
DK1261593T3 (da) 2003-12-01
EP1261593A1 (de) 2002-12-04
CN1406234A (zh) 2003-03-26
HU229137B1 (en) 2013-08-28
PL202763B1 (pl) 2009-07-31
RS49933B (sr) 2008-09-29
EE200200467A (et) 2003-12-15
KR100763214B1 (ko) 2007-10-08
YU56402A (sh) 2005-11-28
NO20023977L (no) 2002-10-18
HK1052515A1 (en) 2003-09-19
SK285571B6 (sk) 2007-04-05
CN1173959C (zh) 2004-11-03
US20020103231A1 (en) 2002-08-01

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20140103

Year of fee payment: 14

PBON Lapse due to non-payment of renewal fee

Effective date: 20150213