EE04963B1 - 8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena - Google Patents
8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitenaInfo
- Publication number
- EE04963B1 EE04963B1 EEP200200467A EEP200200467A EE04963B1 EE 04963 B1 EE04963 B1 EE 04963B1 EE P200200467 A EEP200200467 A EE P200200467A EE P200200467 A EEP200200467 A EE P200200467A EE 04963 B1 EE04963 B1 EE 04963B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- substituent
- sulphonorma
- droindeno
- sulphonamido
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- -1 sulphonamido Chemical group 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- DZMMSRPZFITCLI-UHFFFAOYSA-N 3a,4-dihydro-2h-indeno[1,2-d][1,3]thiazole Chemical class C1=CC=C2C3=NCSC3CC2=C1 DZMMSRPZFITCLI-UHFFFAOYSA-N 0.000 abstract 1
- 230000001539 anorectic effect Effects 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10009311 | 2000-02-26 | ||
| PCT/EP2001/001553 WO2001062747A1 (de) | 2000-02-26 | 2001-02-13 | 8,8a-dihydro-indeno[1,2-d]thiazol-derivate, die in 2-stellung einen substituenten mit einer sulfonamidstruktur oder sulfonstruktur tragen; verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200200467A EE200200467A (et) | 2003-12-15 |
| EE04963B1 true EE04963B1 (et) | 2008-02-15 |
Family
ID=7632679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200200467A EE04963B1 (et) | 2000-02-26 | 2001-02-13 | 8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6352987B2 (cs) |
| EP (1) | EP1261593B1 (cs) |
| JP (1) | JP4950405B2 (cs) |
| KR (1) | KR100763214B1 (cs) |
| CN (1) | CN1173959C (cs) |
| AT (1) | ATE248155T1 (cs) |
| AU (2) | AU4413601A (cs) |
| BR (1) | BR0108631A (cs) |
| CA (1) | CA2400704C (cs) |
| CZ (1) | CZ301253B6 (cs) |
| DE (1) | DE50100558D1 (cs) |
| DK (1) | DK1261593T3 (cs) |
| EE (1) | EE04963B1 (cs) |
| ES (1) | ES2206412T3 (cs) |
| HK (1) | HK1052515B (cs) |
| HR (1) | HRP20020687B1 (cs) |
| HU (1) | HU229137B1 (cs) |
| IL (1) | IL151460A (cs) |
| MX (1) | MXPA02007025A (cs) |
| NO (1) | NO323400B1 (cs) |
| NZ (1) | NZ520981A (cs) |
| PL (1) | PL202763B1 (cs) |
| PT (1) | PT1261593E (cs) |
| RS (1) | RS49933B (cs) |
| RU (1) | RU2263113C2 (cs) |
| SI (1) | SI1261593T1 (cs) |
| SK (1) | SK285571B6 (cs) |
| WO (1) | WO2001062747A1 (cs) |
| ZA (1) | ZA200206580B (cs) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7261482B2 (en) * | 2004-01-21 | 2007-08-28 | Silverbrook Research Pty Ltd | Photofinishing system with slitting mechanism |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| MX2011004258A (es) | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| ES2652662T3 (es) | 2011-02-25 | 2018-02-05 | Merck Sharp & Dohme Corp. | Novedosos derivados de azabencimidazol cíclicos útiles como agentes antidiabéticos |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| AU2013296470B2 (en) | 2012-08-02 | 2016-03-17 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| CA2898482A1 (en) | 2013-02-22 | 2014-08-28 | Linda L. Brockunier | Antidiabetic bicyclic compounds |
| US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507868A (en) * | 1968-10-21 | 1970-04-21 | Sandoz Ag | Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| CA1292226C (en) * | 1986-01-16 | 1991-11-19 | Terumi Hachiya | Indenothiazole derivative and process for preparing the same |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19844547C2 (de) * | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908533A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| CZ2001170A3 (cs) * | 1999-07-03 | 2001-06-13 | Aventis Pharma Gmbh | Polycyklické thiazolidin-2-ylidenaminy, způsob jejich přípravy a léčivo, které je obsahuje |
| CZ20011111A3 (cs) * | 1999-09-16 | 2001-07-11 | Aventis Pharma Deutschland Gmbh | Deriváty indeno-, nafto- a benzocyklohepťadihydrothiazolu, jejich příprava a použití jako anorektická léčiva |
-
2001
- 2001-02-13 CN CNB018055877A patent/CN1173959C/zh not_active Expired - Fee Related
- 2001-02-13 KR KR1020027011035A patent/KR100763214B1/ko not_active Expired - Fee Related
- 2001-02-13 AU AU4413601A patent/AU4413601A/xx active Pending
- 2001-02-13 EE EEP200200467A patent/EE04963B1/xx not_active IP Right Cessation
- 2001-02-13 HU HU0300304A patent/HU229137B1/hu not_active IP Right Cessation
- 2001-02-13 DK DK01916989T patent/DK1261593T3/da active
- 2001-02-13 WO PCT/EP2001/001553 patent/WO2001062747A1/de active IP Right Grant
- 2001-02-13 HR HR20020687A patent/HRP20020687B1/xx not_active IP Right Cessation
- 2001-02-13 PL PL357195A patent/PL202763B1/pl unknown
- 2001-02-13 AU AU2001244136A patent/AU2001244136B2/en not_active Ceased
- 2001-02-13 CA CA002400704A patent/CA2400704C/en not_active Expired - Fee Related
- 2001-02-13 RU RU2002125673/04A patent/RU2263113C2/ru active
- 2001-02-13 CZ CZ20022861A patent/CZ301253B6/cs not_active IP Right Cessation
- 2001-02-13 NZ NZ520981A patent/NZ520981A/en not_active IP Right Cessation
- 2001-02-13 SK SK1225-2002A patent/SK285571B6/sk not_active IP Right Cessation
- 2001-02-13 RS YUP-564/02A patent/RS49933B/sr unknown
- 2001-02-13 MX MXPA02007025A patent/MXPA02007025A/es active IP Right Grant
- 2001-02-13 DE DE50100558T patent/DE50100558D1/de not_active Expired - Lifetime
- 2001-02-13 ES ES01916989T patent/ES2206412T3/es not_active Expired - Lifetime
- 2001-02-13 EP EP01916989A patent/EP1261593B1/de not_active Expired - Lifetime
- 2001-02-13 BR BR0108631-6A patent/BR0108631A/pt not_active Application Discontinuation
- 2001-02-13 SI SI200130038T patent/SI1261593T1/xx unknown
- 2001-02-13 PT PT01916989T patent/PT1261593E/pt unknown
- 2001-02-13 AT AT01916989T patent/ATE248155T1/de active
- 2001-02-13 HK HK03104913.3A patent/HK1052515B/zh not_active IP Right Cessation
- 2001-02-13 JP JP2001562529A patent/JP4950405B2/ja not_active Expired - Fee Related
- 2001-02-26 US US09/792,049 patent/US6352987B2/en not_active Expired - Lifetime
-
2002
- 2002-01-17 US US10/046,989 patent/US6444669B1/en not_active Expired - Lifetime
- 2002-08-16 ZA ZA200206580A patent/ZA200206580B/en unknown
- 2002-08-21 NO NO20023977A patent/NO323400B1/no not_active IP Right Cessation
- 2002-08-25 IL IL151460A patent/IL151460A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE04963B1 (et) | 8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena | |
| NO20023978L (no) | 8,8A-dihydro-indeno(1,2-D)tiazolderivater, substituert i posisjon 8A, en fremgangsmåte for deres fremstilling og deresanvendelse som legemidler, for eksempel anoreksimidler | |
| PT1140944E (pt) | Derivados de epotilona e sua utilizacao como agentes antitumorais | |
| BRPI0407387A (pt) | Derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona substituìdos por nitrogênio, processos para a sua preparação e sua aplicação com medicamento | |
| BR0312513A (pt) | Derivados de glicosìdeo de tiofeno, processos para a produção dos mesmos, medicamentos que contêm esses compostos e uso dos mesmos | |
| BR0207278A (pt) | Derivados de ftalazinona-piperidina como inibidores de pde4 | |
| BR0107770A (pt) | Derivados de 3-fenóxi-1-fenil acetileno e seu uso como herbicidas | |
| BR0210746A (pt) | Derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral | |
| BR9805437A (pt) | Derivados de benzocicloalquenos heterocìclicos, processo para fabricação de derivados de benzocicloalquenos heterocìclicos e uso de derivados de benzocicloalquenos heterocìclicos. | |
| PT1183247E (pt) | Sistemas tiazole policiclicos e sua utilizacao como anorecticos | |
| MXPA04001855A (es) | Derivados de sistemas de indan-1-ol c2-sustituidos, metodos para la produccion de los mismos y su uso como medicamentos. | |
| BR0012329A (pt) | Derivados de benzofurano | |
| GEP20063758B (en) | Benzothia(Dia)Zine Derivatives and Method for Their Use as AMPA Modulators | |
| ATE261938T1 (de) | Benzolsulfonamid-derivate und ihre verwendung | |
| TR200100475T2 (tr) | N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları. | |
| EE200200465A (et) | Asendatud 8,8a-dihüdro-3aH-indeno[1,2-d]tiasoolid, nende valmistamismeetod ja kasutamine ravimitena | |
| UY26347A1 (es) | Derivados de bencimidazol sustituidos con arilsulfonamida, procedimiento para su preparación y su empleo como medicamentos. | |
| DK1220844T3 (da) | Arylsulfonamid-substituerede benzimidazolderivater og deres anvendelse som tryptase-inhibitorer | |
| UY26346A1 (es) | Derivados de bencimidazol sustituidos, procedimiento para preparación y su empleo como medicamentos. | |
| UY26979A1 (es) | Nuevos derivados de piranosido | |
| DOP2002000362A (es) | Nuevas arilsulfonamidas como agentes antivirales. | |
| NO20012328L (no) | Fluorerte 3,4-dihydrokinolinderivater anvendt som NOS- inhibitorer | |
| ECSP982773A (es) | Derivados heterociclicos de benzocicloalqueno y procedimiento para su fabricacion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20150213 |