HRP20020518B1 - Substituted homopiperidinyl benzimidazole analogues as fundic relaxants - Google Patents

Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Info

Publication number
HRP20020518B1
HRP20020518B1 HR20020518A HRP20020518A HRP20020518B1 HR P20020518 B1 HRP20020518 B1 HR P20020518B1 HR 20020518 A HR20020518 A HR 20020518A HR P20020518 A HRP20020518 A HR P20020518A HR P20020518 B1 HRP20020518 B1 HR P20020518B1
Authority
HR
Croatia
Prior art keywords
alkyl
hydroxy
amino
substituted
alkyloxy
Prior art date
Application number
HR20020518A
Other languages
English (en)
Croatian (hr)
Inventor
Eduard Janssens Frans
Emile Jerome
Maria Sommen Francois
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20020518A2 publication Critical patent/HRP20020518A2/hr
Publication of HRP20020518B1 publication Critical patent/HRP20020518B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
HR20020518A 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants HRP20020518B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204441 1999-12-21
PCT/EP2000/012858 WO2001046189A1 (en) 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Publications (2)

Publication Number Publication Date
HRP20020518A2 HRP20020518A2 (en) 2004-08-31
HRP20020518B1 true HRP20020518B1 (en) 2009-02-28

Family

ID=8241040

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020518A HRP20020518B1 (en) 1999-12-21 2000-12-14 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Country Status (33)

Country Link
US (1) US7304052B2 (cs)
EP (1) EP1250337B1 (cs)
JP (1) JP4852210B2 (cs)
KR (1) KR100715351B1 (cs)
CN (1) CN100343251C (cs)
AT (1) ATE416174T1 (cs)
AU (1) AU781144B2 (cs)
BG (1) BG65784B1 (cs)
BR (1) BRPI0016638B8 (cs)
CA (1) CA2393158C (cs)
CY (1) CY1108844T1 (cs)
CZ (1) CZ299803B6 (cs)
DE (1) DE60041001D1 (cs)
DK (1) DK1250337T3 (cs)
EA (1) EA005851B1 (cs)
EE (1) EE05182B1 (cs)
ES (1) ES2317856T3 (cs)
HK (1) HK1053109B (cs)
HR (1) HRP20020518B1 (cs)
HU (1) HU229929B1 (cs)
IL (2) IL150310A0 (cs)
MX (1) MXPA02006346A (cs)
MY (1) MY127758A (cs)
NO (1) NO322362B1 (cs)
NZ (1) NZ518816A (cs)
PL (1) PL199678B1 (cs)
PT (1) PT1250337E (cs)
SI (1) SI1250337T1 (cs)
SK (1) SK287113B6 (cs)
TW (1) TWI225488B (cs)
UA (1) UA73963C2 (cs)
WO (1) WO2001046189A1 (cs)
ZA (1) ZA200204983B (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JP2005532991A (ja) 2002-01-10 2005-11-04 ニューロジェン・コーポレーション メラニン凝集ホルモン受容体リガンド：置換２−（４−ベンジル−ピペラジン−１−イルメチル）−及び２−（４−ベンジル−ジアゼパン−１−イルメチル）−１ｈ−ベンゾイミダゾールアナログ
AU2005214225B2 (en) * 2004-02-19 2010-05-20 Banyu Pharmaceutical Co., Ltd. Novel sulfone amide derivative
UA101149C2 (en) 2007-01-25 2013-03-11 Янссен Фармацевтика Нв 2-piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives
CN102958933B (zh) 2010-06-24 2016-02-03 吉里德科学公司 作为抗病毒药的吡唑并[1,5-a]嘧啶类
US20130303782A1 (en) * 2010-11-24 2013-11-14 Sequent Scientific Limited Process for preparation of albendazole
JP2014159375A (ja) * 2011-06-15 2014-09-04 Takeda Chem Ind Ltd アゼパン化合物
PT2794611T (pt) 2011-12-22 2017-12-06 Gilead Sciences Inc Pirazolo[1,5-a]pirimidinas como agentes antivirais
KR102181318B1 (ko) 2012-04-17 2020-11-20 길리애드 사이언시즈, 인코포레이티드 항바이러스 치료를 위한 화합물 및 방법
WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors
PL3720855T3 (pl) * 2017-12-08 2022-01-24 Boehringer Ingelheim International Gmbh Pochodne imidazopirydyny i ich zastosowanie jako leku

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197A1 (de) * 1970-12-08 1972-06-15 Bayer Ag Verfahren zur Herstellung von 2-Aminobenzthiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) * 1981-11-06 1983-05-25 Kanebo, Ltd. Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0580541A1 (en) * 1992-07-20 1994-01-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101067A1 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
FR2528526A1 (fr) * 1982-06-09 1983-12-16 Sfr Sa Robinetterie Butee se fixant dans un alesage d'un dispositif
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3634066A1 (de) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
JPH0260197A (ja) * 1988-08-26 1990-02-28 Nec Corp パッケージ構造
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
PL307026A1 (en) * 1992-07-08 1995-05-02 Monsanto Co Method of producing ppaliative effect in respect to swine gastric ulcers
EP0711768B1 (en) * 1994-05-31 2002-02-13 Mitsui Chemicals, Inc. Benzimidazole derivative
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
TWI225488B (en) 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060197A1 (de) * 1970-12-08 1972-06-15 Bayer Ag Verfahren zur Herstellung von 2-Aminobenzthiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) * 1981-11-06 1983-05-25 Kanebo, Ltd. Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0580541A1 (en) * 1992-07-20 1994-01-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents

Also Published As

Publication number Publication date
UA73963C2 (uk) 2005-10-17
ATE416174T1 (de) 2008-12-15
CN1411460A (zh) 2003-04-16
EA200200700A1 (ru) 2003-06-26
CA2393158A1 (en) 2001-06-28
BR0016638B1 (pt) 2013-02-05
BG106749A (en) 2003-01-31
US20030139393A1 (en) 2003-07-24
US7304052B2 (en) 2007-12-04
MY127758A (en) 2006-12-29
NO322362B1 (no) 2006-09-25
WO2001046189A1 (en) 2001-06-28
MXPA02006346A (es) 2002-12-13
KR20020062643A (ko) 2002-07-26
BR0016638A (pt) 2002-10-01
SK287113B6 (sk) 2009-12-07
PT1250337E (pt) 2009-03-05
CZ20022055A3 (cs) 2003-06-18
EA005851B1 (ru) 2005-06-30
NO20022977D0 (no) 2002-06-20
ES2317856T3 (es) 2009-05-01
IL150310A0 (en) 2002-12-01
HRP20020518A2 (en) 2004-08-31
IL150310A (en) 2008-07-08
SI1250337T1 (sl) 2009-04-30
EE05182B1 (et) 2009-06-15
TWI225488B (en) 2004-12-21
HU229929B1 (en) 2015-01-28
NO20022977L (no) 2002-08-08
CY1108844T1 (el) 2014-07-02
CN100343251C (zh) 2007-10-17
BRPI0016638B8 (pt) 2017-04-25
JP4852210B2 (ja) 2012-01-11
AU781144B2 (en) 2005-05-05
KR100715351B1 (ko) 2007-05-08
NZ518816A (en) 2003-01-31
PL199678B1 (pl) 2008-10-31
JP2003518118A (ja) 2003-06-03
HUP0203847A2 (hu) 2003-03-28
HK1053109A1 (zh) 2003-10-10
HK1053109B (zh) 2008-08-01
CA2393158C (en) 2010-10-19
CZ299803B6 (cs) 2008-12-03
EP1250337B1 (en) 2008-12-03
SK8542002A3 (en) 2003-07-01
DE60041001D1 (de) 2009-01-15
DK1250337T3 (da) 2009-03-30
EE200200326A (et) 2003-10-15
EP1250337A1 (en) 2002-10-23
PL355442A1 (en) 2004-04-19
ZA200204983B (en) 2003-09-22
AU2167301A (en) 2001-07-03
HUP0203847A3 (en) 2004-07-28
BG65784B1 (bg) 2009-11-30

Similar Documents

Publication Publication Date Title
HRP20020518B1 (en) Substituted homopiperidinyl benzimidazole analogues as fundic relaxants
MEP10709A (en) 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
AR035991A1 (es) Derivados de benzimidazoles e imidazopiridinas, un procedimiento para su preparacion, composiciones farmaceuticas, un procedimiento para su preparacion, y un medicamento utiles como inhibidores de la replicacion del virus sincitial respiratorio
HRP20080064T5 (en) Prodrugs of piperazine and substituted piperidine antiviral agents
NO2015020I2 (no) Ceritinib eller et farmasøytisk akseptabelt salt derav
HRP20120351T1 (hr) Macrociklički derivati kinazolina kao antiproliferativna sredstva
EA200601177A1 (ru) Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов
ES2322602T3 (es) Compuestos heterotetraciclicos condensados y su uso como inhibidor de polimerasa del vhc.
AR056327A1 (es) Compuestos de nucleosidos para el tratamiento de infecciones virales
NO20061416L (no) Pyrimidotiofenforbindelser
AR057894A1 (es) Derivados de tiofeno
NO20013379D0 (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
AR047817A1 (es) Derivados de aril- y heteroarilpiperidincarboxilatos, su preparacion y su aplicacion en terapeutica
AR041250A1 (es) Derivados de sulfonamida como inhibidores de enzimas convertidoras de tnf-alfa
MX2010003950A (es) Derivado de amina que tiene actividad antagonista del receptor y5 de neuropeptido y (npy) y uso del mismo.
EA201101297A1 (ru) Аддитивные соли аминов, содержащих гидроксильные и/или карбоксильные группы, с производными аминоникотиновой кислоты в качестве ингибиторов dhodh
EA200100018A1 (ru) Гербицидная смесь, содержащая замещенное 3-гетероциклилом производное бензоила, азотосодержащее удобрение и вспомогательный агент
EP0640080A1 (en) SUBSTITUTED INDOLE AND AZAINDOLE AS ANGIOTENSIN II ANTAGONISTS.
MEP24208A (en) Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
MX389276B (es) Compuesto novedoso y sal de este aceptable desde el punto de vista farmacologico.
HRP20010453B1 (hr) Antihistaminski spiro spojevi
MX2024008480A (es) Compuesto heterociclico que contiene nitrogeno que tiene un efecto de activacion del factor 2 relacionado con el factor nuclear eritroide 2 (nrf2).
SE7706346L (sv) Bensaminderivat
YU178391A (sh) Jedinjenja 7-acil-3(supstituisanih karbamoiloksi) cefema i postupak za njihovo dobijanje
HRP20080097T5 (en) Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20171110

Year of fee payment: 18

PBON Lapse due to non-payment of renewal fee

Effective date: 20181214