HRP20020142B1 - Postupak za pripravljanje n-(1,1-dimetiletil)-4-[[5'-etoksi-4-cis-[2-(4-morfolino)etoksi]-2'-oksospiro[cikloheksan-1,3'-[h]indol]-1'(2'h)-il]-sulfonil]-3-metoksibenzamida i njegovih soli - Google Patents
Postupak za pripravljanje n-(1,1-dimetiletil)-4-[[5'-etoksi-4-cis-[2-(4-morfolino)etoksi]-2'-oksospiro[cikloheksan-1,3'-[h]indol]-1'(2'h)-il]-sulfonil]-3-metoksibenzamida i njegovih soliInfo
- Publication number
- HRP20020142B1 HRP20020142B1 HR20020142A HRP20020142A HRP20020142B1 HR P20020142 B1 HRP20020142 B1 HR P20020142B1 HR 20020142 A HR20020142 A HR 20020142A HR P20020142 A HRP20020142 A HR P20020142A HR P20020142 B1 HRP20020142 B1 HR P20020142B1
- Authority
- HR
- Croatia
- Prior art keywords
- ethoxy
- salts
- cyklohexan
- morfolino
- oxospiro
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Abstract
Postupak za pripravljanje spoja formule I i njegovih soli reakcijom spoja formule II sa spojem formule III, naznačen time, da obuhvaća izvođenje reakcije u dimetil sulfoksidu, na temperaturi između 10°C i 40°C, najbolje na sobnoj temperaturi te transformiranje u rezultirajuću bazu formule I, po želji, u njezinu sol ranije poznatim postupcima.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9902376A HUP9902376A3 (en) | 1999-07-15 | 1999-07-15 | Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts |
PCT/HU2000/000078 WO2001005791A2 (en) | 1999-07-15 | 2000-07-13 | NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20020142A2 HRP20020142A2 (en) | 2003-12-31 |
HRP20020142B1 true HRP20020142B1 (hr) | 2010-09-30 |
Family
ID=89998742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20020142A HRP20020142B1 (hr) | 1999-07-15 | 2002-02-14 | Postupak za pripravljanje n-(1,1-dimetiletil)-4-[[5'-etoksi-4-cis-[2-(4-morfolino)etoksi]-2'-oksospiro[cikloheksan-1,3'-[h]indol]-1'(2'h)-il]-sulfonil]-3-metoksibenzamida i njegovih soli |
Country Status (17)
Country | Link |
---|---|
US (1) | US6600039B1 (hr) |
EP (1) | EP1196381B1 (hr) |
JP (1) | JP2003505389A (hr) |
CN (1) | CN1174969C (hr) |
AT (1) | ATE264842T1 (hr) |
AU (1) | AU6308100A (hr) |
BR (1) | BR0012425A (hr) |
CA (1) | CA2378087C (hr) |
CZ (1) | CZ2002145A3 (hr) |
DE (1) | DE60010083T2 (hr) |
ES (1) | ES2216927T3 (hr) |
HR (1) | HRP20020142B1 (hr) |
HU (1) | HUP9902376A3 (hr) |
MX (1) | MXPA01013344A (hr) |
PL (1) | PL195787B1 (hr) |
SK (1) | SK285818B6 (hr) |
WO (1) | WO2001005791A2 (hr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4823614A (en) * | 1986-04-28 | 1989-04-25 | Dahlin Erik B | Coriolis-type mass flowmeter |
DE60204154T2 (de) * | 2001-07-31 | 2006-01-19 | Sanofi-Aventis | Verfahren zur herstellung von 3 spiro'cyclohexan-1,3'-'3h!indolin-2'-on!derivaten |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997015556A1 (fr) * | 1995-10-24 | 1997-05-01 | Sanofi | Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
1999
- 1999-07-15 HU HU9902376A patent/HUP9902376A3/hu unknown
-
2000
- 2000-07-13 CA CA002378087A patent/CA2378087C/en not_active Expired - Fee Related
- 2000-07-13 EP EP00949822A patent/EP1196381B1/en not_active Expired - Lifetime
- 2000-07-13 WO PCT/HU2000/000078 patent/WO2001005791A2/en active IP Right Grant
- 2000-07-13 US US10/030,647 patent/US6600039B1/en not_active Expired - Fee Related
- 2000-07-13 AT AT00949822T patent/ATE264842T1/de not_active IP Right Cessation
- 2000-07-13 PL PL00352465A patent/PL195787B1/pl not_active IP Right Cessation
- 2000-07-13 MX MXPA01013344A patent/MXPA01013344A/es active IP Right Grant
- 2000-07-13 ES ES00949822T patent/ES2216927T3/es not_active Expired - Lifetime
- 2000-07-13 DE DE60010083T patent/DE60010083T2/de not_active Expired - Lifetime
- 2000-07-13 BR BR0012425-7A patent/BR0012425A/pt not_active IP Right Cessation
- 2000-07-13 CZ CZ2002145A patent/CZ2002145A3/cs unknown
- 2000-07-13 SK SK46-2002A patent/SK285818B6/sk not_active IP Right Cessation
- 2000-07-13 JP JP2001511450A patent/JP2003505389A/ja not_active Ceased
- 2000-07-13 CN CNB008103143A patent/CN1174969C/zh not_active Expired - Fee Related
- 2000-07-13 AU AU63081/00A patent/AU6308100A/en not_active Abandoned
-
2002
- 2002-02-14 HR HR20020142A patent/HRP20020142B1/hr not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997015556A1 (fr) * | 1995-10-24 | 1997-05-01 | Sanofi | Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine |
Also Published As
Publication number | Publication date |
---|---|
EP1196381A2 (en) | 2002-04-17 |
BR0012425A (pt) | 2002-06-11 |
DE60010083T2 (de) | 2005-03-31 |
ATE264842T1 (de) | 2004-05-15 |
WO2001005791A2 (en) | 2001-01-25 |
MXPA01013344A (es) | 2002-08-20 |
WO2001005791A3 (en) | 2001-07-19 |
CN1420868A (zh) | 2003-05-28 |
PL352465A1 (en) | 2003-08-25 |
HU9902376D0 (en) | 1999-10-28 |
CZ2002145A3 (cs) | 2002-11-13 |
ES2216927T3 (es) | 2004-11-01 |
CA2378087C (en) | 2007-12-18 |
US6600039B1 (en) | 2003-07-29 |
EP1196381B1 (en) | 2004-04-21 |
SK285818B6 (sk) | 2007-09-06 |
PL195787B1 (pl) | 2007-10-31 |
AU6308100A (en) | 2001-02-05 |
CA2378087A1 (en) | 2001-01-25 |
HRP20020142A2 (en) | 2003-12-31 |
SK462002A3 (en) | 2003-03-04 |
HUP9902376A3 (en) | 2002-11-28 |
DE60010083D1 (de) | 2004-05-27 |
JP2003505389A (ja) | 2003-02-12 |
HUP9902376A2 (hu) | 2001-05-28 |
CN1174969C (zh) | 2004-11-10 |
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Owner name: SANOFI-AVENTIS, FR |
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Payment date: 20100813 Year of fee payment: 11 |
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PBON | Lapse due to non-payment of renewal fee |
Effective date: 20110714 |