ATE264842T1 - Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen - Google Patents

Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen

Info

Publication number
ATE264842T1
ATE264842T1 AT00949822T AT00949822T ATE264842T1 AT E264842 T1 ATE264842 T1 AT E264842T1 AT 00949822 T AT00949822 T AT 00949822T AT 00949822 T AT00949822 T AT 00949822T AT E264842 T1 ATE264842 T1 AT E264842T1
Authority
AT
Austria
Prior art keywords
ethoxy
salts
oxospiro
methoxybenzamide
cyclohexan
Prior art date
Application number
AT00949822T
Other languages
English (en)
Inventor
Gergely Heja
Eva Csikos
Takacsy Tuende Erosne
Csaba Goenczi
Judit Halasz
Istvan Hermecz
Csilla Majlath
Lajos Nagy
Csutor Andrea Santane
Peter Sarosi
Kalman Simon
Tiborne Szomor
Gyoergyne Szvoboda
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of ATE264842T1 publication Critical patent/ATE264842T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00949822T 1999-07-15 2000-07-13 Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen ATE264842T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902376A HUP9902376A3 (en) 1999-07-15 1999-07-15 Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts
PCT/HU2000/000078 WO2001005791A2 (en) 1999-07-15 2000-07-13 NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS

Publications (1)

Publication Number Publication Date
ATE264842T1 true ATE264842T1 (de) 2004-05-15

Family

ID=89998742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00949822T ATE264842T1 (de) 1999-07-15 2000-07-13 Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen

Country Status (17)

Country Link
US (1) US6600039B1 (de)
EP (1) EP1196381B1 (de)
JP (1) JP2003505389A (de)
CN (1) CN1174969C (de)
AT (1) ATE264842T1 (de)
AU (1) AU6308100A (de)
BR (1) BR0012425A (de)
CA (1) CA2378087C (de)
CZ (1) CZ2002145A3 (de)
DE (1) DE60010083T2 (de)
ES (1) ES2216927T3 (de)
HR (1) HRP20020142B1 (de)
HU (1) HUP9902376A3 (de)
MX (1) MXPA01013344A (de)
PL (1) PL195787B1 (de)
SK (1) SK285818B6 (de)
WO (1) WO2001005791A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4823614A (en) * 1986-04-28 1989-04-25 Dahlin Erik B Coriolis-type mass flowmeter
WO2003011827A1 (en) * 2001-07-31 2003-02-13 Sanofi-Synthelabo Process for the preparation of 3-spiro'cyclohexam-1,3'-'3h!indolin-2'-one! derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740136B1 (fr) 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
MXPA01013344A (es) 2002-08-20
CA2378087A1 (en) 2001-01-25
PL195787B1 (pl) 2007-10-31
WO2001005791A3 (en) 2001-07-19
HRP20020142A2 (en) 2003-12-31
DE60010083T2 (de) 2005-03-31
US6600039B1 (en) 2003-07-29
JP2003505389A (ja) 2003-02-12
HU9902376D0 (en) 1999-10-28
CN1174969C (zh) 2004-11-10
HUP9902376A3 (en) 2002-11-28
SK285818B6 (sk) 2007-09-06
BR0012425A (pt) 2002-06-11
SK462002A3 (en) 2003-03-04
CA2378087C (en) 2007-12-18
EP1196381A2 (de) 2002-04-17
ES2216927T3 (es) 2004-11-01
PL352465A1 (en) 2003-08-25
HUP9902376A2 (hu) 2001-05-28
HRP20020142B1 (en) 2010-09-30
DE60010083D1 (de) 2004-05-27
WO2001005791A2 (en) 2001-01-25
EP1196381B1 (de) 2004-04-21
AU6308100A (en) 2001-02-05
CN1420868A (zh) 2003-05-28
CZ2002145A3 (cs) 2002-11-13

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