BR0012425A - Processo para a preparação de n-(1,1-dimetiletil)-4-[[5'-etoxi-4-cis[2-(4-morfolino)etoxi] -2'-oxospiro[ciclohexan-1,3'-[3h]indol]-1'(2'h)-il]-sulfoni l]-3-metoxibenzamida e seus sais - Google Patents
Processo para a preparação de n-(1,1-dimetiletil)-4-[[5'-etoxi-4-cis[2-(4-morfolino)etoxi] -2'-oxospiro[ciclohexan-1,3'-[3h]indol]-1'(2'h)-il]-sulfoni l]-3-metoxibenzamida e seus saisInfo
- Publication number
- BR0012425A BR0012425A BR0012425-7A BR0012425A BR0012425A BR 0012425 A BR0012425 A BR 0012425A BR 0012425 A BR0012425 A BR 0012425A BR 0012425 A BR0012425 A BR 0012425A
- Authority
- BR
- Brazil
- Prior art keywords
- ethoxy
- salts
- preparation
- oxospiro
- cis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Abstract
"PROCESSO PARA A PREPARAçãO DE N-( 1,1DIMETILETIL )-4-[ [5'-ETOXI-4-CIS[ 2-( 4-MORFOLINO )ETOXI ]-2'OXOSPIRO [ CICLOHEXAN-1,3'-[ 3H ]INDOL ]-1'( 2'H )-IL ]-SULFONIL ]-3METAXIBENZAMIDA E SEUS SAIS". A invenção se refere a um processo para a preparação do composto de fórmula ( I ) e seus sais, mediante a reação do composto de fórmula ( II ) com o composto de fórmula ( III ), o que compreende realizar a reação em sulfóxido de dimetila, a uma temperatura entre 10 <198>C e 40 <198>C, preferivelmente na temperatura ambiente e transformar a base resultante de fórmula ( I ), se desejado, na forma de seu sal através de um método propriamente conhecido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9902376A HUP9902376A3 (en) | 1999-07-15 | 1999-07-15 | Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts |
PCT/HU2000/000078 WO2001005791A2 (en) | 1999-07-15 | 2000-07-13 | NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012425A true BR0012425A (pt) | 2002-06-11 |
Family
ID=89998742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012425-7A BR0012425A (pt) | 1999-07-15 | 2000-07-13 | Processo para a preparação de n-(1,1-dimetiletil)-4-[[5'-etoxi-4-cis[2-(4-morfolino)etoxi] -2'-oxospiro[ciclohexan-1,3'-[3h]indol]-1'(2'h)-il]-sulfoni l]-3-metoxibenzamida e seus sais |
Country Status (17)
Country | Link |
---|---|
US (1) | US6600039B1 (pt) |
EP (1) | EP1196381B1 (pt) |
JP (1) | JP2003505389A (pt) |
CN (1) | CN1174969C (pt) |
AT (1) | ATE264842T1 (pt) |
AU (1) | AU6308100A (pt) |
BR (1) | BR0012425A (pt) |
CA (1) | CA2378087C (pt) |
CZ (1) | CZ2002145A3 (pt) |
DE (1) | DE60010083T2 (pt) |
ES (1) | ES2216927T3 (pt) |
HR (1) | HRP20020142B1 (pt) |
HU (1) | HUP9902376A3 (pt) |
MX (1) | MXPA01013344A (pt) |
PL (1) | PL195787B1 (pt) |
SK (1) | SK285818B6 (pt) |
WO (1) | WO2001005791A2 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4823614A (en) * | 1986-04-28 | 1989-04-25 | Dahlin Erik B | Coriolis-type mass flowmeter |
DE60204154T2 (de) * | 2001-07-31 | 2006-01-19 | Sanofi-Aventis | Verfahren zur herstellung von 3 spiro'cyclohexan-1,3'-'3h!indolin-2'-on!derivaten |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2740136B1 (fr) | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
1999
- 1999-07-15 HU HU9902376A patent/HUP9902376A3/hu unknown
-
2000
- 2000-07-13 CA CA002378087A patent/CA2378087C/en not_active Expired - Fee Related
- 2000-07-13 EP EP00949822A patent/EP1196381B1/en not_active Expired - Lifetime
- 2000-07-13 WO PCT/HU2000/000078 patent/WO2001005791A2/en active IP Right Grant
- 2000-07-13 US US10/030,647 patent/US6600039B1/en not_active Expired - Fee Related
- 2000-07-13 AT AT00949822T patent/ATE264842T1/de not_active IP Right Cessation
- 2000-07-13 PL PL00352465A patent/PL195787B1/pl not_active IP Right Cessation
- 2000-07-13 MX MXPA01013344A patent/MXPA01013344A/es active IP Right Grant
- 2000-07-13 ES ES00949822T patent/ES2216927T3/es not_active Expired - Lifetime
- 2000-07-13 DE DE60010083T patent/DE60010083T2/de not_active Expired - Lifetime
- 2000-07-13 BR BR0012425-7A patent/BR0012425A/pt not_active IP Right Cessation
- 2000-07-13 CZ CZ2002145A patent/CZ2002145A3/cs unknown
- 2000-07-13 SK SK46-2002A patent/SK285818B6/sk not_active IP Right Cessation
- 2000-07-13 JP JP2001511450A patent/JP2003505389A/ja not_active Ceased
- 2000-07-13 CN CNB008103143A patent/CN1174969C/zh not_active Expired - Fee Related
- 2000-07-13 AU AU63081/00A patent/AU6308100A/en not_active Abandoned
-
2002
- 2002-02-14 HR HR20020142A patent/HRP20020142B1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1196381A2 (en) | 2002-04-17 |
DE60010083T2 (de) | 2005-03-31 |
ATE264842T1 (de) | 2004-05-15 |
WO2001005791A2 (en) | 2001-01-25 |
MXPA01013344A (es) | 2002-08-20 |
WO2001005791A3 (en) | 2001-07-19 |
CN1420868A (zh) | 2003-05-28 |
PL352465A1 (en) | 2003-08-25 |
HU9902376D0 (en) | 1999-10-28 |
CZ2002145A3 (cs) | 2002-11-13 |
ES2216927T3 (es) | 2004-11-01 |
CA2378087C (en) | 2007-12-18 |
US6600039B1 (en) | 2003-07-29 |
EP1196381B1 (en) | 2004-04-21 |
SK285818B6 (sk) | 2007-09-06 |
PL195787B1 (pl) | 2007-10-31 |
AU6308100A (en) | 2001-02-05 |
CA2378087A1 (en) | 2001-01-25 |
HRP20020142A2 (en) | 2003-12-31 |
SK462002A3 (en) | 2003-03-04 |
HUP9902376A3 (en) | 2002-11-28 |
DE60010083D1 (de) | 2004-05-27 |
JP2003505389A (ja) | 2003-02-12 |
HUP9902376A2 (hu) | 2001-05-28 |
CN1174969C (zh) | 2004-11-10 |
HRP20020142B1 (en) | 2010-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved | ||
B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS (FR) Free format text: ALTERADO DE: SANOFI-SYNTHELABO |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI. |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS ANUIDADES EM DEBITO. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2332 DE 15/09/2015. |