HRP20020013A2 - SELECTIVE iGluR<SUB>5</SUB> RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE - Google Patents
SELECTIVE iGluR<SUB>5</SUB> RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE Download PDFInfo
- Publication number
- HRP20020013A2 HRP20020013A2 HR20020013A HRP20020013A HRP20020013A2 HR P20020013 A2 HRP20020013 A2 HR P20020013A2 HR 20020013 A HR20020013 A HR 20020013A HR P20020013 A HRP20020013 A HR P20020013A HR P20020013 A2 HRP20020013 A2 HR P20020013A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- methyl
- compound
- decahydroisoquinoline
- receptor
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14248599P | 1999-07-06 | 1999-07-06 | |
| US15116599P | 1999-08-27 | 1999-08-27 | |
| PCT/US2000/016297 WO2001001972A2 (en) | 1999-07-06 | 2000-06-27 | SELECTIVE iGluR5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20020013A2 true HRP20020013A2 (en) | 2003-08-31 |
Family
ID=26840135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020013A HRP20020013A2 (en) | 1999-07-06 | 2002-01-07 | SELECTIVE iGluR<SUB>5</SUB> RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US6566370B1 (da) |
| EP (1) | EP1200073B1 (da) |
| JP (1) | JP4619595B2 (da) |
| KR (1) | KR20020024300A (da) |
| CN (1) | CN1230174C (da) |
| AR (1) | AR029373A1 (da) |
| AU (1) | AU773304B2 (da) |
| BR (1) | BR0012175A (da) |
| CA (1) | CA2378613C (da) |
| CZ (1) | CZ20014488A3 (da) |
| DE (1) | DE60032905T2 (da) |
| DK (1) | DK1200073T3 (da) |
| DZ (1) | DZ3209A1 (da) |
| EA (1) | EA004290B1 (da) |
| ES (1) | ES2278619T3 (da) |
| HK (1) | HK1047036A1 (da) |
| HR (1) | HRP20020013A2 (da) |
| HU (1) | HUP0202253A3 (da) |
| IL (1) | IL146697A0 (da) |
| MX (1) | MXPA01012726A (da) |
| MY (1) | MY133503A (da) |
| NO (1) | NO20016246L (da) |
| NZ (1) | NZ515616A (da) |
| PE (1) | PE20010299A1 (da) |
| PT (1) | PT1200073E (da) |
| SK (1) | SK112002A3 (da) |
| TR (1) | TR200200066T2 (da) |
| WO (1) | WO2001001972A2 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046173A1 (en) * | 1999-12-22 | 2001-06-28 | Eli Lilly And Company | SELECTIVE iGLUR5 RECEPTOR ANTAGONISTS |
| AU2002228736A1 (en) * | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Pyrrolidinylmethyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists |
| DK1368032T3 (da) * | 2001-01-05 | 2008-09-29 | Lilly Co Eli | Exitatoriske aminosyrereceptorantagonister |
| US6924294B2 (en) | 2001-01-05 | 2005-08-02 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| HUP0302528A2 (hu) * | 2001-01-05 | 2003-11-28 | Eli Lilly And Co. | Ingerlő aminosav receptor antagonisták és e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| WO2002053139A2 (en) * | 2001-01-05 | 2002-07-11 | Eli Lilly And Company | Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders |
| US7205313B2 (en) | 2001-01-05 | 2007-04-17 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| EP1351951A2 (en) | 2001-01-05 | 2003-10-15 | Eli Lilly And Company | Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists |
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| US20040082606A1 (en) * | 2001-12-20 | 2004-04-29 | Khau Vien Van | Excitatory amino acid receptor antagonists |
| EP1511741B1 (en) | 2002-04-26 | 2012-12-26 | Eli Lilly And Company | Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| NZ575652A (en) | 2006-08-23 | 2011-08-26 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8722929B2 (en) | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| CN101578259A (zh) | 2006-11-28 | 2009-11-11 | 威朗国际制药公司 | 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物 |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| CA3066711A1 (en) | 2017-07-31 | 2019-02-07 | Novartis Ag | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| WO2019171258A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Pharmaceutica Nv | Assays to detect neurodegeneration |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5356902A (en) * | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| US5767117A (en) | 1994-11-18 | 1998-06-16 | The General Hospital Corporation | Method for treating vascular headaches |
| AU734657B2 (en) * | 1997-04-07 | 2001-06-21 | Eli Lilly And Company | Pharmacological agents |
| WO2001002367A2 (en) | 1999-07-06 | 2001-01-11 | Eli Lilly And Company | Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid |
-
2000
- 2000-06-27 EA EA200200132A patent/EA004290B1/ru not_active IP Right Cessation
- 2000-06-27 CZ CZ20014488A patent/CZ20014488A3/cs unknown
- 2000-06-27 DK DK00944671T patent/DK1200073T3/da active
- 2000-06-27 ES ES00944671T patent/ES2278619T3/es not_active Expired - Lifetime
- 2000-06-27 DE DE60032905T patent/DE60032905T2/de not_active Expired - Lifetime
- 2000-06-27 US US10/009,655 patent/US6566370B1/en not_active Expired - Fee Related
- 2000-06-27 CN CNB008096880A patent/CN1230174C/zh not_active Expired - Fee Related
- 2000-06-27 HU HU0202253A patent/HUP0202253A3/hu unknown
- 2000-06-27 BR BR0012175-4A patent/BR0012175A/pt not_active Application Discontinuation
- 2000-06-27 CA CA002378613A patent/CA2378613C/en not_active Expired - Fee Related
- 2000-06-27 MX MXPA01012726A patent/MXPA01012726A/es active IP Right Grant
- 2000-06-27 PT PT00944671T patent/PT1200073E/pt unknown
- 2000-06-27 IL IL14669700A patent/IL146697A0/xx unknown
- 2000-06-27 WO PCT/US2000/016297 patent/WO2001001972A2/en active IP Right Grant
- 2000-06-27 TR TR2002/00066T patent/TR200200066T2/xx unknown
- 2000-06-27 EP EP00944671A patent/EP1200073B1/en not_active Expired - Lifetime
- 2000-06-27 KR KR1020027000138A patent/KR20020024300A/ko not_active Application Discontinuation
- 2000-06-27 AU AU58732/00A patent/AU773304B2/en not_active Ceased
- 2000-06-27 DZ DZ003209A patent/DZ3209A1/xx active
- 2000-06-27 NZ NZ515616A patent/NZ515616A/en unknown
- 2000-06-27 JP JP2001507466A patent/JP4619595B2/ja not_active Expired - Fee Related
- 2000-06-27 SK SK11-2002A patent/SK112002A3/sk not_active Application Discontinuation
- 2000-06-29 AR ARP000103296A patent/AR029373A1/es unknown
- 2000-07-04 PE PE2000000672A patent/PE20010299A1/es not_active Application Discontinuation
- 2000-07-04 MY MYPI20003046 patent/MY133503A/en unknown
-
2001
- 2001-12-19 NO NO20016246A patent/NO20016246L/no not_active Application Discontinuation
-
2002
- 2002-01-07 HR HR20020013A patent/HRP20020013A2/hr not_active Application Discontinuation
- 2002-09-27 HK HK02107174.1A patent/HK1047036A1/zh unknown
-
2003
- 2003-03-06 US US10/383,296 patent/US6759418B2/en not_active Expired - Fee Related
-
2004
- 2004-04-09 US US10/821,698 patent/US6855823B2/en not_active Expired - Fee Related
-
2005
- 2005-01-11 US US11/032,759 patent/US7157582B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| OBST | Application withdrawn |