HUP0302528A2 - Ingerlő aminosav receptor antagonisták és e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására - Google Patents
Ingerlő aminosav receptor antagonisták és e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállításáraInfo
- Publication number
- HUP0302528A2 HUP0302528A2 HU0302528A HUP0302528A HUP0302528A2 HU P0302528 A2 HUP0302528 A2 HU P0302528A2 HU 0302528 A HU0302528 A HU 0302528A HU P0302528 A HUP0302528 A HU P0302528A HU P0302528 A2 HUP0302528 A2 HU P0302528A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- compounds
- pharmaceutically acceptable
- subject
- general formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940123511 Excitatory amino acid receptor antagonist Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 4
- XTEGVFVZDVNBPF-UHFFFAOYSA-N naphthalene-1,5-disulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- IWYDHOAUDWTVEP-SSDOTTSWSA-N (R)-mandelic acid Chemical group OC(=O)[C@H](O)C1=CC=CC=C1 IWYDHOAUDWTVEP-SSDOTTSWSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 206010027603 Migraine headaches Diseases 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- NWCHELUCVWSRRS-UHFFFAOYSA-N atrolactic acid Chemical class OC(=O)C(O)(C)C1=CC=CC=C1 NWCHELUCVWSRRS-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát az (I) képletű vegyület gyógyászatilag megfelelősói vagy prekurzorjai, valamint az (la) általános képletű vegyületgyógyászatilag megfelelő sója képezi; ahol gyógyászatilag megfelelősóként metil-(-)-mandulasavsót vagy 1,5-naftalin-diszulfonsavatalkalmaznak A találmány tárgyát képezik e vegyületeket tartalmazógyógyászati készítmények, valamint a vegyületek alkalmazásagyógyászati készítmények előállítására. A találmány tárgyához tartozikaz (la) általános képletű vegyületek előállítására szolgáló eljárásis. Az (la) általános képletben a szubsztituensek jelentése az alábbi:R1 és R2 jelentése egymástól függetlenül hidrogénatom, 1-20 szénatomosalkil-, 2-6 szénatomos alkenil-, (1-6 szénatomos alkil)-aril-, (1-6szénatomos alkil)-(3-10 szénatomos cikloalkil)-, (1-6 szénatomosalkil)-N,N-(1-6 szénatomos dialkil)-amin-, (1-6 szénatomos alkil)-pirrolidin-, (1-6 szénatomos alkil)-piperidin- vagy (1-6 szénatomosalkil)-morfolin-csoport, azzal a feltétellel, hogy R1 és R2 közüllegalább az egyik jelentése hidrogénatomtól eltérő; ahol agyógyászatilag megfelelő só D-(-)-mandulasavsó vagy 1,5-naftalin-diszulfonsavsó közül választott. A találmány szerinti vegyületek aziGIuR5 receptor receptoraltípus szelektív antagonistái és ezérteredményesen adhatók különböző neurológiai rendellenességek ésneurodegeneratív betegségek kezelésére anélkül, hogy nemkívánatosmellékhatásokkal kellene számolni. A találmány szerinti vegyületekeredményesen alkalmazhatók különböző fájdalmak, így a súlyos, krónikusfájdalmak, különösen a migrénes fejfájás kezelésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26001401P | 2001-01-05 | 2001-01-05 | |
| PCT/US2001/044715 WO2002053561A1 (en) | 2001-01-05 | 2001-12-20 | Excitatory amino acid receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0302528A2 true HUP0302528A2 (hu) | 2003-11-28 |
Family
ID=22987455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302528A HUP0302528A2 (hu) | 2001-01-05 | 2001-12-20 | Ingerlő aminosav receptor antagonisták és e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1351955A1 (hu) |
| JP (1) | JP2004520335A (hu) |
| KR (1) | KR20030066797A (hu) |
| CN (1) | CN1484642A (hu) |
| AR (1) | AR035679A1 (hu) |
| BR (1) | BR0116672A (hu) |
| CA (1) | CA2431545A1 (hu) |
| CZ (1) | CZ20031856A3 (hu) |
| DZ (1) | DZ3460A1 (hu) |
| EA (1) | EA200300770A1 (hu) |
| EC (1) | ECSP034682A (hu) |
| HR (1) | HRP20030544A2 (hu) |
| HU (1) | HUP0302528A2 (hu) |
| IL (1) | IL156138A0 (hu) |
| MX (1) | MXPA03005981A (hu) |
| NO (1) | NO20032973D0 (hu) |
| NZ (1) | NZ525821A (hu) |
| PE (1) | PE20020792A1 (hu) |
| PL (1) | PL361934A1 (hu) |
| SK (1) | SK8242003A3 (hu) |
| TW (1) | TW591023B (hu) |
| WO (1) | WO2002053561A1 (hu) |
| ZA (1) | ZA200304311B (hu) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| JP2002505254A (ja) * | 1998-02-06 | 2002-02-19 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | パロキセチン塩 |
| GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
| TR200200066T2 (tr) * | 1999-07-06 | 2002-04-22 | Eli Lilly And Company | Migrenin tedavisi için seçici iGluR5 reseptör antagonistleri |
-
2001
- 2001-12-20 KR KR10-2003-7008977A patent/KR20030066797A/ko not_active Application Discontinuation
- 2001-12-20 NZ NZ525821A patent/NZ525821A/en unknown
- 2001-12-20 HU HU0302528A patent/HUP0302528A2/hu unknown
- 2001-12-20 WO PCT/US2001/044715 patent/WO2002053561A1/en not_active Application Discontinuation
- 2001-12-20 EA EA200300770A patent/EA200300770A1/ru unknown
- 2001-12-20 CZ CZ20031856A patent/CZ20031856A3/cs unknown
- 2001-12-20 IL IL15613801A patent/IL156138A0/xx unknown
- 2001-12-20 EP EP01995980A patent/EP1351955A1/en not_active Withdrawn
- 2001-12-20 PL PL01361934A patent/PL361934A1/xx not_active Application Discontinuation
- 2001-12-20 BR BR0116672-7A patent/BR0116672A/pt not_active IP Right Cessation
- 2001-12-20 CA CA002431545A patent/CA2431545A1/en not_active Abandoned
- 2001-12-20 JP JP2002554680A patent/JP2004520335A/ja active Pending
- 2001-12-20 DZ DZ013460A patent/DZ3460A1/fr active
- 2001-12-20 MX MXPA03005981A patent/MXPA03005981A/es unknown
- 2001-12-20 SK SK824-2003A patent/SK8242003A3/sk unknown
- 2001-12-20 CN CNA018217508A patent/CN1484642A/zh active Pending
-
2002
- 2002-01-04 AR ARP020100030A patent/AR035679A1/es not_active Application Discontinuation
- 2002-01-04 TW TW091100071A patent/TW591023B/zh not_active IP Right Cessation
- 2002-01-04 PE PE2002000003A patent/PE20020792A1/es not_active Application Discontinuation
-
2003
- 2003-06-02 ZA ZA200304311A patent/ZA200304311B/en unknown
- 2003-06-27 NO NO20032973A patent/NO20032973D0/no not_active Application Discontinuation
- 2003-07-03 EC EC2003004682A patent/ECSP034682A/es unknown
- 2003-07-03 HR HR20030544A patent/HRP20030544A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK8242003A3 (en) | 2004-01-08 |
| IL156138A0 (en) | 2003-12-23 |
| NO20032973L (no) | 2003-06-27 |
| AR035679A1 (es) | 2004-06-23 |
| BR0116672A (pt) | 2003-09-23 |
| EA200300770A1 (ru) | 2003-10-30 |
| CA2431545A1 (en) | 2002-07-11 |
| DZ3460A1 (fr) | 2002-07-11 |
| PL361934A1 (en) | 2004-10-18 |
| MXPA03005981A (es) | 2003-09-10 |
| ZA200304311B (en) | 2004-09-02 |
| NO20032973D0 (no) | 2003-06-27 |
| CZ20031856A3 (cs) | 2003-09-17 |
| CN1484642A (zh) | 2004-03-24 |
| WO2002053561A1 (en) | 2002-07-11 |
| JP2004520335A (ja) | 2004-07-08 |
| NZ525821A (en) | 2004-07-30 |
| KR20030066797A (ko) | 2003-08-09 |
| ECSP034682A (es) | 2003-08-29 |
| TW591023B (en) | 2004-06-11 |
| EP1351955A1 (en) | 2003-10-15 |
| HRP20030544A2 (en) | 2004-08-31 |
| PE20020792A1 (es) | 2002-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |