HRP20010797A2 - eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING - Google Patents
eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING Download PDFInfo
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- HRP20010797A2 HRP20010797A2 HR20010797A HRP20010797A HRP20010797A2 HR P20010797 A2 HRP20010797 A2 HR P20010797A2 HR 20010797 A HR20010797 A HR 20010797A HR P20010797 A HRP20010797 A HR P20010797A HR P20010797 A2 HRP20010797 A2 HR P20010797A2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
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- Engineering & Computer Science (AREA)
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| US12955099P | 1999-04-16 | 1999-04-16 | |
| PCT/US2000/009913 WO2000062605A1 (en) | 1999-04-16 | 2000-04-14 | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010797A2 true HRP20010797A2 (en) | 2003-02-28 |
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| HR20010797A HRP20010797A2 (en) | 1999-04-16 | 2001-10-29 | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US6900038B2 (xx) |
| EP (1) | EP1178722A4 (xx) |
| JP (1) | JP2002541829A (xx) |
| KR (1) | KR100737945B1 (xx) |
| CN (1) | CN100357433C (xx) |
| AU (2) | AU774010B2 (xx) |
| BG (1) | BG106051A (xx) |
| BR (1) | BR0009805A (xx) |
| CA (1) | CA2369764A1 (xx) |
| CZ (1) | CZ20013427A3 (xx) |
| EE (1) | EE200100538A (xx) |
| HK (1) | HK1046081B (xx) |
| HR (1) | HRP20010797A2 (xx) |
| HU (1) | HUP0200799A3 (xx) |
| IL (1) | IL145760A0 (xx) |
| MX (1) | MXPA01010459A (xx) |
| NO (1) | NO20015008L (xx) |
| NZ (1) | NZ514305A (xx) |
| PL (1) | PL351087A1 (xx) |
| RU (1) | RU2257226C2 (xx) |
| SK (1) | SK14692001A3 (xx) |
| UA (1) | UA76939C2 (xx) |
| WO (1) | WO2000062605A1 (xx) |
| YU (1) | YU73301A (xx) |
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| WO2000062605A1 (en) * | 1999-04-16 | 2000-10-26 | Yale University | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
| AU2003276711A1 (en) | 2002-06-14 | 2003-12-31 | Wisconsin Alumni Research Foundation | Ribonuclease zymogen design |
| CN100408101C (zh) * | 2002-08-16 | 2008-08-06 | 舍林股份公司 | 以野生型或突变型eNOS对重症肢体缺血的基因治疗 |
| RU2005107410A (ru) * | 2002-08-16 | 2006-01-20 | Шеринг Акциенгезельшафт (De) | Мутанты enos, пригодные для генной терапии |
| GB0226463D0 (en) * | 2002-11-13 | 2002-12-18 | Isis Innovation | Mimicking the athletic heart |
| JP4623719B2 (ja) * | 2002-12-02 | 2011-02-02 | アンジェスＭｇ株式会社 | 血管形成依存性症状を治療または予防する方法 |
| WO2006023879A1 (en) * | 2004-08-20 | 2006-03-02 | Board Of Regents, The University Of Texas System | Screening of agents for activity against ischemic myocardial insults |
| US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
| US20060067937A1 (en) * | 2004-09-24 | 2006-03-30 | Karumanchi S A | Methods of diagnosing and treating complications of pregnancy |
| CA2654283A1 (en) * | 2006-05-31 | 2008-03-13 | Beth Israel Deaconess Medical Center, Inc. | Methods of diagnosing and treating complications of pregnancy |
| US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
| CN103983634A (zh) * | 2008-07-22 | 2014-08-13 | 普罗美加公司 | 基于adp检测的发光磷酸转移酶或atp水解酶测定 |
| RU2520748C2 (ru) * | 2008-12-04 | 2014-06-27 | Санофи | Способы и применения, включающие гемсвязывающий белок 1 |
| RU2526575C2 (ru) * | 2012-11-02 | 2014-08-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ повышения иммуносупрессивных свойств мезенхимальных стромальных клеток жировой ткани |
| US9677117B2 (en) | 2014-10-08 | 2017-06-13 | Promega Corporation | Bioluminescent succinate detection assay |
| CN107802826B (zh) * | 2017-10-26 | 2020-02-18 | 首都医科大学宣武医院 | eNOS突变体在促进血管生成中的应用 |
| CN116790603B (zh) * | 2023-08-18 | 2023-10-31 | 成都中科奥格生物科技有限公司 | 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途 |
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| US5498539A (en) * | 1992-07-02 | 1996-03-12 | Daiichi Pharmaceutical Co., Ltd. | Bovine endothelial nitric oxide synthase nucleic acids |
| US5658565A (en) * | 1994-06-24 | 1997-08-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inducible nitric oxide synthase gene for treatment of disease |
| DE4411402A1 (de) * | 1994-03-31 | 1995-10-05 | Juergen Schrader | DNA-Expressionsvektoren zur Verwendung in der gentherapeutischen Behandlung von Gefäßerkrankungen |
| FR2722507B1 (fr) * | 1994-07-12 | 1996-08-14 | Rhone Poulenc Rorer Sa | Adenovirus comportant un gene codant pour une no synthase |
| US5968983A (en) * | 1994-10-05 | 1999-10-19 | Nitrosystems, Inc | Method and formulation for treating vascular disease |
| US5837534A (en) * | 1995-11-14 | 1998-11-17 | The Board Of Regents Of The University Of Texas System | Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells |
| JP2002528390A (ja) * | 1998-10-02 | 2002-09-03 | セント エリザベス メディカル センター， インコーポレイテッド | 細胞の生存を増強するためのａｋｔ組成物 |
| PT1144600E (pt) * | 1999-03-19 | 2008-10-10 | Aventis Pharma Inc | Ácidos nucleicos akt-3, polipeptídeos e as suas utilizações |
| WO2000062605A1 (en) * | 1999-04-16 | 2000-10-26 | Yale University | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
| MXPA01012748A (es) * | 1999-06-11 | 2002-07-02 | Aventis Pharm Prod Inc | Induccion de factor de crecimiento del endotelio vascular (vegf) por la serina/treonina proteina cinasa akt. |
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