FR2722507B1 - Adenovirus comportant un gene codant pour une no synthase - Google Patents

Adenovirus comportant un gene codant pour une no synthase

Info

Publication number
FR2722507B1
FR2722507B1 FR9408657A FR9408657A FR2722507B1 FR 2722507 B1 FR2722507 B1 FR 2722507B1 FR 9408657 A FR9408657 A FR 9408657A FR 9408657 A FR9408657 A FR 9408657A FR 2722507 B1 FR2722507 B1 FR 2722507B1
Authority
FR
France
Prior art keywords
adenovirus
synthase
gene encoding
gene
encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9408657A
Other languages
English (en)
Other versions
FR2722507A1 (fr
Inventor
Andrees Bohme
Didier Branellec
Patrice Denefle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9408657A priority Critical patent/FR2722507B1/fr
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to PCT/FR1995/000913 priority patent/WO1996001902A1/fr
Priority to CA002193263A priority patent/CA2193263A1/fr
Priority to AU29306/95A priority patent/AU691008B2/en
Priority to JP8504161A priority patent/JPH10502533A/ja
Priority to MX9700298A priority patent/MX9700298A/es
Priority to EP95925025A priority patent/EP0770133A1/fr
Priority to IL11456595A priority patent/IL114565A0/xx
Priority to ZA955797A priority patent/ZA955797B/xx
Publication of FR2722507A1 publication Critical patent/FR2722507A1/fr
Application granted granted Critical
Publication of FR2722507B1 publication Critical patent/FR2722507B1/fr
Priority to NO970048A priority patent/NO970048D0/no
Priority to FI970114A priority patent/FI970114A0/fi
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075—Nitric-oxide synthase (1.14.13.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
FR9408657A 1994-07-12 1994-07-12 Adenovirus comportant un gene codant pour une no synthase Expired - Fee Related FR2722507B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9408657A FR2722507B1 (fr) 1994-07-12 1994-07-12 Adenovirus comportant un gene codant pour une no synthase
CA002193263A CA2193263A1 (fr) 1994-07-12 1995-07-07 Adenovirus comportant un gene codant pour une no synthase
AU29306/95A AU691008B2 (en) 1994-07-12 1995-07-07 Adenovirus comprising a gene coding for an no synthase
JP8504161A JPH10502533A (ja) 1994-07-12 1995-07-07 Ｎｏシンターゼをコードする遺伝子を含むアデノウイルス
MX9700298A MX9700298A (es) 1994-07-12 1995-07-07 Adenovirus que comprende un gen que codifica para una no sintasa.
EP95925025A EP0770133A1 (fr) 1994-07-12 1995-07-07 Adenovirus comportant un gene codant pour une no synthase
PCT/FR1995/000913 WO1996001902A1 (fr) 1994-07-12 1995-07-07 Adenovirus comportant un gene codant pour une no synthase
IL11456595A IL114565A0 (en) 1994-07-12 1995-07-12 Adenovirus comprising a sequence encoding for an no synthase
ZA955797A ZA955797B (en) 1994-07-12 1995-07-12 Adenovirus comprising a sequence coding for an NO synthase
NO970048A NO970048D0 (no) 1994-07-12 1997-01-07 Adénovirus omfattende et gen som koder for en NO-syntase
FI970114A FI970114A0 (fi) 1994-07-12 1997-01-10 NO-syntaasia koodaavan geenin käsittävä adenovirus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408657A FR2722507B1 (fr) 1994-07-12 1994-07-12 Adenovirus comportant un gene codant pour une no synthase

Publications (2)

Publication Number Publication Date
FR2722507A1 FR2722507A1 (fr) 1996-01-19
FR2722507B1 true FR2722507B1 (fr) 1996-08-14

Family

ID=9465319

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9408657A Expired - Fee Related FR2722507B1 (fr) 1994-07-12 1994-07-12 Adenovirus comportant un gene codant pour une no synthase

Country Status (11)

Country Link
EP (1) EP0770133A1 (fr)
JP (1) JPH10502533A (fr)
AU (1) AU691008B2 (fr)
CA (1) CA2193263A1 (fr)
FI (1) FI970114A0 (fr)
FR (1) FR2722507B1 (fr)
IL (1) IL114565A0 (fr)
MX (1) MX9700298A (fr)
NO (1) NO970048D0 (fr)
WO (1) WO1996001902A1 (fr)
ZA (1) ZA955797B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833651A (en) * 1996-11-08 1998-11-10 Medtronic, Inc. Therapeutic intraluminal stents
AU753027B2 (en) * 1998-02-11 2002-10-03 Genvec, Inc. Vectors, cells and methods for the production of deleterious viral eukaryotic gene transfer vectors
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
EP1020520A1 (fr) * 1999-01-15 2000-07-19 Introgene B.V. Prévention d'élimination immunologiques des cellules du corps mammifère, molécules PML mutantes utiles à cet effet
NZ514305A (en) * 1999-04-16 2004-01-30 Univ Yale eNOS mutations useful for gene therapy and therapeutic screening
FR2793142A1 (fr) * 1999-05-04 2000-11-10 Aventis Pharma Sa Utilisation d'oligonucleotides antisens de no-synthase inductible dans la prevention et le traitement de l'ischemie cerebrale
WO2000066725A1 (fr) * 1999-05-04 2000-11-09 Aventis Pharma S.A. Utilisation d'oligonucleotides antisens de no-synthase inductible dans la prevention et le traitement de l'ischemie cerebrale
EP1067190A1 (fr) * 1999-07-09 2001-01-10 Introgene B.V. Thérapie génique pour l'amélioration et/ou induction de l'angiogénèse
EP1076091A1 (fr) * 1999-08-09 2001-02-14 Universite Catholique De Louvain Composé ou composition pharmaceutique pour la prévention et/ou le traitement d'ischémie cardiaque, de maladies vasculaires périphériques, de tumeurs et de plaies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
AU694097B2 (en) * 1992-11-18 1998-07-16 Arch Development Corporation Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle
FR2704556B1 (fr) * 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2705361B1 (fr) * 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
WO1994028721A1 (fr) * 1993-06-11 1994-12-22 The Board Of Trustees Of The Leland Stanford Junior University Traitement des maladies vasculaires degeneratives par modulation de l'activite ou de la production d'oxyde nitrique endogene
FR2707494B1 (fr) * 1993-07-02 1995-08-25 Roussel Uclaf Nouvelle utilisation de dérivés de la béta-naphtoquinone ainsi que de leurs sels.
US6682728B1 (en) * 1993-10-13 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Efficient and selective adenoviral-mediated gene transfer into vascular neointima

Also Published As

Publication number Publication date
EP0770133A1 (fr) 1997-05-02
FR2722507A1 (fr) 1996-01-19
JPH10502533A (ja) 1998-03-10
AU691008B2 (en) 1998-05-07
AU2930695A (en) 1996-02-09
ZA955797B (en) 1996-02-26
IL114565A0 (en) 1995-11-27
CA2193263A1 (fr) 1996-01-25
WO1996001902A1 (fr) 1996-01-25
NO970048L (no) 1997-01-07
NO970048D0 (no) 1997-01-07
FI970114A (fi) 1997-01-10
FI970114A0 (fi) 1997-01-10
MX9700298A (es) 1997-05-31

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