HRP20010759A2 - Novel synthesis of piperazine ring - Google Patents

Novel synthesis of piperazine ring Download PDF

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Publication number
HRP20010759A2
HRP20010759A2 HR20010759A HRP20010759A HRP20010759A2 HR P20010759 A2 HRP20010759 A2 HR P20010759A2 HR 20010759 A HR20010759 A HR 20010759A HR P20010759 A HRP20010759 A HR P20010759A HR P20010759 A2 HRP20010759 A2 HR P20010759A2
Authority
HR
Croatia
Prior art keywords
acid
group
formula
compound
aryl
Prior art date
Application number
HR20010759A
Other languages
English (en)
Croatian (hr)
Inventor
Ben-Zion Dolitzky
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of HRP20010759A2 publication Critical patent/HRP20010759A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20010759A 1999-04-19 2000-04-07 Novel synthesis of piperazine ring HRP20010759A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13004899P 1999-04-19 1999-04-19
PCT/US2000/009418 WO2000063185A1 (en) 1999-04-19 2000-04-07 Novel synthesis of piperazine ring

Publications (1)

Publication Number Publication Date
HRP20010759A2 true HRP20010759A2 (en) 2003-02-28

Family

ID=22442818

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010759A HRP20010759A2 (en) 1999-04-19 2000-04-07 Novel synthesis of piperazine ring

Country Status (19)

Country Link
US (2) US6339156B1 (cs)
EP (1) EP1178972A4 (cs)
JP (1) JP2002542234A (cs)
KR (1) KR20020015313A (cs)
CN (1) CN1355793A (cs)
AU (1) AU777105B2 (cs)
CA (1) CA2370389A1 (cs)
CZ (1) CZ20013698A3 (cs)
HK (1) HK1042696A1 (cs)
HR (1) HRP20010759A2 (cs)
HU (1) HUP0200808A3 (cs)
IL (1) IL146024A0 (cs)
PL (1) PL351395A1 (cs)
RU (1) RU2001128228A (cs)
SK (1) SK14802001A3 (cs)
TR (1) TR200103035T2 (cs)
WO (1) WO2000063185A1 (cs)
YU (1) YU74201A (cs)
ZA (1) ZA200108480B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20013698A3 (cs) * 1999-04-19 2002-05-15 Teva Pharmaceutical Industries Ltd. Nová syntéza piperazinového kruhu
WO2001025185A1 (fr) 1999-09-30 2001-04-12 Sumika Fine Chemicals Co., Ltd. Procede de production de derive de piperazine
AU6474200A (en) * 1999-12-13 2001-06-18 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
EP1426356B1 (en) 2001-09-14 2008-04-16 Medichem S.A. Intermediate compounds for the preparation of mirtazapine and the production methods thereof
US7041826B2 (en) * 2003-06-02 2006-05-09 Aurobindo Pharma Ltd. Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate
CN102153620A (zh) * 2005-09-26 2011-08-17 住友化学株式会社 光学活性的哌嗪化合物的制造方法
CN101440067B (zh) * 2007-11-21 2010-08-25 上海津力化工有限公司 一种药物中间体1-甲基-3-苯基哌嗪的制备方法
CN102649779A (zh) * 2012-04-20 2012-08-29 山东鲁药制药有限公司 一种药物中间体1-甲基-3-苯基哌嗪的合成方法
AU2016222550B2 (en) 2015-02-27 2020-07-16 Dechra Limited Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2891063A (en) * 1959-06-16 Piperazine derivatives and process of
US2830056A (en) * 1958-04-08 Chj oh
US2507408A (en) * 1948-03-05 1950-05-09 Rhone Poulenc Sa 1-alkylsulfonyl-4-alkyl piperazines
GB1181322A (en) * 1967-06-29 1970-02-11 Chugai Pharmaceutical Co Ltd Piperazine Derivatives and processes for preparing the same
NL179906C (nl) * 1974-02-09 1986-12-01 Akzo Nv Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten.
US4217452A (en) * 1974-02-09 1980-08-12 Akzona Incorporated Synthesis for the preparation of tetracyclic compounds
NL189199C (nl) 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
FR2585702B1 (fr) * 1985-07-31 1989-03-03 Lafon Labor Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique
US4918190A (en) * 1986-08-06 1990-04-17 Ube Industries, Ltd. Crystalline complex compounds of propargyl alcohols and tertiary diamines, and process of separation and purification of propargyl alcohols using the same
US4935515A (en) * 1988-02-23 1990-06-19 American Home Products Corporation 2,3,4,5-tetrahydro-1H-[1,2,5]triazocino(1,2-a)[1,2,4]benzotriazin-7(8H)-ones, thiones and derivatives
CZ20013698A3 (cs) * 1999-04-19 2002-05-15 Teva Pharmaceutical Industries Ltd. Nová syntéza piperazinového kruhu

Also Published As

Publication number Publication date
HUP0200808A3 (en) 2002-12-28
IL146024A0 (en) 2002-07-25
HK1042696A1 (zh) 2002-08-23
JP2002542234A (ja) 2002-12-10
AU777105B2 (en) 2004-09-30
ZA200108480B (en) 2003-01-29
RU2001128228A (ru) 2003-07-20
CA2370389A1 (en) 2000-10-26
TR200103035T2 (tr) 2002-01-21
US20020035256A1 (en) 2002-03-21
CN1355793A (zh) 2002-06-26
US6339156B1 (en) 2002-01-15
PL351395A1 (en) 2003-04-07
US6852855B2 (en) 2005-02-08
EP1178972A1 (en) 2002-02-13
YU74201A (sh) 2004-05-12
SK14802001A3 (sk) 2002-07-02
EP1178972A4 (en) 2002-06-12
AU4219000A (en) 2000-11-02
WO2000063185A1 (en) 2000-10-26
KR20020015313A (ko) 2002-02-27
HUP0200808A2 (hu) 2002-11-28
CZ20013698A3 (cs) 2002-05-15

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