HRP20010189A2 - Dry powder active agent pulmonary delivery - Google Patents
Dry powder active agent pulmonary delivery Download PDFInfo
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- HRP20010189A2 HRP20010189A2 HR20010189A HRP20010189A HRP20010189A2 HR P20010189 A2 HRP20010189 A2 HR P20010189A2 HR 20010189 A HR20010189 A HR 20010189A HR P20010189 A HRP20010189 A HR P20010189A HR P20010189 A2 HRP20010189 A2 HR P20010189A2
- Authority
- HR
- Croatia
- Prior art keywords
- particles
- hygroscopicity
- particle growth
- powder
- cyclodextrin
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10016398P | 1998-09-14 | 1998-09-14 | |
| PCT/US1999/021109 WO2000015262A1 (fr) | 1998-09-14 | 1999-09-13 | Administration par voie pulmonaire d'un agent actif sous forme de poudre seche |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010189A2 true HRP20010189A2 (en) | 2005-04-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010189A HRP20010189A2 (en) | 1998-09-14 | 2001-03-14 | Dry powder active agent pulmonary delivery |
Country Status (44)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1185248B1 (fr) | 1999-06-09 | 2012-05-02 | Robert E. Sievers | Nebulisation et sechage de bulles assiste par un fluide supercritique |
| US6475468B2 (en) * | 2001-02-15 | 2002-11-05 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| CA2446904A1 (fr) * | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Administration d'esters medicamenteux par inhalation |
| EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
| JP2005518453A (ja) | 2002-02-25 | 2005-06-23 | ディフュージョン・ファーマシューティカルズ・エルエルシー | 二極性トランスカロテノイド塩およびそれらの使用 |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| CA2491129A1 (fr) * | 2002-07-03 | 2004-01-15 | Brigham And Women's Hospital, Inc. | Introduction par les voies aeriennes centrales pour l'administration systemique d'agents therapeutiques |
| EP1575563B1 (fr) * | 2002-12-19 | 2007-02-14 | Pharmacia Corporation | Formulation a caractere non-hygroscopique comprenant un principe actif hydroscopique |
| DE10338403A1 (de) * | 2003-08-18 | 2005-03-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| JP2007534693A (ja) * | 2004-04-23 | 2007-11-29 | サイデックス・インコーポレイテッド | スルホアルキルエーテルシクロデキストリンを含有するｄｐｉ製剤 |
| AU2006229688B2 (en) * | 2005-02-24 | 2012-07-26 | Diffusion Pharmaceuticals Llc | Trans carotenoids, their synthesis, formulation and uses |
| EP1857114A1 (fr) * | 2005-03-09 | 2007-11-21 | Ono Pharmaceutical Co., Ltd. | Particule et preparation la contenant |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| PT2335707E (pt) | 2005-10-26 | 2015-09-10 | Cydex Pharmaceuticals Inc | Composições de éter sulfoalquílico de ciclodextrina e métodos para a sua preparação |
| US20080035143A1 (en) * | 2006-08-14 | 2008-02-14 | Sievers Robert E | Human-powered dry powder inhaler and dry powder inhaler compositions |
| EP2095812A4 (fr) * | 2006-10-25 | 2011-07-13 | Dainippon Sumitomo Pharma Co | Préparation granulaire non agglutinante |
| EP1925295A1 (fr) * | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Formule de poudre stable contenant un nouveau anticholinergique |
| CN101687757A (zh) | 2007-04-13 | 2010-03-31 | 扩散药品有限公司 | 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用 |
| CA2703946A1 (fr) | 2007-10-31 | 2009-05-07 | Diffusion Pharmaceuticals Llc | Nouvelle classe d'agents therapeutiques qui ameliorent la diffusion des petites molecules |
| TR201802619T4 (tr) * | 2009-05-20 | 2018-03-21 | Aeras | Kararlı, sprey ile kurutulmuş, immunojen, viral bileşimler. |
| AU2010263245A1 (en) | 2009-06-22 | 2012-01-19 | Diffusion Pharmaceuticals Llc | Diffusion enhancing compounds and their use alone or with thrombolytics |
| CA2801292C (fr) | 2010-06-02 | 2019-01-22 | Diffusion Pharmaceuticals Llc | Formes pharmaceutiques orales a base de carotenoides trans bipolaires |
| CA2866230C (fr) | 2012-05-03 | 2020-08-18 | Janssen R&D Ireland | Formulations d'acide polyinosinique-polycytidylique (poly (i:c)) pour le traitement d'infections du tractus respiratoire superieur |
| BR112015010601B1 (pt) * | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | Composição farmacêutica e uso da composição |
| WO2015042352A1 (fr) * | 2013-09-20 | 2015-03-26 | Virginia Commonwealth University | Administration de particules à l'aide d'excipients hygroscopiques |
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| JP7032320B2 (ja) | 2016-03-24 | 2022-03-08 | ディフュージョン・ファーマシューティカルズ・エルエルシー | 癌を処置するための、化学療法及び放射線療法を伴う二極性トランスカロテノイドの使用 |
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| US3155573A (en) * | 1958-05-06 | 1964-11-03 | Benger Lab Ltd | Inhalant composition and method of making same |
| CA2115065C (fr) * | 1992-06-12 | 2000-10-03 | Kiyoyuki Sakon | Poudre particulaire ultrafine pour inhalation et methode de production |
| US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| PT954282E (pt) * | 1997-01-16 | 2005-06-30 | Massachusetts Inst Technology | Preparacao de particulas para inalacao |
| US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
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