HRP20010167A2 - 4,4-biarylpiperidine derivatives with opioid receptor activity - Google Patents
4,4-biarylpiperidine derivatives with opioid receptor activity Download PDFInfo
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- HRP20010167A2 HRP20010167A2 HR20010167A HRP20010167A HRP20010167A2 HR P20010167 A2 HRP20010167 A2 HR P20010167A2 HR 20010167 A HR20010167 A HR 20010167A HR P20010167 A HRP20010167 A HR P20010167A HR P20010167 A2 HRP20010167 A2 HR P20010167A2
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- Prior art keywords
- alkyl
- comp
- phenyl
- pain
- addiction
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- 102000003840 Opioid Receptors Human genes 0.000 title claims description 22
- 108090000137 Opioid Receptors Proteins 0.000 title claims description 22
- 230000000694 effects Effects 0.000 title description 8
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 60
- -1 aryl-(C1-C8) alkyl- Chemical group 0.000 claims description 54
- 208000035475 disorder Diseases 0.000 claims description 49
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 34
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- 238000009739 binding Methods 0.000 claims description 22
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- 125000003118 aryl group Chemical group 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 18
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- 150000003852 triazoles Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9956598P | 1998-09-09 | 1998-09-09 | |
PCT/IB1999/001512 WO2000014066A1 (fr) | 1998-09-09 | 1999-09-06 | Derives de 4,4-biarylpiperidine possedant une activite de recepteur opioide |
Publications (1)
Publication Number | Publication Date |
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HRP20010167A2 true HRP20010167A2 (en) | 2002-02-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20010167A HRP20010167A2 (en) | 1998-09-09 | 2001-03-08 | 4,4-biarylpiperidine derivatives with opioid receptor activity |
Country Status (41)
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US (2) | US6720336B2 (fr) |
EP (1) | EP1112255B1 (fr) |
JP (1) | JP2002524445A (fr) |
KR (1) | KR20010075024A (fr) |
CN (1) | CN1316993A (fr) |
AP (1) | AP2001002088A0 (fr) |
AR (1) | AR022376A1 (fr) |
AT (1) | ATE312819T1 (fr) |
AU (1) | AU749096B2 (fr) |
BG (1) | BG105411A (fr) |
BR (1) | BR9913512A (fr) |
CA (1) | CA2343236C (fr) |
CO (1) | CO5170416A1 (fr) |
CZ (1) | CZ2001850A3 (fr) |
DE (1) | DE69928945T2 (fr) |
EA (1) | EA200100203A1 (fr) |
EE (1) | EE200100145A (fr) |
ES (1) | ES2252960T3 (fr) |
GE (1) | GEP20033025B (fr) |
GT (1) | GT199900146A (fr) |
HK (1) | HK1040396A1 (fr) |
HN (1) | HN1999000149A (fr) |
HR (1) | HRP20010167A2 (fr) |
HU (1) | HUP0103542A3 (fr) |
ID (1) | ID29129A (fr) |
IL (1) | IL141506A0 (fr) |
IS (1) | IS5860A (fr) |
MA (1) | MA26686A1 (fr) |
NO (1) | NO20011183L (fr) |
NZ (1) | NZ509841A (fr) |
OA (1) | OA11648A (fr) |
PA (1) | PA8481301A1 (fr) |
PE (1) | PE20001053A1 (fr) |
PL (1) | PL346648A1 (fr) |
SK (1) | SK3032001A3 (fr) |
SV (1) | SV1999000147A (fr) |
TN (1) | TNSN99169A1 (fr) |
TR (1) | TR200100694T2 (fr) |
WO (1) | WO2000014066A1 (fr) |
YU (1) | YU11501A (fr) |
ZA (1) | ZA200101744B (fr) |
Families Citing this family (39)
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US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
EP1038872A1 (fr) | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | Dérivés de 4-phényl-4-hétéroarylpiperdine comme ligands des récepteurs opioides |
SE9902765D0 (sv) * | 1999-07-21 | 1999-07-21 | Astra Pharma Prod | Novel compounds |
US6974824B2 (en) * | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
EP1279666A1 (fr) * | 2001-07-24 | 2003-01-29 | Pfizer Products Inc. | Dérivés de 1-diphenylméthyl-pyrazoles comme ligands des récepteurs opioides |
AU2003210916B9 (en) | 2002-02-07 | 2008-12-18 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203301D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
PL378268A1 (pl) | 2002-11-26 | 2006-03-20 | Pfizer Products Inc. | Aktywatory PPAR |
DK2368554T3 (en) * | 2003-04-08 | 2015-01-26 | Progenics Pharm Inc | A pharmaceutical composition comprising methylnaltrexone |
CL2004000754A1 (es) * | 2003-04-11 | 2005-02-25 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central. |
US20070078120A1 (en) * | 2003-10-21 | 2007-04-05 | Hitoshi Ban | Novel piperidine derivative |
NZ547696A (en) | 2003-12-23 | 2009-12-24 | Astex Therapeutics Ltd | Pyrazole derivatives as protein kinase modulators |
EP1584335A3 (fr) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Combinaison de substances actives comprenant un composé carbinol et un opioïde |
US7872023B2 (en) * | 2005-02-17 | 2011-01-18 | Research Triangle Institute | Kappa opioid receptor ligands |
MX2007010833A (es) * | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
WO2006136823A1 (fr) * | 2005-06-21 | 2006-12-28 | Astex Therapeutics Limited | Amine contenant des heterocycliques comme inhibiteurs des kinases b |
EP1902032A1 (fr) | 2005-06-22 | 2008-03-26 | Astex Therapeutics Limited | Composes pharmaceutiques |
EP1933832A2 (fr) | 2005-06-23 | 2008-06-25 | Astex Therapeutics Limited | Combinaisons pharmaceutiques comprenant des derives de pyrazole en tant que modulateurs de proteine kinase |
DE102005061427A1 (de) * | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
SI2565195T1 (sl) | 2007-03-29 | 2015-09-30 | Wyeth Llc | Periferalni opioidni receptorji in antagonisti in njih uporaba |
CN101801979A (zh) | 2007-03-29 | 2010-08-11 | 普罗热尼奇制药公司 | (r)-n-溴化甲基纳曲酮的晶体形式及其用途 |
CA2865661C (fr) | 2007-03-29 | 2016-05-17 | Progenics Pharmaceuticals, Inc. | Antagonistes de recepteurs opioides peripheriques, et leurs utilisations |
JP5358587B2 (ja) | 2008-02-06 | 2013-12-04 | プロジェニックス・ファーマシューティカルス・インコーポレイテッド | (r),(r)−2,2’−ビス−メチルナルトレキソンの製造及び用途 |
CA2719134C (fr) * | 2008-03-21 | 2015-06-30 | The University Of Chicago | Traitement avec des antagonistes des opioides et des inhibiteurs mtor |
CA2676881C (fr) | 2008-09-30 | 2017-04-25 | Wyeth | Antagonistes de recepteurs opioides peripheriques, et leurs utilisations |
EP2263664A1 (fr) * | 2009-05-18 | 2010-12-22 | Nestec S.A. | Composé (thymoquinone, Nigella sativa) stimulant les récepteurs opioïdes et allergie alimentaire |
KR102603671B1 (ko) * | 2017-01-17 | 2023-11-17 | 메비아스 디스커버리 인코포레이티드 | 치환된 3-디알킬아미노메틸-피페리딘-4-일-벤즈아미드 및 이를 제조 및 사용하는 방법 |
US11584765B2 (en) | 2017-03-12 | 2023-02-21 | Ecstasy LLC | Polycyclic amines as sigma receptor modulators |
EP3595661A4 (fr) * | 2017-03-12 | 2020-08-19 | Xiaodong Wang | Amines polycycliques utilisées comme modulateurs des récepteurs opioïdes |
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DE1936452C3 (de) * | 1969-07-17 | 1975-06-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur Herstellung von 4,4-Diphenylpiperidlnen |
US4016280A (en) | 1969-07-17 | 1977-04-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 4,4-Diarylpiperidine compositions and use |
DE2139085C3 (de) * | 1971-08-04 | 1979-01-18 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Halogenierte 4,4-Diphenyl-piperidine, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel |
DE2139084C3 (de) | 1971-08-04 | 1979-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur Herstellung von 4,4-Diphenyl-piperidinen |
DE2166997C3 (de) | 1971-08-04 | 1980-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur Herstellung von 4,4-Diphenyl-piperidinen |
ES2066721B1 (es) * | 1993-05-18 | 1996-02-16 | Ferrer Int | Nuevos compuestos derivados de la piridina 1,4-disustituida. |
US5434171A (en) * | 1993-12-08 | 1995-07-18 | Eli Lilly And Company | Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates |
US5994369A (en) * | 1995-04-05 | 1999-11-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted piperidine or pyrrolidine compounds for treating sigma-receptor modulated disorders |
EP1021185A4 (fr) | 1996-05-16 | 2005-09-07 | Synaptic Pharma Corp | Dihydropyrimidines et leurs emplois |
CA2255727A1 (fr) | 1996-05-31 | 1997-12-04 | Trophix Pharmaceuticals, Inc. | Produit pharmaceutique pour le traitement de troubles neurologiques et neuropsychiatriques |
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