HRP20000261B1 - 1'-(4-(1-(4-fluorophenyl)-1h-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3h), 4' -piperidine) hydrohalogenides - Google Patents

1'-(4-(1-(4-fluorophenyl)-1h-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3h), 4' -piperidine) hydrohalogenides

Info

Publication number
HRP20000261B1
HRP20000261B1 HR20000261A HRP20000261A HRP20000261B1 HR P20000261 B1 HRP20000261 B1 HR P20000261B1 HR 20000261 A HR20000261 A HR 20000261A HR P20000261 A HRP20000261 A HR P20000261A HR P20000261 B1 HRP20000261 B1 HR P20000261B1
Authority
HR
Croatia
Prior art keywords
isobenzofuran
spiro
fluorophenyl
piperidine
butyl
Prior art date
Application number
HR20000261A
Other languages
English (en)
Croatian (hr)
Inventor
Niels Mork
Lopez De Diego Heidi
Nielsen Ole
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20000261A2 publication Critical patent/HRP20000261A2/hr
Publication of HRP20000261B1 publication Critical patent/HRP20000261B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20000261A 1997-11-07 2000-05-04 1'-(4-(1-(4-fluorophenyl)-1h-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3h), 4' -piperidine) hydrohalogenides HRP20000261B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK126797 1997-11-07
PCT/DK1998/000480 WO1999024436A1 (en) 1997-11-07 1998-11-06 1'-[4-[1- (4-fluorophenyl)- 1h-indole-3-yl] -1-butyl]-spiro [isobenzofuran- 1(3h),4'- piperidine] hydrohalogenides

Publications (2)

Publication Number Publication Date
HRP20000261A2 HRP20000261A2 (en) 2001-04-30
HRP20000261B1 true HRP20000261B1 (en) 2009-04-30

Family

ID=8102935

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000261A HRP20000261B1 (en) 1997-11-07 2000-05-04 1'-(4-(1-(4-fluorophenyl)-1h-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3h), 4' -piperidine) hydrohalogenides

Country Status (39)

Country Link
US (2) US6844352B2 (no)
EP (1) EP1044202B1 (no)
JP (1) JP3605358B2 (no)
KR (1) KR100399274B1 (no)
CN (1) CN1105115C (no)
AR (1) AR023010A1 (no)
AT (1) ATE288918T1 (no)
AU (1) AU749094B2 (no)
BG (1) BG64906B1 (no)
BR (1) BR9813949A (no)
CA (1) CA2308745C (no)
CZ (1) CZ288666B6 (no)
DE (1) DE69828999T2 (no)
DZ (1) DZ2642A1 (no)
EA (1) EA002092B1 (no)
EG (1) EG23791A (no)
ES (1) ES2234162T3 (no)
HK (1) HK1034075A1 (no)
HR (1) HRP20000261B1 (no)
HU (1) HUP0100991A3 (no)
ID (1) ID25776A (no)
IL (1) IL135723A (no)
IS (1) IS2342B (no)
JO (1) JO2052B1 (no)
MA (1) MA25585A1 (no)
NO (1) NO325920B1 (no)
NZ (1) NZ504065A (no)
PE (1) PE130299A1 (no)
PL (1) PL190538B1 (no)
PT (1) PT1044202E (no)
RS (1) RS49777B (no)
SK (1) SK285245B6 (no)
TN (1) TNSN98201A1 (no)
TR (1) TR200001267T2 (no)
TW (1) TW483894B (no)
UA (1) UA64769C2 (no)
UY (1) UY25236A1 (no)
WO (1) WO1999024436A1 (no)
ZA (1) ZA9810116B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013789A1 (en) * 2000-08-15 2002-02-21 H. Lundbeck A/S Pharmaceutical composition containing 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl] -1-butyl]-spiro[isobenzofuran-1(3h),4'-piperidine]
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US20050020483A1 (en) 2003-06-12 2005-01-27 Donna Oksenberg Sigma ligands for neuronal regeneration and functional recovery
DE112006002660A5 (de) * 2005-07-29 2008-07-10 Sigma-Aldrich Production Gmbh Ionisierungsadditive enthaltende LC/MS-Blends
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007104035A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2009002496A (es) * 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2066355A2 (en) * 2006-09-19 2009-06-10 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022554A1 (en) * 1991-06-13 1992-12-23 H. Lundbeck A/S Piperidine derivates having anxiolytic effect

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022554A1 (en) * 1991-06-13 1992-12-23 H. Lundbeck A/S Piperidine derivates having anxiolytic effect

Also Published As

Publication number Publication date
IL135723A0 (en) 2001-05-20
PE130299A1 (es) 1999-12-16
TNSN98201A1 (fr) 2005-03-15
JO2052B1 (en) 1999-05-15
PL340220A1 (en) 2001-01-15
PT1044202E (pt) 2005-04-29
EP1044202B1 (en) 2005-02-09
TR200001267T2 (tr) 2000-09-21
SK6462000A3 (en) 2000-10-09
CZ20001663A3 (cs) 2000-10-11
IS5460A (is) 2000-04-18
HRP20000261A2 (en) 2001-04-30
US20050171135A1 (en) 2005-08-04
AU1022699A (en) 1999-05-31
ID25776A (id) 2000-11-02
CN1105115C (zh) 2003-04-09
JP2001522852A (ja) 2001-11-20
IL135723A (en) 2005-11-20
UA64769C2 (uk) 2004-03-15
US6844352B2 (en) 2005-01-18
YU23500A (sh) 2003-12-31
HUP0100991A2 (hu) 2001-09-28
NZ504065A (en) 2002-05-31
SK285245B6 (sk) 2006-09-07
KR20010031791A (ko) 2001-04-16
CA2308745A1 (en) 1999-05-20
NO20002188L (no) 2000-06-14
US20030055074A1 (en) 2003-03-20
JP3605358B2 (ja) 2004-12-22
BR9813949A (pt) 2000-09-26
PL190538B1 (pl) 2005-12-30
ZA9810116B (en) 1999-05-07
RS49777B (sr) 2008-06-05
WO1999024436A1 (en) 1999-05-20
KR100399274B1 (ko) 2003-09-26
EA200000502A1 (ru) 2000-10-30
CN1278823A (zh) 2001-01-03
IS2342B (is) 2008-02-15
TW483894B (en) 2002-04-21
EG23791A (en) 2007-08-13
ES2234162T3 (es) 2005-06-16
ATE288918T1 (de) 2005-02-15
HK1034075A1 (en) 2001-10-12
EA002092B1 (ru) 2001-12-24
MA25585A1 (fr) 2002-12-31
DE69828999T2 (de) 2005-07-21
UY25236A1 (es) 2000-12-29
BG64906B1 (bg) 2006-08-31
DZ2642A1 (fr) 2004-12-28
EP1044202A1 (en) 2000-10-18
CZ288666B6 (cs) 2001-08-15
DE69828999D1 (de) 2005-03-17
NO20002188D0 (no) 2000-04-27
BG104485A (en) 2001-01-31
AR023010A1 (es) 2002-09-04
CA2308745C (en) 2004-01-20
HUP0100991A3 (en) 2003-03-28
NO325920B1 (no) 2008-08-18
AU749094B2 (en) 2002-06-20

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Effective date: 20091107