HK1034075A1 - 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl]-1-butyl]-spiro [isobenzofuran-1(3h),4'-piperidine] hydrohalogenides - Google Patents

1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl]-1-butyl]-spiro [isobenzofuran-1(3h),4'-piperidine] hydrohalogenides

Info

Publication number
HK1034075A1
HK1034075A1 HK01104490A HK01104490A HK1034075A1 HK 1034075 A1 HK1034075 A1 HK 1034075A1 HK 01104490 A HK01104490 A HK 01104490A HK 01104490 A HK01104490 A HK 01104490A HK 1034075 A1 HK1034075 A1 HK 1034075A1
Authority
HK
Hong Kong
Prior art keywords
hydrohalogenides
isobenzofuran
spiro
fluorophenyl
indole
Prior art date
Application number
HK01104490A
Other languages
English (en)
Inventor
Niels Mork
De Diego Heidi Lopez
Ole Nielsen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of HK1034075A1 publication Critical patent/HK1034075A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK01104490A 1997-11-07 2001-06-28 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl]-1-butyl]-spiro [isobenzofuran-1(3h),4'-piperidine] hydrohalogenides HK1034075A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK126797 1997-11-07
PCT/DK1998/000480 WO1999024436A1 (en) 1997-11-07 1998-11-06 1'-[4-[1- (4-fluorophenyl)- 1h-indole-3-yl] -1-butyl]-spiro [isobenzofuran- 1(3h),4'- piperidine] hydrohalogenides

Publications (1)

Publication Number Publication Date
HK1034075A1 true HK1034075A1 (en) 2001-10-12

Family

ID=8102935

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01104490A HK1034075A1 (en) 1997-11-07 2001-06-28 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl]-1-butyl]-spiro [isobenzofuran-1(3h),4'-piperidine] hydrohalogenides

Country Status (39)

Country Link
US (2) US6844352B2 (no)
EP (1) EP1044202B1 (no)
JP (1) JP3605358B2 (no)
KR (1) KR100399274B1 (no)
CN (1) CN1105115C (no)
AR (1) AR023010A1 (no)
AT (1) ATE288918T1 (no)
AU (1) AU749094B2 (no)
BG (1) BG64906B1 (no)
BR (1) BR9813949A (no)
CA (1) CA2308745C (no)
CZ (1) CZ288666B6 (no)
DE (1) DE69828999T2 (no)
DZ (1) DZ2642A1 (no)
EA (1) EA002092B1 (no)
EG (1) EG23791A (no)
ES (1) ES2234162T3 (no)
HK (1) HK1034075A1 (no)
HR (1) HRP20000261B1 (no)
HU (1) HUP0100991A3 (no)
ID (1) ID25776A (no)
IL (1) IL135723A (no)
IS (1) IS2342B (no)
JO (1) JO2052B1 (no)
MA (1) MA25585A1 (no)
NO (1) NO325920B1 (no)
NZ (1) NZ504065A (no)
PE (1) PE130299A1 (no)
PL (1) PL190538B1 (no)
PT (1) PT1044202E (no)
RS (1) RS49777B (no)
SK (1) SK285245B6 (no)
TN (1) TNSN98201A1 (no)
TR (1) TR200001267T2 (no)
TW (1) TW483894B (no)
UA (1) UA64769C2 (no)
UY (1) UY25236A1 (no)
WO (1) WO1999024436A1 (no)
ZA (1) ZA9810116B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001279607A1 (en) * 2000-08-15 2002-02-25 H. Lundbeck, A/S Pharmaceutical composition containing 1'-(4-(1-(4-fluorophenyl)-1h-indole-3-yl) -1-butyl)-spiro(isobenzofuran-1(3h),4'-piperidine)
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
EP1644026A4 (en) * 2003-06-12 2007-10-24 Ms Science Corp SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECREATION
US20090306341A1 (en) * 2005-07-29 2009-12-10 Joachim Emmert LC/MS Blends Containing Ionizing Additives
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) * 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
EP2066355A2 (en) * 2006-09-19 2009-06-10 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
CZ288666B6 (cs) 2001-08-15
HRP20000261A2 (en) 2001-04-30
US6844352B2 (en) 2005-01-18
NO20002188L (no) 2000-06-14
HRP20000261B1 (en) 2009-04-30
AU1022699A (en) 1999-05-31
YU23500A (sh) 2003-12-31
CZ20001663A3 (cs) 2000-10-11
SK6462000A3 (en) 2000-10-09
BG64906B1 (bg) 2006-08-31
DE69828999T2 (de) 2005-07-21
IS5460A (is) 2000-04-18
EG23791A (en) 2007-08-13
US20030055074A1 (en) 2003-03-20
ZA9810116B (en) 1999-05-07
EP1044202B1 (en) 2005-02-09
MA25585A1 (fr) 2002-12-31
NO20002188D0 (no) 2000-04-27
RS49777B (sr) 2008-06-05
BR9813949A (pt) 2000-09-26
US20050171135A1 (en) 2005-08-04
WO1999024436A1 (en) 1999-05-20
DZ2642A1 (fr) 2004-12-28
EA200000502A1 (ru) 2000-10-30
HUP0100991A2 (hu) 2001-09-28
SK285245B6 (sk) 2006-09-07
TR200001267T2 (tr) 2000-09-21
CN1105115C (zh) 2003-04-09
UA64769C2 (uk) 2004-03-15
IL135723A0 (en) 2001-05-20
PT1044202E (pt) 2005-04-29
JO2052B1 (en) 1999-05-15
KR100399274B1 (ko) 2003-09-26
PL340220A1 (en) 2001-01-15
ID25776A (id) 2000-11-02
CN1278823A (zh) 2001-01-03
PE130299A1 (es) 1999-12-16
NO325920B1 (no) 2008-08-18
TW483894B (en) 2002-04-21
JP2001522852A (ja) 2001-11-20
HUP0100991A3 (en) 2003-03-28
NZ504065A (en) 2002-05-31
EA002092B1 (ru) 2001-12-24
IS2342B (is) 2008-02-15
IL135723A (en) 2005-11-20
DE69828999D1 (de) 2005-03-17
AR023010A1 (es) 2002-09-04
CA2308745C (en) 2004-01-20
EP1044202A1 (en) 2000-10-18
ATE288918T1 (de) 2005-02-15
ES2234162T3 (es) 2005-06-16
JP3605358B2 (ja) 2004-12-22
TNSN98201A1 (fr) 2005-03-15
KR20010031791A (ko) 2001-04-16
CA2308745A1 (en) 1999-05-20
AU749094B2 (en) 2002-06-20
UY25236A1 (es) 2000-12-29
BG104485A (en) 2001-01-31
PL190538B1 (pl) 2005-12-30

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091106