ZA9810116B - 1'-4(4-(1-(4-fluorophenyl)-1H-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3H),4'-piperidine)hydrohalogenides - Google Patents
1'-4(4-(1-(4-fluorophenyl)-1H-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3H),4'-piperidine)hydrohalogenidesInfo
- Publication number
- ZA9810116B ZA9810116B ZA9810116A ZA9810116A ZA9810116B ZA 9810116 B ZA9810116 B ZA 9810116B ZA 9810116 A ZA9810116 A ZA 9810116A ZA 9810116 A ZA9810116 A ZA 9810116A ZA 9810116 B ZA9810116 B ZA 9810116B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrohalogenides
- isobenzofuran
- spiro
- fluorophenyl
- indole
- Prior art date
Links
- -1 4-(1-(4-fluorophenyl)-1H-indole-3-yl)-1-butyl Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK126797 | 1997-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9810116B true ZA9810116B (en) | 1999-05-07 |
Family
ID=8102935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9810116A ZA9810116B (en) | 1997-11-07 | 1998-11-05 | 1'-4(4-(1-(4-fluorophenyl)-1H-indole-3-yl)-1-butyl)-spiro (isobenzofuran-1(3H),4'-piperidine)hydrohalogenides |
Country Status (39)
Country | Link |
---|---|
US (2) | US6844352B2 (xx) |
EP (1) | EP1044202B1 (xx) |
JP (1) | JP3605358B2 (xx) |
KR (1) | KR100399274B1 (xx) |
CN (1) | CN1105115C (xx) |
AR (1) | AR023010A1 (xx) |
AT (1) | ATE288918T1 (xx) |
AU (1) | AU749094B2 (xx) |
BG (1) | BG64906B1 (xx) |
BR (1) | BR9813949A (xx) |
CA (1) | CA2308745C (xx) |
CZ (1) | CZ288666B6 (xx) |
DE (1) | DE69828999T2 (xx) |
DZ (1) | DZ2642A1 (xx) |
EA (1) | EA002092B1 (xx) |
EG (1) | EG23791A (xx) |
ES (1) | ES2234162T3 (xx) |
HK (1) | HK1034075A1 (xx) |
HR (1) | HRP20000261B1 (xx) |
HU (1) | HUP0100991A3 (xx) |
ID (1) | ID25776A (xx) |
IL (1) | IL135723A (xx) |
IS (1) | IS2342B (xx) |
JO (1) | JO2052B1 (xx) |
MA (1) | MA25585A1 (xx) |
NO (1) | NO325920B1 (xx) |
NZ (1) | NZ504065A (xx) |
PE (1) | PE130299A1 (xx) |
PL (1) | PL190538B1 (xx) |
PT (1) | PT1044202E (xx) |
RS (1) | RS49777B (xx) |
SK (1) | SK285245B6 (xx) |
TN (1) | TNSN98201A1 (xx) |
TR (1) | TR200001267T2 (xx) |
TW (1) | TW483894B (xx) |
UA (1) | UA64769C2 (xx) |
UY (1) | UY25236A1 (xx) |
WO (1) | WO1999024436A1 (xx) |
ZA (1) | ZA9810116B (xx) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002013789A1 (en) * | 2000-08-15 | 2002-02-21 | H. Lundbeck A/S | Pharmaceutical composition containing 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl] -1-butyl]-spiro[isobenzofuran-1(3h),4'-piperidine] |
AU2003263155A1 (en) * | 2002-09-20 | 2004-04-08 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
WO2004110389A2 (en) * | 2003-06-12 | 2004-12-23 | Agy Therapeutics, Inc. | Sigma ligands for neuronal regeneration and functional recovery |
DE112006002660A5 (de) * | 2005-07-29 | 2008-07-10 | Sigma-Aldrich Production Gmbh | Ionisierungsadditive enthaltende LC/MS-Blends |
EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
AU2007223036A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
US20080103165A1 (en) * | 2006-09-19 | 2008-05-01 | Braincells, Inc. | Ppar mediated modulation of neurogenesis |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5109002A (en) * | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
-
1998
- 1998-06-11 UA UA2000052828A patent/UA64769C2/uk unknown
- 1998-10-20 TW TW087117299A patent/TW483894B/zh not_active IP Right Cessation
- 1998-10-27 MA MA25316A patent/MA25585A1/fr unknown
- 1998-11-03 EG EG136298A patent/EG23791A/xx active
- 1998-11-04 TN TNTNSN98201A patent/TNSN98201A1/fr unknown
- 1998-11-04 DZ DZ980252A patent/DZ2642A1/xx active
- 1998-11-05 AR ARP980105596A patent/AR023010A1/es active IP Right Grant
- 1998-11-05 PE PE1998001067A patent/PE130299A1/es not_active Application Discontinuation
- 1998-11-05 ZA ZA9810116A patent/ZA9810116B/xx unknown
- 1998-11-05 JO JO19982052A patent/JO2052B1/en active
- 1998-11-06 AT AT98952580T patent/ATE288918T1/de not_active IP Right Cessation
- 1998-11-06 CZ CZ20001663A patent/CZ288666B6/cs not_active IP Right Cessation
- 1998-11-06 HU HU0100991A patent/HUP0100991A3/hu unknown
- 1998-11-06 WO PCT/DK1998/000480 patent/WO1999024436A1/en active IP Right Grant
- 1998-11-06 CA CA002308745A patent/CA2308745C/en not_active Expired - Fee Related
- 1998-11-06 KR KR10-2000-7004858A patent/KR100399274B1/ko not_active IP Right Cessation
- 1998-11-06 RS YUP-235/00A patent/RS49777B/sr unknown
- 1998-11-06 ES ES98952580T patent/ES2234162T3/es not_active Expired - Lifetime
- 1998-11-06 DE DE69828999T patent/DE69828999T2/de not_active Expired - Fee Related
- 1998-11-06 BR BR9813949-5A patent/BR9813949A/pt not_active Application Discontinuation
- 1998-11-06 PL PL98340220A patent/PL190538B1/pl not_active IP Right Cessation
- 1998-11-06 TR TR2000/01267T patent/TR200001267T2/xx unknown
- 1998-11-06 ID IDW20000997D patent/ID25776A/id unknown
- 1998-11-06 IL IL13572398A patent/IL135723A/xx not_active IP Right Cessation
- 1998-11-06 PT PT98952580T patent/PT1044202E/pt unknown
- 1998-11-06 UY UY25236A patent/UY25236A1/es not_active IP Right Cessation
- 1998-11-06 NZ NZ504065A patent/NZ504065A/en unknown
- 1998-11-06 EP EP98952580A patent/EP1044202B1/en not_active Expired - Lifetime
- 1998-11-06 CN CN98810910A patent/CN1105115C/zh not_active Expired - Fee Related
- 1998-11-06 JP JP2000520446A patent/JP3605358B2/ja not_active Expired - Fee Related
- 1998-11-06 SK SK646-2000A patent/SK285245B6/sk not_active IP Right Cessation
- 1998-11-06 AU AU10226/99A patent/AU749094B2/en not_active Ceased
- 1998-11-06 EA EA200000502A patent/EA002092B1/ru not_active IP Right Cessation
-
2000
- 2000-04-18 IS IS5460A patent/IS2342B/is unknown
- 2000-04-27 NO NO20002188A patent/NO325920B1/no not_active IP Right Cessation
- 2000-05-04 HR HR20000261A patent/HRP20000261B1/xx not_active IP Right Cessation
- 2000-05-29 BG BG104485A patent/BG64906B1/bg unknown
-
2001
- 2001-06-28 HK HK01104490A patent/HK1034075A1/xx not_active IP Right Cessation
-
2002
- 2002-10-15 US US10/272,403 patent/US6844352B2/en not_active Expired - Fee Related
-
2004
- 2004-12-13 US US11/012,084 patent/US20050171135A1/en not_active Abandoned
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