DE69828999D1 - 1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)-spiro-(isobenzofuran-1(3h),4'-piperidin)-hydrohalogenide - Google Patents

1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)-spiro-(isobenzofuran-1(3h),4'-piperidin)-hydrohalogenide

Info

Publication number
DE69828999D1
DE69828999D1 DE69828999T DE69828999T DE69828999D1 DE 69828999 D1 DE69828999 D1 DE 69828999D1 DE 69828999 T DE69828999 T DE 69828999T DE 69828999 T DE69828999 T DE 69828999T DE 69828999 D1 DE69828999 D1 DE 69828999D1
Authority
DE
Germany
Prior art keywords
hydrohalogenide
isobenzofuran
indol
spiro
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69828999T
Other languages
English (en)
Other versions
DE69828999T2 (de
Inventor
Niels Mork
De Diego Heidi Lopez
Ole Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE69828999D1 publication Critical patent/DE69828999D1/de
Application granted granted Critical
Publication of DE69828999T2 publication Critical patent/DE69828999T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69828999T 1997-11-07 1998-11-06 1-(4-(1-(4-fluorophenyl)-1h-indol-3-yl)1-butyl)-spiro-(isobenzofuran-1(3h),4'-pperidin)-hydrohalogenide Expired - Fee Related DE69828999T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK126797 1997-11-07
DK126797 1997-11-07
PCT/DK1998/000480 WO1999024436A1 (en) 1997-11-07 1998-11-06 1'-[4-[1- (4-fluorophenyl)- 1h-indole-3-yl] -1-butyl]-spiro [isobenzofuran- 1(3h),4'- piperidine] hydrohalogenides

Publications (2)

Publication Number Publication Date
DE69828999D1 true DE69828999D1 (de) 2005-03-17
DE69828999T2 DE69828999T2 (de) 2005-07-21

Family

ID=8102935

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828999T Expired - Fee Related DE69828999T2 (de) 1997-11-07 1998-11-06 1-(4-(1-(4-fluorophenyl)-1h-indol-3-yl)1-butyl)-spiro-(isobenzofuran-1(3h),4'-pperidin)-hydrohalogenide

Country Status (39)

Country Link
US (2) US6844352B2 (de)
EP (1) EP1044202B1 (de)
JP (1) JP3605358B2 (de)
KR (1) KR100399274B1 (de)
CN (1) CN1105115C (de)
AR (1) AR023010A1 (de)
AT (1) ATE288918T1 (de)
AU (1) AU749094B2 (de)
BG (1) BG64906B1 (de)
BR (1) BR9813949A (de)
CA (1) CA2308745C (de)
CZ (1) CZ288666B6 (de)
DE (1) DE69828999T2 (de)
DZ (1) DZ2642A1 (de)
EA (1) EA002092B1 (de)
EG (1) EG23791A (de)
ES (1) ES2234162T3 (de)
HK (1) HK1034075A1 (de)
HR (1) HRP20000261B1 (de)
HU (1) HUP0100991A3 (de)
ID (1) ID25776A (de)
IL (1) IL135723A (de)
IS (1) IS2342B (de)
JO (1) JO2052B1 (de)
MA (1) MA25585A1 (de)
NO (1) NO325920B1 (de)
NZ (1) NZ504065A (de)
PE (1) PE130299A1 (de)
PL (1) PL190538B1 (de)
PT (1) PT1044202E (de)
RS (1) RS49777B (de)
SK (1) SK285245B6 (de)
TN (1) TNSN98201A1 (de)
TR (1) TR200001267T2 (de)
TW (1) TW483894B (de)
UA (1) UA64769C2 (de)
UY (1) UY25236A1 (de)
WO (1) WO1999024436A1 (de)
ZA (1) ZA9810116B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013789A1 (en) * 2000-08-15 2002-02-21 H. Lundbeck A/S Pharmaceutical composition containing 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl] -1-butyl]-spiro[isobenzofuran-1(3h),4'-piperidine]
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
WO2004110389A2 (en) * 2003-06-12 2004-12-23 Agy Therapeutics, Inc. Sigma ligands for neuronal regeneration and functional recovery
DE112006002660A5 (de) * 2005-07-29 2008-07-10 Sigma-Aldrich Production Gmbh Ionisierungsadditive enthaltende LC/MS-Blends
EP2377530A3 (de) 2005-10-21 2012-06-20 Braincells, Inc. Modulation von Neurogenese durch PDE-Hemmung
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
AU2007223036A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (de) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
BRPI0716604A2 (pt) * 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20080103165A1 (en) * 2006-09-19 2008-05-01 Braincells, Inc. Ppar mediated modulation of neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
IL135723A0 (en) 2001-05-20
EP1044202B1 (de) 2005-02-09
AU1022699A (en) 1999-05-31
ID25776A (id) 2000-11-02
TW483894B (en) 2002-04-21
TNSN98201A1 (fr) 2005-03-15
KR20010031791A (ko) 2001-04-16
TR200001267T2 (tr) 2000-09-21
EA200000502A1 (ru) 2000-10-30
ZA9810116B (en) 1999-05-07
UA64769C2 (uk) 2004-03-15
CA2308745A1 (en) 1999-05-20
HK1034075A1 (en) 2001-10-12
DZ2642A1 (fr) 2004-12-28
PE130299A1 (es) 1999-12-16
CZ20001663A3 (cs) 2000-10-11
PL190538B1 (pl) 2005-12-30
CN1105115C (zh) 2003-04-09
WO1999024436A1 (en) 1999-05-20
EG23791A (en) 2007-08-13
EP1044202A1 (de) 2000-10-18
KR100399274B1 (ko) 2003-09-26
IS5460A (is) 2000-04-18
AU749094B2 (en) 2002-06-20
NO20002188D0 (no) 2000-04-27
EA002092B1 (ru) 2001-12-24
HUP0100991A2 (hu) 2001-09-28
AR023010A1 (es) 2002-09-04
PL340220A1 (en) 2001-01-15
RS49777B (sr) 2008-06-05
BR9813949A (pt) 2000-09-26
NZ504065A (en) 2002-05-31
SK285245B6 (sk) 2006-09-07
BG64906B1 (bg) 2006-08-31
CN1278823A (zh) 2001-01-03
DE69828999T2 (de) 2005-07-21
SK6462000A3 (en) 2000-10-09
IL135723A (en) 2005-11-20
NO20002188L (no) 2000-06-14
JP3605358B2 (ja) 2004-12-22
BG104485A (en) 2001-01-31
HRP20000261A2 (en) 2001-04-30
JP2001522852A (ja) 2001-11-20
JO2052B1 (en) 1999-05-15
ES2234162T3 (es) 2005-06-16
MA25585A1 (fr) 2002-12-31
PT1044202E (pt) 2005-04-29
HUP0100991A3 (en) 2003-03-28
HRP20000261B1 (en) 2009-04-30
CZ288666B6 (cs) 2001-08-15
ATE288918T1 (de) 2005-02-15
UY25236A1 (es) 2000-12-29
IS2342B (is) 2008-02-15
US20030055074A1 (en) 2003-03-20
US20050171135A1 (en) 2005-08-04
NO325920B1 (no) 2008-08-18
US6844352B2 (en) 2005-01-18
YU23500A (sh) 2003-12-31
CA2308745C (en) 2004-01-20

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Legal Events

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8339 Ceased/non-payment of the annual fee