EA200000502A1 - 1'[4-[1-(4-фторфенил)-1h-индол-3-ил]-1-бутил]-спиро[изобензофуран-1(3h),4'- пиперидин] гидрогалогениды - Google Patents

1'[4-[1-(4-фторфенил)-1h-индол-3-ил]-1-бутил]-спиро[изобензофуран-1(3h),4'- пиперидин] гидрогалогениды

Info

Publication number
EA200000502A1
EA200000502A1 EA200000502A EA200000502A EA200000502A1 EA 200000502 A1 EA200000502 A1 EA 200000502A1 EA 200000502 A EA200000502 A EA 200000502A EA 200000502 A EA200000502 A EA 200000502A EA 200000502 A1 EA200000502 A1 EA 200000502A1
Authority
EA
Eurasian Patent Office
Prior art keywords
isobenzofuran
spiro
butyl
indol
piperidin
Prior art date
Application number
EA200000502A
Other languages
English (en)
Other versions
EA002092B1 (ru
Inventor
Нильс Мерк
Эйди Лопес Де Диего
Оле Нильсен
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200000502A1 publication Critical patent/EA200000502A1/ru
Publication of EA002092B1 publication Critical patent/EA002092B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к гидрогалогениду 1'-[4-[1-(4-фторфенил)-1H-индол-3-ил]-1-бутил]-спиро[изобензофуран-1(3H),4'-пиперидина], фармацевтическим композициям, содержащим эти кислотно-аддитивные соли, и применению их для лечения психических и неврологических нарушений.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000502A 1997-11-07 1998-11-06 Гидрогалогениды 1'[4-[1-(4-фторфенил)-1н-индол-3-ил]-1-бутил]-спиро[изобензофуран-1(3н),4'- пиперидина] EA002092B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK126797 1997-11-07
PCT/DK1998/000480 WO1999024436A1 (en) 1997-11-07 1998-11-06 1'-[4-[1- (4-fluorophenyl)- 1h-indole-3-yl] -1-butyl]-spiro [isobenzofuran- 1(3h),4'- piperidine] hydrohalogenides

Publications (2)

Publication Number Publication Date
EA200000502A1 true EA200000502A1 (ru) 2000-10-30
EA002092B1 EA002092B1 (ru) 2001-12-24

Family

ID=8102935

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000502A EA002092B1 (ru) 1997-11-07 1998-11-06 Гидрогалогениды 1'[4-[1-(4-фторфенил)-1н-индол-3-ил]-1-бутил]-спиро[изобензофуран-1(3н),4'- пиперидина]

Country Status (39)

Country Link
US (2) US6844352B2 (ru)
EP (1) EP1044202B1 (ru)
JP (1) JP3605358B2 (ru)
KR (1) KR100399274B1 (ru)
CN (1) CN1105115C (ru)
AR (1) AR023010A1 (ru)
AT (1) ATE288918T1 (ru)
AU (1) AU749094B2 (ru)
BG (1) BG64906B1 (ru)
BR (1) BR9813949A (ru)
CA (1) CA2308745C (ru)
CZ (1) CZ288666B6 (ru)
DE (1) DE69828999T2 (ru)
DZ (1) DZ2642A1 (ru)
EA (1) EA002092B1 (ru)
EG (1) EG23791A (ru)
ES (1) ES2234162T3 (ru)
HK (1) HK1034075A1 (ru)
HR (1) HRP20000261B1 (ru)
HU (1) HUP0100991A3 (ru)
ID (1) ID25776A (ru)
IL (1) IL135723A (ru)
IS (1) IS2342B (ru)
JO (1) JO2052B1 (ru)
MA (1) MA25585A1 (ru)
NO (1) NO325920B1 (ru)
NZ (1) NZ504065A (ru)
PE (1) PE130299A1 (ru)
PL (1) PL190538B1 (ru)
PT (1) PT1044202E (ru)
RS (1) RS49777B (ru)
SK (1) SK285245B6 (ru)
TN (1) TNSN98201A1 (ru)
TR (1) TR200001267T2 (ru)
TW (1) TW483894B (ru)
UA (1) UA64769C2 (ru)
UY (1) UY25236A1 (ru)
WO (1) WO1999024436A1 (ru)
ZA (1) ZA9810116B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013789A1 (en) * 2000-08-15 2002-02-21 H. Lundbeck A/S Pharmaceutical composition containing 1'-[4-[1-(4-fluorophenyl)-1h-indole-3-yl] -1-butyl]-spiro[isobenzofuran-1(3h),4'-piperidine]
WO2004026855A1 (en) * 2002-09-20 2004-04-01 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
EP1644026A4 (en) 2003-06-12 2007-10-24 Ms Science Corp SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECREATION
WO2007012319A1 (de) * 2005-07-29 2007-02-01 Sigma-Aldrich Production Gmbh Ionisierungsadditive enthaltende lc/ms-blends
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
WO2007104035A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) * 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2009002496A (es) * 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2066355A2 (en) * 2006-09-19 2009-06-10 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
CZ20001663A3 (cs) 2000-10-11
SK6462000A3 (en) 2000-10-09
CA2308745C (en) 2004-01-20
ID25776A (id) 2000-11-02
SK285245B6 (sk) 2006-09-07
IS5460A (is) 2000-04-18
PE130299A1 (es) 1999-12-16
HUP0100991A3 (en) 2003-03-28
HK1034075A1 (en) 2001-10-12
AU1022699A (en) 1999-05-31
CN1105115C (zh) 2003-04-09
YU23500A (sh) 2003-12-31
CA2308745A1 (en) 1999-05-20
CZ288666B6 (cs) 2001-08-15
JO2052B1 (en) 1999-05-15
UY25236A1 (es) 2000-12-29
PT1044202E (pt) 2005-04-29
EP1044202B1 (en) 2005-02-09
AR023010A1 (es) 2002-09-04
ES2234162T3 (es) 2005-06-16
BG64906B1 (bg) 2006-08-31
TNSN98201A1 (fr) 2005-03-15
KR100399274B1 (ko) 2003-09-26
ATE288918T1 (de) 2005-02-15
PL190538B1 (pl) 2005-12-30
EG23791A (en) 2007-08-13
BG104485A (en) 2001-01-31
US6844352B2 (en) 2005-01-18
JP3605358B2 (ja) 2004-12-22
CN1278823A (zh) 2001-01-03
UA64769C2 (ru) 2004-03-15
AU749094B2 (en) 2002-06-20
EA002092B1 (ru) 2001-12-24
DE69828999T2 (de) 2005-07-21
EP1044202A1 (en) 2000-10-18
NO20002188L (no) 2000-06-14
HUP0100991A2 (hu) 2001-09-28
TR200001267T2 (tr) 2000-09-21
IL135723A (en) 2005-11-20
HRP20000261B1 (en) 2009-04-30
BR9813949A (pt) 2000-09-26
DZ2642A1 (fr) 2004-12-28
US20030055074A1 (en) 2003-03-20
IL135723A0 (en) 2001-05-20
NZ504065A (en) 2002-05-31
WO1999024436A1 (en) 1999-05-20
US20050171135A1 (en) 2005-08-04
HRP20000261A2 (en) 2001-04-30
TW483894B (en) 2002-04-21
RS49777B (sr) 2008-06-05
MA25585A1 (fr) 2002-12-31
NO20002188D0 (no) 2000-04-27
ZA9810116B (en) 1999-05-07
IS2342B (is) 2008-02-15
JP2001522852A (ja) 2001-11-20
DE69828999D1 (de) 2005-03-17
NO325920B1 (no) 2008-08-18
PL340220A1 (en) 2001-01-15
KR20010031791A (ko) 2001-04-16

Similar Documents

Publication Publication Date Title
EA200000502A1 (ru) 1'[4-[1-(4-фторфенил)-1h-индол-3-ил]-1-бутил]-спиро[изобензофуран-1(3h),4'- пиперидин] гидрогалогениды
AU6329794A (en) Nitrogen-containing spirocycles
ES2097448T3 (es) Sulfitos y sulfatos ciclicos de fructopiranosis con actividad anticonvulsiva.
DE3887614T2 (de) Substituierte Cycloalkanole.
ES470155A1 (es) Un procedimiento para la obtencion de derivados de espiroa- mina
FI942499A0 (fi) Indolijohdannainen, menetelmä sen valmistamiseksi ja sen lääkekäyttö
IE802135L (en) Pyrazolobenzodiazepines
ES8800225A1 (es) Un procedimiento para preparar derivados de azirino-pirrolo-indoldiona
AU670491C (en) Pharmaceutical for the treatment of skin disorders
PH24725A (en) 9-amino-1,4-ethano-1,2,3,4-tetrahydrocridine and pharmaceutical composition and their use as medicaments
ES2104272T3 (es) Derivados de ciatano y estimuladores de la produccion de factor de crecimiento nervioso y agentes antimicrobianos que los contienen.
ES2064533T3 (es) Acido(1,2,3,4-tetrahidro-9-acridinimino)-ciclohexanocarboxilico y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
ATE96429T1 (de) Antihypertensive sulfonanilide.
AU570143B2 (en) Method of increasing heme excretion from a mammal using tin protoporphyrin
SG49680A1 (en) Medicament for the inducement of cognition enhancement
DK451184A (da) 3-alkyl-7-halogen-2,3-dihydro-spiro(naphthalen-1(4h), 3'-pyrrolidin)-2',4,5'-trioner og farmaceutiske praeparater indeholdende disse
FI832959A (fi) Spiro/2h-1,4-benzodiazepin-3(5h)4'-piperidin och 3'-pyrrolidin/foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
ES2001646A6 (es) Un procedimiento para preparar derivados de espiro(benzofuran-2(3h),1'-cicloheptano.
ATE35982T1 (de) Azetidinderivate.
ES2072334T3 (es) Derivados de 4,5,5a,6-tetrahidro-3h-isoxazolo(5,4,3-kl)acridinas, un procedimiento para su preparacion y su uso como medicamentos.
SE8107833L (sv) Substituerade tetrahydro-1,2,4-oxadiazin-5-on-derivat med kramplosande verkan, sett for deras framstellning och farmaceutiska beredningar innehallandedem
TH43887A (th) 1'-[4-[1-(4-ฟลูโอโรฟีนิล)-1h-อินโดล-3-อิล]-1-บิวทิล]-สไปโร [ไอโซเบนโซฟูแรน-1(3h), 4'-ไพเพอริดีน]ไฮโดรฮาโลจีไนด์
DK162188A (da) Fremgangsmaade til fremstilling af pentandionderivater

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU