HRP20000108A2 - Tetrahydro gamma-carbolines - Google Patents

Tetrahydro gamma-carbolines

Info

Publication number
HRP20000108A2
HRP20000108A2 HR20000108A HRP20000108A HRP20000108A2 HR P20000108 A2 HRP20000108 A2 HR P20000108A2 HR 20000108 A HR20000108 A HR 20000108A HR P20000108 A HRP20000108 A HR P20000108A HR P20000108 A2 HRP20000108 A2 HR P20000108A2
Authority
HR
Croatia
Prior art keywords
optionally substituted
6alkyl
aryl
carbolines
tetrahydro
Prior art date
Application number
HR20000108A
Other languages
English (en)
Inventor
Ludo Edmund Josephine Kennis
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20000108A2 publication Critical patent/HRP20000108A2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20000108A 1997-09-08 1998-09-01 Tetrahydro gamma-carbolines HRP20000108A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202761A EP0905136A1 (en) 1997-09-08 1997-09-08 Tetrahydro gamma-carbolines
PCT/EP1998/005710 WO1999012926A1 (en) 1997-09-08 1998-09-01 Tetrahydro gamma-carbolines

Publications (1)

Publication Number Publication Date
HRP20000108A2 true HRP20000108A2 (en) 2000-12-31

Family

ID=8228715

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000108A HRP20000108A2 (en) 1997-09-08 1998-09-01 Tetrahydro gamma-carbolines

Country Status (27)

Country Link
US (2) US6303614B1 (cs)
EP (2) EP0905136A1 (cs)
JP (1) JP2001515899A (cs)
KR (1) KR100603896B1 (cs)
CN (1) CN1110496C (cs)
AT (1) ATE243209T1 (cs)
AU (1) AU752410B2 (cs)
BR (1) BR9811769A (cs)
CA (1) CA2301807A1 (cs)
CZ (1) CZ297220B6 (cs)
DE (1) DE69815700T2 (cs)
EE (1) EE04496B1 (cs)
ES (1) ES2202902T3 (cs)
HR (1) HRP20000108A2 (cs)
HU (1) HUP0003577A3 (cs)
ID (1) ID23954A (cs)
IL (1) IL134894A (cs)
MY (1) MY129176A (cs)
NO (1) NO315236B1 (cs)
NZ (1) NZ503096A (cs)
PL (1) PL191863B1 (cs)
RU (1) RU2208614C2 (cs)
SK (1) SK285594B6 (cs)
TR (1) TR200000616T2 (cs)
TW (1) TW531539B (cs)
WO (1) WO1999012926A1 (cs)
ZA (1) ZA988161B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103788089A (zh) * 2003-09-17 2014-05-14 詹森药业有限公司 作为血清素受体调节剂的稠合杂环化合物
CA2782783C (en) * 2003-09-17 2018-03-27 Janssen Pharmaceutical, N.V. Fused heterocyclic compounds
EP1944306A1 (en) * 2003-09-17 2008-07-16 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds as serotonin receptor modulators
US7601734B2 (en) 2004-04-12 2009-10-13 Taisho Pharmaceutical Co., Ltd. Cyclic amine compound
PA8663501A1 (es) 2005-02-17 2006-11-09 Wyeth Wyeth Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados
FR2885905A1 (fr) * 2005-05-23 2006-11-24 Trophos Sa Nouveaux composes chimiques et leurs utilisations comme medicament
WO2007009485A1 (en) * 2005-07-22 2007-01-25 Pharma C S.A. Substituted 8-phenoxy-y-carboline derivatives with 5ht1 activity
JP2009515949A (ja) * 2005-11-15 2009-04-16 アストラゼネカ・アクチエボラーグ 新規な2−アミノピリミジノン誘導体およびそれらの使用
US7637410B2 (en) * 2006-10-06 2009-12-29 Tyco Healthcare Group Lp Surgical instrument including a locking assembly
US20090221627A1 (en) * 2007-09-20 2009-09-03 Alexey Aksinenko Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
RU2374245C1 (ru) 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
CN105399674B (zh) 2015-12-31 2017-02-15 青岛清原化合物有限公司 吡唑类化合物或其盐、制备方法、除草剂组合物及用途
CN106631941B (zh) * 2016-12-30 2018-09-28 青岛瀚生生物科技股份有限公司 一种2-甲基-3氯苯基甲硫醚的制备方法
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds
CN110698474B (zh) * 2019-11-14 2021-11-02 福州大学 一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用
MX2023004102A (es) * 2020-10-09 2023-04-27 Shujing Biopharma Co Ltd Derivado de gamma-carbolina fusionado sustituido con heterociclo, metodo de preparacion del mismo, intermediarios del mismo y uso del mismo.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
RU2067980C1 (ru) * 1992-06-30 1996-10-20 Глэксо Груп Лимитед Производные лактама и фармацевтическая композиция, являющаяся антагонистом 5-окситраптамина /5-нт/ на 5- нт3 -рецепторах или их физиологически приемлемые соли и соловаты
DE69531476T2 (de) * 1994-09-12 2004-06-09 Lilly Industries Ltd., Basingstoke Serotonergische Modulatoren

Also Published As

Publication number Publication date
NO20000737D0 (no) 2000-02-14
EE200000059A (et) 2000-10-16
EP1015451B1 (en) 2003-06-18
US6303614B1 (en) 2001-10-16
AU9742198A (en) 1999-03-29
IL134894A0 (en) 2001-05-20
WO1999012926A1 (en) 1999-03-18
US6506768B2 (en) 2003-01-14
PL339143A1 (en) 2000-12-04
DE69815700D1 (en) 2003-07-24
EP1015451A1 (en) 2000-07-05
MY129176A (en) 2007-03-30
CZ2000726A3 (cs) 2000-07-12
AU752410B2 (en) 2002-09-19
BR9811769A (pt) 2000-08-29
TR200000616T2 (tr) 2000-07-21
NO315236B1 (no) 2003-08-04
CA2301807A1 (en) 1999-03-18
EE04496B1 (et) 2005-06-15
DE69815700T2 (de) 2004-04-29
NO20000737L (no) 2000-05-08
HK1029107A1 (en) 2001-03-23
PL191863B1 (pl) 2006-07-31
TW531539B (en) 2003-05-11
RU2208614C2 (ru) 2003-07-20
IL134894A (en) 2005-03-20
NZ503096A (en) 2001-11-30
EP0905136A1 (en) 1999-03-31
CN1269800A (zh) 2000-10-11
KR20010022391A (ko) 2001-03-15
HUP0003577A2 (hu) 2001-09-28
JP2001515899A (ja) 2001-09-25
ES2202902T3 (es) 2004-04-01
CZ297220B6 (cs) 2006-10-11
US20020103209A1 (en) 2002-08-01
ZA988161B (en) 2000-03-22
SK2992000A3 (en) 2001-03-12
HUP0003577A3 (en) 2003-05-28
ID23954A (id) 2000-06-08
SK285594B6 (sk) 2007-04-05
ATE243209T1 (de) 2003-07-15
CN1110496C (zh) 2003-06-04
KR100603896B1 (ko) 2006-07-25

Similar Documents

Publication Publication Date Title
DE69815700D1 (en) Tetrahydro gamma-carboline
PH23607A (en) Amide derivatives and pharmaceutical composition containing said compounds
ZW290A1 (en) 2-aminopyrimidinone derivatives
HU896723D0 (en) Process for preparation of guanidine-derivatives and insecticid compositions comprising these compounds as active ingredient
NL300298I1 (nl) Nieuwe 3-piperidinyl-1,2-benzisoxazolen
DK1029853T3 (da) Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
MXPA03011244A (es) Nuevos derivados de indol con afinidad por el receptor 5-ht6.
HU9401974D0 (en) New intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them
EP0324387A3 (en) Composition for treatment of ischemic disorder in organs
NZ214156A (en) Quindone derivatives and pharmaceutical compositions
IL114785A0 (en) Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
EP0430201A3 (en) Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
EP0604354A3 (en) Antidepressant and anti-Parkinson's disease compounds.
MY125562A (en) Hexahydro-pyrido (4,3-b) indole derivatives as antipsychotic drugs
PT91613A (pt) Process for the preparation of antihypertensive 3-piperidinyl-indazole derivatives
BG105521A (en) Benzisoxazoles and phenons as alpha2-antagonists
TW275629B (cs)

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20060807

Year of fee payment: 9

OBST Application withdrawn