HK54294A - Process for synthesis of aminomethylene phosphonoalkylphosphinates - Google Patents
Process for synthesis of aminomethylene phosphonoalkylphosphinatesInfo
- Publication number
- HK54294A HK54294A HK54294A HK54294A HK54294A HK 54294 A HK54294 A HK 54294A HK 54294 A HK54294 A HK 54294A HK 54294 A HK54294 A HK 54294A HK 54294 A HK54294 A HK 54294A
- Authority
- HK
- Hong Kong
- Prior art keywords
- aminomethylene
- phosphonoalkylphosphinates
- synthesis
- ester
- mixture
- Prior art date
Links
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- -1 alkyl phosphite Chemical compound 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/069,663 US4963681A (en) | 1987-07-06 | 1987-07-06 | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK54294A true HK54294A (en) | 1994-06-03 |
Family
ID=22090440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK54294A HK54294A (en) | 1987-07-06 | 1994-05-24 | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4963681A (fr) |
| EP (1) | EP0298555B1 (fr) |
| JP (1) | JPS6485985A (fr) |
| KR (1) | KR960008094B1 (fr) |
| AT (1) | ATE67500T1 (fr) |
| AU (1) | AU607781B2 (fr) |
| CA (1) | CA1322077C (fr) |
| DE (1) | DE3864927D1 (fr) |
| DK (1) | DK375688A (fr) |
| EG (1) | EG18559A (fr) |
| ES (1) | ES2029875T3 (fr) |
| FI (1) | FI88721C (fr) |
| GR (1) | GR3002741T3 (fr) |
| HK (1) | HK54294A (fr) |
| IE (1) | IE60912B1 (fr) |
| IL (1) | IL86952A (fr) |
| MX (1) | MX171302B (fr) |
| MY (1) | MY106953A (fr) |
| NO (1) | NO176479C (fr) |
| NZ (1) | NZ225273A (fr) |
| PH (1) | PH25817A (fr) |
| PT (1) | PT87916B (fr) |
| ZA (1) | ZA884793B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8825589D0 (en) * | 1988-11-02 | 1988-12-07 | Albright & Wilson | Purification |
| US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
| DK0531253T3 (da) * | 1991-08-27 | 1997-01-27 | Ciba Geigy Ag | N-substituerede aminomethandiphosphonsyrer |
| US5278153A (en) * | 1992-05-18 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method |
| JP5150911B2 (ja) | 2007-11-27 | 2013-02-27 | ハリマ化成株式会社 | はんだ付け用フラックスおよびはんだペースト組成物 |
| EP2221140B1 (fr) | 2007-11-27 | 2013-09-25 | Harima Chemicals, Inc. | Flux de brasage tendre, composition à braser et procédé de brasage associé |
| GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3553314A (en) * | 1968-12-23 | 1971-01-05 | Procter & Gamble | Oral compositions for calculus retardation |
| US3979385A (en) * | 1969-11-19 | 1976-09-07 | Henkel & Cie G.M.B.H. | 1-Aminoalkane-1,1-diphosphonic acids and their salts |
| DE1958123C3 (de) * | 1969-11-19 | 1978-09-28 | Henkel Kgaa, 4000 Duesseldorf | Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen |
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| US3899496A (en) * | 1970-10-06 | 1975-08-12 | Henkel & Cie Gmbh | Production of 1-aminoalkane-1,1-diphosphonic acids |
| DE2104476C2 (de) * | 1971-02-01 | 1983-12-01 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Verhinderung von Ausfällungen in Wasser oder wäßrigen Lösungen |
| US3988443A (en) * | 1973-08-27 | 1976-10-26 | Henkel & Cie G.M.B.H. | Azacycloalkane-2,2-diphosphonic acids |
| DE2343196C3 (de) * | 1973-08-27 | 1980-01-10 | Henkel Kgaa, 4000 Duesseldorf | Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze |
| DE2360798A1 (de) * | 1973-12-06 | 1975-06-26 | Henkel & Cie Gmbh | Pharmazeutische oder kosmetische praeparate |
| US4134969A (en) * | 1974-02-04 | 1979-01-16 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Method of treatment of calcium disorders using aminoalkane-diphosphonic acids |
| DE2456666A1 (de) * | 1974-11-30 | 1976-08-12 | Henkel & Cie Gmbh | Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse |
| US4113861A (en) * | 1977-05-02 | 1978-09-12 | The Procter & Gamble Company | Phosphonate pharmaceutical composition |
| DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| IL61985A0 (en) * | 1980-02-01 | 1981-02-27 | Sparamedica Ag | Phosphinic and phosphonic acid derivatives,their manufacture and pharmaceutical compositions containing them |
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| DE3425812A1 (de) * | 1984-07-13 | 1986-01-16 | Deutsches Krebsforschungszentrum, 6900 Heidelberg | Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4639338A (en) * | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
| US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| US4871721A (en) * | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
-
1987
- 1987-07-06 US US07/069,663 patent/US4963681A/en not_active Expired - Fee Related
-
1988
- 1988-07-01 IL IL86952A patent/IL86952A/xx not_active IP Right Cessation
- 1988-07-04 ES ES198888201388T patent/ES2029875T3/es not_active Expired - Lifetime
- 1988-07-04 DE DE8888201388T patent/DE3864927D1/de not_active Expired - Fee Related
- 1988-07-04 AT AT88201388T patent/ATE67500T1/de not_active IP Right Cessation
- 1988-07-04 NZ NZ225273A patent/NZ225273A/en unknown
- 1988-07-04 EP EP88201388A patent/EP0298555B1/fr not_active Expired - Lifetime
- 1988-07-05 ZA ZA884793A patent/ZA884793B/xx unknown
- 1988-07-05 CA CA000571159A patent/CA1322077C/fr not_active Expired - Fee Related
- 1988-07-05 PH PH37177A patent/PH25817A/en unknown
- 1988-07-05 IE IE205188A patent/IE60912B1/en not_active IP Right Cessation
- 1988-07-05 PT PT87916A patent/PT87916B/pt not_active IP Right Cessation
- 1988-07-05 NO NO882986A patent/NO176479C/no not_active IP Right Cessation
- 1988-07-05 FI FI883207A patent/FI88721C/fi not_active IP Right Cessation
- 1988-07-06 JP JP63168629A patent/JPS6485985A/ja active Pending
- 1988-07-06 DK DK375688A patent/DK375688A/da not_active Application Discontinuation
- 1988-07-06 EG EG375/88A patent/EG18559A/xx active
- 1988-07-06 AU AU18766/88A patent/AU607781B2/en not_active Ceased
- 1988-07-06 KR KR1019880008336A patent/KR960008094B1/ko not_active IP Right Cessation
- 1988-07-06 MY MYPI88000747A patent/MY106953A/en unknown
- 1988-07-07 MX MX012196A patent/MX171302B/es unknown
-
1991
- 1991-09-19 GR GR91400446T patent/GR3002741T3/el unknown
-
1994
- 1994-05-24 HK HK54294A patent/HK54294A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6485985A (en) | 1989-03-30 |
| EP0298555A1 (fr) | 1989-01-11 |
| EG18559A (en) | 1993-06-30 |
| DK375688D0 (da) | 1988-07-06 |
| DE3864927D1 (de) | 1991-10-24 |
| ZA884793B (en) | 1989-03-29 |
| IL86952A0 (en) | 1988-12-30 |
| DK375688A (da) | 1989-01-07 |
| FI88721B (fi) | 1993-03-15 |
| NO176479B (no) | 1995-01-02 |
| MX171302B (es) | 1993-10-18 |
| FI88721C (fi) | 1993-06-28 |
| IE60912B1 (en) | 1994-08-24 |
| ATE67500T1 (de) | 1991-10-15 |
| NZ225273A (en) | 1991-07-26 |
| KR960008094B1 (ko) | 1996-06-19 |
| FI883207A (fi) | 1989-01-07 |
| AU1876688A (en) | 1989-01-12 |
| IE882051L (en) | 1989-01-06 |
| AU607781B2 (en) | 1991-03-14 |
| IL86952A (en) | 1993-01-14 |
| US4963681A (en) | 1990-10-16 |
| GR3002741T3 (en) | 1993-01-25 |
| NO176479C (no) | 1995-04-12 |
| NO882986L (no) | 1989-01-09 |
| ES2029875T3 (es) | 1992-10-01 |
| PH25817A (en) | 1991-11-05 |
| MY106953A (en) | 1995-08-30 |
| NO882986D0 (no) | 1988-07-05 |
| EP0298555B1 (fr) | 1991-09-18 |
| FI883207A0 (fi) | 1988-07-05 |
| PT87916B (pt) | 1995-03-01 |
| CA1322077C (fr) | 1993-09-07 |
| PT87916A (pt) | 1989-06-30 |
| KR890002208A (ko) | 1989-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |