HK35796A - Improved 9-g(a)-dehalogenation process - Google Patents
Improved 9-g(a)-dehalogenation processInfo
- Publication number
- HK35796A HK35796A HK35796A HK35796A HK35796A HK 35796 A HK35796 A HK 35796A HK 35796 A HK35796 A HK 35796A HK 35796 A HK35796 A HK 35796A HK 35796 A HK35796 A HK 35796A
- Authority
- HK
- Hong Kong
- Prior art keywords
- chromium
- improved
- alpha
- image
- dehalogenation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8590787A | 1987-08-14 | 1987-08-14 | |
US9580387A | 1987-09-11 | 1987-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK35796A true HK35796A (en) | 1996-03-08 |
Family
ID=26773223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK35796A HK35796A (en) | 1987-08-14 | 1996-02-29 | Improved 9-g(a)-dehalogenation process |
Country Status (9)
Country | Link |
---|---|
US (1) | US5426198A (xx) |
EP (1) | EP0374185B1 (xx) |
JP (1) | JP2604842B2 (xx) |
KR (1) | KR970000046B1 (xx) |
AT (1) | ATE85620T1 (xx) |
AU (1) | AU2315488A (xx) |
DE (1) | DE3878463T2 (xx) |
HK (1) | HK35796A (xx) |
WO (1) | WO1989001482A1 (xx) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU203562B (en) * | 1989-03-09 | 1991-08-28 | Richter Gedeon Vegyeszet | Process for producing new steroide diols and pharmaceutical compositions containing them |
DK0614463T3 (da) * | 1991-11-22 | 2003-03-31 | Alcon Lab Inc | Angiostatiske steroider |
CN101397324B (zh) * | 2007-09-29 | 2012-08-08 | 天津药业研究院有限公司 | 泼尼松龙及其衍生物的制备 |
CN102746357A (zh) * | 2011-04-22 | 2012-10-24 | 天津金耀集团有限公司 | 一种还原甾体的合成工艺 |
CN102617686A (zh) * | 2012-03-16 | 2012-08-01 | 浙江凯迪药业有限公司 | 一种泼尼松的制备方法 |
CN103724384B (zh) * | 2012-10-10 | 2016-04-20 | 河南利华制药有限公司 | 一种醋酸可的松的制备方法 |
CN104610407B (zh) * | 2015-01-27 | 2016-08-17 | 湖南新合新生物医药有限公司 | 醋酸氢化可的松的精制方法 |
WO2016120891A1 (en) | 2015-01-30 | 2016-08-04 | Coral Drugs Pvt. Ltd. | Novel process for preparation of glucocorticoid steroids |
CN106866765B (zh) * | 2016-12-12 | 2019-01-15 | 河南利华制药有限公司 | 一种醋酸可的松的制备方法 |
CN107400153B (zh) * | 2017-04-23 | 2019-08-27 | 浙江仙琚制药股份有限公司 | 一种醋酸氢化可的松的制备方法 |
CN108059647B (zh) * | 2018-01-24 | 2020-10-20 | 重庆华邦胜凯制药有限公司 | 一种二丙酸阿氯米松中间体11-β羟基孕甾的合成方法 |
CN111018932B (zh) * | 2019-11-28 | 2021-07-02 | 奥锐特药业股份有限公司 | 一种甾体化合物9-位脱卤的方法 |
CN111253457B (zh) | 2020-03-20 | 2021-03-19 | 浙江神洲药业有限公司 | 一种制备16α-羟基泼尼松龙的方法 |
CN111518151B (zh) * | 2020-04-27 | 2021-03-02 | 浙江神洲药业有限公司 | 一种高纯度氢化可的松的制备方法 |
CN112375114A (zh) * | 2020-11-12 | 2021-02-19 | 湖南新合新生物医药有限公司 | 醋酸泼尼松龙的制备方法 |
CN114213494B (zh) * | 2022-01-06 | 2023-06-02 | 江苏远大仙乐药业有限公司 | 帕拉米松乙酸酯及帕拉米松的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL128202C (xx) * | 1964-01-21 | |||
US4304727A (en) * | 1980-12-05 | 1981-12-08 | The Upjohn Company | 9α-Debromination |
-
1988
- 1988-07-22 AT AT88908083T patent/ATE85620T1/de not_active IP Right Cessation
- 1988-07-22 AU AU23154/88A patent/AU2315488A/en not_active Abandoned
- 1988-07-22 EP EP88908083A patent/EP0374185B1/en not_active Expired - Lifetime
- 1988-07-22 WO PCT/US1988/002430 patent/WO1989001482A1/en active IP Right Grant
- 1988-07-22 KR KR1019890700643A patent/KR970000046B1/ko not_active IP Right Cessation
- 1988-07-22 JP JP63506991A patent/JP2604842B2/ja not_active Expired - Fee Related
- 1988-07-22 DE DE8888908083T patent/DE3878463T2/de not_active Expired - Fee Related
-
1990
- 1990-01-31 US US07/460,842 patent/US5426198A/en not_active Expired - Fee Related
-
1996
- 1996-02-29 HK HK35796A patent/HK35796A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0374185A1 (en) | 1990-06-27 |
AU2315488A (en) | 1989-03-09 |
ATE85620T1 (de) | 1993-02-15 |
EP0374185B1 (en) | 1993-02-10 |
DE3878463T2 (de) | 1993-06-24 |
JPH02504511A (ja) | 1990-12-20 |
DE3878463D1 (de) | 1993-03-25 |
WO1989001482A1 (en) | 1989-02-23 |
KR890701612A (ko) | 1989-12-21 |
US5426198A (en) | 1995-06-20 |
KR970000046B1 (ko) | 1997-01-04 |
JP2604842B2 (ja) | 1997-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20050722 |