HK3396A - Cloning and expression of bordetella pertussis toxin-encoding dna - Google Patents

Cloning and expression of bordetella pertussis toxin-encoding dna

Info

Publication number
HK3396A
HK3396A HK3396A HK3396A HK3396A HK 3396 A HK3396 A HK 3396A HK 3396 A HK3396 A HK 3396A HK 3396 A HK3396 A HK 3396A HK 3396 A HK3396 A HK 3396A
Authority
HK
Hong Kong
Prior art keywords
pertussis toxin
cloning
pertussis
expression
subunits
Prior art date
Application number
HK3396A
Other languages
English (en)
Inventor
Rino Rappuoli
Alfredo Nicosia
Maria Beatrice Arico
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT19208/86A external-priority patent/IT1191657B/it
Priority claimed from IT8621314A external-priority patent/IT1213313B/it
Application filed by Sclavo Spa filed Critical Sclavo Spa
Publication of HK3396A publication Critical patent/HK3396A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK3396A 1986-01-28 1996-01-04 Cloning and expression of bordetella pertussis toxin-encoding dna HK3396A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT19208/86A IT1191657B (it) 1986-01-28 1986-01-28 Clonaggio e sequenziamento del frammenti di dna che codifica per le cinque subunita' della tossina della pertosse,molecola di dna ricombinante contenente detto frammento di dna e microorganismi trasformati con detta molecola di dna ricombiante
IT8621314A IT1213313B (it) 1986-07-30 1986-07-30 Clonaggio e sequenziamento del frammento di dna che codifica per le cinque subunita' della tossina della pertosse, plasmide ibrido contenente detto frammento di dna e microorganismi trasformati con detto plasmide ibrido capaci di esprimere tutte o alcune delle subunita' della tossina della pertosse.

Publications (1)

Publication Number Publication Date
HK3396A true HK3396A (en) 1996-01-12

Family

ID=26327094

Family Applications (1)

Application Number Title Priority Date Filing Date
HK3396A HK3396A (en) 1986-01-28 1996-01-04 Cloning and expression of bordetella pertussis toxin-encoding dna

Country Status (8)

Country Link
US (3) US6350612B1 (xx)
EP (1) EP0232229B1 (xx)
JP (1) JP2685442B2 (xx)
AT (1) ATE107692T1 (xx)
CA (1) CA1340373C (xx)
DE (1) DE3750094T2 (xx)
ES (1) ES2054701T3 (xx)
HK (1) HK3396A (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380653A (en) * 1980-12-31 1995-01-10 The Finnish National Public Health Institute Expression vectors and methods for intracellular protein production in bascillus
SE455946B (sv) * 1986-10-20 1988-08-22 Trion Forskning & Utveckling Nya pertussistoxin-polypeptider och antigener samt testsatser, vacciner och intradermala hudtestkompositioner
AU616649B2 (en) * 1986-12-22 1991-11-07 Trion Forskning- Och Utvecklings Aktiebolag A new pertussis toxin derived polypeptide and applications thereof
ES2044959T3 (es) * 1986-12-23 1994-01-16 Univ Leland Stanford Junior Exotoxina de tos ferina modificada.
IT1202612B (it) * 1987-03-03 1989-02-09 Eniricerche Spa Plasmidi ricombinanti utili per l'espressione in bacillus di proteine eterologhe
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
IT1223334B (it) * 1987-11-02 1990-09-19 Sclavo Spa Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5244657A (en) * 1987-11-24 1993-09-14 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
IT1224254B (it) * 1988-04-08 1990-09-26 Sclavo Spa Sistema di regolazione positivo inducibile utile per la produzione di proteine eterologhe
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
WO1990009444A1 (en) * 1989-02-10 1990-08-23 Genesit Oy A method for producing pertussis toxin subunits
WO1990009448A1 (en) * 1989-02-10 1990-08-23 Genesit Oy Novel expression vectors and methods for intracellular protein production
ES2078258T3 (es) * 1989-04-28 1995-12-16 Sclavo Spa Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
JPH08501569A (ja) * 1992-10-02 1996-02-20 アルバータ リサーチ カウンスル 糖質結合ペプチドの抗炎症性、免疫寛容原性、および免疫阻害性
CA2118824A1 (en) * 1993-03-15 1994-09-16 Steven M. Baker Expression of pertussis holotoxin in bordetella pertussis
US5856122A (en) * 1993-08-24 1999-01-05 University Of Alberta Modification of pertussis toxin
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
WO1996037235A1 (en) * 1995-05-25 1996-11-28 Panther Scientific, Inc. Methods for inhibition of hiv
JP3737519B2 (ja) * 1996-05-31 2006-01-18 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 百日咳菌ワクチン用アジュバントとしてのｉｌ―１２
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
WO2002074244A2 (en) 2001-03-19 2002-09-26 Iomai Corporation Transcutaneous immunostimulation
EP1353407B1 (de) * 2002-04-12 2011-01-19 Weidmüller Interface GmbH & Co. KG Anschlussvorrichtung für Leiter
MY142815A (en) * 2004-02-19 2011-01-14 Univ Florida Use of molt-accelerating compounds, ecdysteroids, analogs thereof, and chitin synthesis inhibitors for controlling termites.
JPWO2005090576A1 (ja) * 2004-03-18 2008-02-07 財団法人ヒューマンサイエンス振興財団 百日咳感染症予防用ｄｎａ構築物
NZ602958A (en) * 2010-03-30 2014-07-25 Pfenex Inc High level expression of recombinant toxin proteins
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
WO2014044690A1 (en) 2012-09-18 2014-03-27 Valneva Austria Gmbh Improved vaccines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US843727A (en) * 1905-01-19 1907-02-12 Arthur E White Coffee-maker.
JPS6098988A (ja) * 1983-11-01 1985-06-01 Chemo Sero Therapeut Res Inst Ｌｐｆ−ｈａの精製法
FR2590483B1 (fr) * 1985-11-22 1988-12-09 Pasteur Institut Antigenes purifies ayant des proprietes vaccinantes contre b. pertussis, moyens notamment adns recombinants pour les produire et compositions de vaccins les contenant
ES2026259T3 (es) * 1987-12-16 1992-04-16 Imperial Chemical Industries Plc Metodo perfeccionado para fabricar plancha metalica compuesta, multilaminar, de union aglutinante por medio de explosivo.

Also Published As

Publication number Publication date
JP2685442B2 (ja) 1997-12-03
DE3750094T2 (de) 1994-10-20
EP0232229A3 (en) 1988-04-20
EP0232229B1 (en) 1994-06-22
JPS62228286A (ja) 1987-10-07
EP0232229A2 (en) 1987-08-12
US6350612B1 (en) 2002-02-26
ES2054701T3 (es) 1994-08-16
DE3750094D1 (de) 1994-07-28
US5785971A (en) 1998-07-28
CA1340373C (en) 1999-02-02
US5427788A (en) 1995-06-27
ATE107692T1 (de) 1994-07-15

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IT1213313B (it) Clonaggio e sequenziamento del frammento di dna che codifica per le cinque subunita' della tossina della pertosse, plasmide ibrido contenente detto frammento di dna e microorganismi trasformati con detto plasmide ibrido capaci di esprimere tutte o alcune delle subunita' della tossina della pertosse.
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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)