HK1256027A1 - 用於以輸注或注射形式進行靜脈給藥的左西孟旦以及輸注濃縮液的改善配方 - Google Patents

用於以輸注或注射形式進行靜脈給藥的左西孟旦以及輸注濃縮液的改善配方

Info

Publication number
HK1256027A1
HK1256027A1 HK18115077.4A HK18115077A HK1256027A1 HK 1256027 A1 HK1256027 A1 HK 1256027A1 HK 18115077 A HK18115077 A HK 18115077A HK 1256027 A1 HK1256027 A1 HK 1256027A1
Authority
HK
Hong Kong
Prior art keywords
infusion
levosimendan
injection
intravenous administration
concentrate
Prior art date
Application number
HK18115077.4A
Other languages
English (en)
Inventor
安德烈亞‧威蘭德
Original Assignee
卡利努法姆股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 卡利努法姆股份有限公司 filed Critical 卡利努法姆股份有限公司
Publication of HK1256027A1 publication Critical patent/HK1256027A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK18115077.4A 2015-11-06 2018-11-26 用於以輸注或注射形式進行靜脈給藥的左西孟旦以及輸注濃縮液的改善配方 HK1256027A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15193521 2015-11-06
PCT/EP2016/076669 WO2017077032A1 (en) 2015-11-06 2016-11-04 Improved formulations of levosimendan for intravenous administration as infusion or injection and of infusion concentrate

Publications (1)

Publication Number Publication Date
HK1256027A1 true HK1256027A1 (zh) 2019-09-13

Family

ID=54476869

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18115077.4A HK1256027A1 (zh) 2015-11-06 2018-11-26 用於以輸注或注射形式進行靜脈給藥的左西孟旦以及輸注濃縮液的改善配方

Country Status (22)

Country Link
US (1) US10507179B2 (zh)
EP (1) EP3370693B1 (zh)
JP (1) JP6770754B2 (zh)
KR (1) KR102656823B1 (zh)
CN (1) CN108289832B (zh)
AU (1) AU2016349408B2 (zh)
BR (1) BR112018009250B1 (zh)
CA (1) CA3004362C (zh)
CY (1) CY1122997T1 (zh)
DK (1) DK3370693T3 (zh)
EA (1) EA034565B1 (zh)
ES (1) ES2782106T3 (zh)
HK (1) HK1256027A1 (zh)
HR (1) HRP20200329T1 (zh)
HU (1) HUE048197T2 (zh)
LT (1) LT3370693T (zh)
ME (1) ME03761B (zh)
PL (1) PL3370693T3 (zh)
PT (1) PT3370693T (zh)
RS (1) RS60119B1 (zh)
SI (1) SI3370693T1 (zh)
WO (1) WO2017077032A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2678686C1 (ru) * 2017-09-18 2019-01-30 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации Способ подготовки малого круга кровообращения реципиентов перед выполнением трансплантации сердца
CA3110313A1 (en) 2018-08-21 2020-02-27 Tenax Therapeutics, Inc. Pharmaceutical compositions for subcutaneous administration of levosimendan
WO2020214510A1 (en) * 2019-04-16 2020-10-22 Kantum Pharma, Inc. Pharmaceutical formulations containing p2y14 antagonists
CN110742863B (zh) * 2019-11-22 2022-04-12 青海民族大学 一种槲皮素衍生物纳米胶束及其制备方法
EP4076398A4 (en) 2019-12-16 2024-01-03 Tenax Therapeutics, Inc. LEVOSIMENDAN TO TREAT PULMONARY HYPERTENSION ACCOMPANIED BY HEART FAILURE BY MEANS OF PRESERVED EJECTION FRACTION (PH-HF-PEF)
US20220016070A1 (en) * 2020-07-17 2022-01-20 Good Health, Llc Premixed, ready to use pharmaceutical compositions of amiodarone

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4207922A1 (de) * 1992-03-13 1993-09-23 Pharmatech Gmbh Wasserloesliche einschlussverbindungen und verfahren zu deren herstellung
JPH0848638A (ja) * 1994-08-05 1996-02-20 Makoto Otsuka 難溶性化合物の分子化合物および難溶性化合物の溶解性改善方法
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
JP2003063965A (ja) * 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
CN1470238A (zh) * 2003-06-18 2004-01-28 王景成 左西孟旦制剂及其制备方法
CN1611219A (zh) * 2003-10-30 2005-05-04 西安宏盛医药开发有限公司 左西孟旦药物组合物及其制备方法
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
CN1626085A (zh) * 2003-12-11 2005-06-15 济南百诺医药科技开发有限公司 左西孟旦冻干制剂及其制备方法
CN100367964C (zh) * 2004-04-29 2008-02-13 王思清 左西孟旦-β环糊精包含物制剂
CN1839842A (zh) * 2006-01-16 2006-10-04 成都英创科技发展有限责任公司 一种含左西孟旦或其药学上可以接受的盐作为活性成分的药物组合物
JP2008048638A (ja) * 2006-08-23 2008-03-06 Asahi Kasei Fibers Corp 乳牛乳房清拭用ワイパー
US20080104001A1 (en) * 2006-10-27 2008-05-01 Kipp James E Algorithm for estimation of binding equlibria in inclusion complexation, host compounds identified thereby and compositions of host compound and pharmaceutical
WO2008065142A1 (en) * 2006-11-29 2008-06-05 N.V. Organon Stabilized solution of rocuronium comprising a sulfoalkyl-ether-beta-cyclodextrin derivative
CN101305984A (zh) * 2007-05-16 2008-11-19 南京新港医药有限公司 一种药物溶液
CN101411708B (zh) * 2007-10-17 2010-12-22 齐鲁制药有限公司 稳定的左西孟旦药物组合物及其制备方法
CN102335118B (zh) * 2011-10-14 2012-10-17 济南康和医药科技有限公司 一种伏立康唑冻干胶束制剂及其制备方法

Also Published As

Publication number Publication date
KR102656823B1 (ko) 2024-04-16
AU2016349408B2 (en) 2021-06-03
JP6770754B2 (ja) 2020-10-21
EP3370693A1 (en) 2018-09-12
SI3370693T1 (sl) 2020-07-31
AU2016349408A1 (en) 2018-04-12
KR20180070667A (ko) 2018-06-26
HRP20200329T1 (hr) 2020-07-24
ES2782106T3 (es) 2020-09-10
CA3004362A1 (en) 2017-05-11
US10507179B2 (en) 2019-12-17
DK3370693T3 (da) 2020-03-23
LT3370693T (lt) 2020-04-10
HUE048197T2 (hu) 2020-07-28
ME03761B (me) 2021-01-20
JP2018535943A (ja) 2018-12-06
EA201890982A1 (ru) 2018-11-30
CY1122997T1 (el) 2021-10-29
BR112018009250A2 (pt) 2018-11-06
PL3370693T3 (pl) 2020-07-13
BR112018009250B1 (pt) 2023-12-05
EP3370693B1 (en) 2020-01-08
RS60119B1 (sr) 2020-05-29
WO2017077032A1 (en) 2017-05-11
US20180318210A1 (en) 2018-11-08
EA034565B1 (ru) 2020-02-20
CN108289832B (zh) 2021-08-31
CA3004362C (en) 2022-10-04
CN108289832A (zh) 2018-07-17
PT3370693T (pt) 2020-04-08

Similar Documents

Publication Publication Date Title
HK1256027A1 (zh) 用於以輸注或注射形式進行靜脈給藥的左西孟旦以及輸注濃縮液的改善配方
IL263670A (en) Assemblies and methods for infusion pump system delivery kits
EP3352814A4 (en) SUBCUTANEOUS INSULIN INFUSION CATHETER CONTINUES
IL262738A (en) Intravenous infusion set
PL3402480T3 (pl) Kompozycje i sposoby dożylnego podawania 2-bromo-1-(3,3-dinitroazetydyn-1-ylo)etanonu
HK1215205A1 (zh) 可拋式無導管藥物輸注系統
EP3256133A4 (en) Intravenous infusion dosage form
EP3275482A4 (en) Syringe holder and medical solution administration set
IL275282A (en) Infusion pump systems and methods for administration kits
IL257482A (en) Needleless syringe
HK1254855A1 (zh) 在手術期間給患者靜脈內施用瓜氨酸
HK1253523B (zh) 用於給予泡沫的注射器
EP3305347A4 (en) LIQUID INFUSION DEVICE FOR MEDICINE ADMINISTRATION TO A PATIENT
ZA201703764B (en) Formulations of a pi3k/mtor-inhibitor for intravenous administration
GB201518170D0 (en) Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent
EP3436108A4 (en) AUTOMATIC RINSING INTRAVENOUS INFUSION TUBE
ITUB20152060A1 (it) Porta-capsula e macchina per la preparazione di bevande infuse
PL3470045T3 (pl) Dożylna infuzyjna postać dawkowania dla pemetreksedu
HK1244680A1 (zh) 用於靜脈內施用反丁烯二酸酯以治療神經疾病的方法和組合物
GB201602754D0 (en) Extendible intravenous cannula
UA28501S (uk) Катетер внутрішньовенний з ін'єкційним портом
GB201403532D0 (en) Intravenous cannula