HK1255192A1 - 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 - Google Patents

表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 Download PDF

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Publication number
HK1255192A1
HK1255192A1 HK18114315.9A HK18114315A HK1255192A1 HK 1255192 A1 HK1255192 A1 HK 1255192A1 HK 18114315 A HK18114315 A HK 18114315A HK 1255192 A1 HK1255192 A1 HK 1255192A1
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Hong Kong
Prior art keywords
cytokine
boxylesterase
car
methods
oncolytic vaccinia
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HK18114315.9A
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English (en)
Chinese (zh)
Inventor
Tae Ho Hwang
Nam Hee Lee
Euna CHO
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Sillajen, Inc.
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Publication of HK1255192A1 publication Critical patent/HK1255192A1/zh

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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HK18114315.9A 2015-09-08 2016-09-02 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 HK1255192A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562215651P 2015-09-08 2015-09-08
US62/215,651 2015-09-08
PCT/KR2016/009866 WO2017043815A1 (en) 2015-09-08 2016-09-02 Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof

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Publication Number Publication Date
HK1255192A1 true HK1255192A1 (zh) 2019-08-09

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US (1) US10646524B2 (enExample)
EP (1) EP3347460A4 (enExample)
JP (1) JP6895968B2 (enExample)
KR (1) KR102674362B1 (enExample)
CN (1) CN108350434B (enExample)
AU (1) AU2016320355B2 (enExample)
CA (1) CA2996120C (enExample)
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WO (1) WO2017043815A1 (enExample)

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WO2016144564A2 (en) 2015-02-25 2016-09-15 Memorial Sloan-Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
CN107847534B (zh) 2015-04-17 2022-10-04 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
CA2990133A1 (en) * 2015-06-19 2017-03-09 Sillajen, Inc. Compositions and methods for viral embolization
IL261321B2 (en) 2016-02-25 2023-12-01 Memorial Sloan Kettering Cancer Center Recombinant MVA or MVADELE3L expressing human FLT3L and their use as immunotherapeutic agents against solid tumors
SG11201807051VA (en) 2016-02-25 2018-09-27 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
EP3610870A4 (en) * 2017-03-31 2020-12-09 Ogata, Hisanobu METHOD OF EXPANSION OF AN ONCOLYTIC VIRUS AND ANTI-TUMOR AGENT
WO2018209315A1 (en) 2017-05-12 2018-11-15 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
CN109554353B (zh) * 2017-09-26 2021-08-06 杭州康万达医药科技有限公司 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
JP7551496B2 (ja) 2017-10-31 2024-09-17 カリヴィル イムノセラピューティクス， インコーポレイテッド 全身送達のためのプラットフォーム腫瘍溶解性ベクター
WO2019148109A1 (en) * 2018-01-26 2019-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
CN118147029A (zh) 2018-07-11 2024-06-07 阿克蒂姆治疗有限公司 工程化的免疫刺激性细菌菌株及其用途
CN116162654A (zh) * 2018-09-15 2023-05-26 纪念斯隆凯特琳癌症中心 用于癌症免疫疗法的重组痘病毒
CN109735558B (zh) * 2018-12-12 2022-04-15 中南大学 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
CA3176660A1 (en) 2019-02-27 2020-09-03 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
KR20220082025A (ko) * 2019-10-16 2022-06-16 칼리버 임뮤노쎄라퓨틱스, 인크. 변형된 세포외 외피보유 바이러스
EP4058578A2 (en) 2019-11-12 2022-09-21 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
WO2021116943A1 (en) * 2019-12-12 2021-06-17 Ignite Immunotherapy, Inc. Variant oncolytic vaccinia virus and methods of use thereof
EP4196139A2 (en) 2020-08-12 2023-06-21 Actym Therapeutics, Inc. Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms
US20240102912A1 (en) * 2020-11-09 2024-03-28 Thrive Bioscience, Inc. Plaque counting assay method
WO2022109133A1 (en) 2020-11-19 2022-05-27 Kalivir Immunotherapeutics, Inc. Oncolytic immunotherapy by tumor micro-environment remodeling
WO2022232375A1 (en) 2021-04-30 2022-11-03 Kalivir Immunotherapeutics, Inc. Oncolytic viruses for modified mhc expression
JP2024542173A (ja) 2021-11-09 2024-11-13 アクティム・セラピューティクス・インコーポレイテッド マクロファージを処置に適している表現型に変換するための免疫刺激細菌および処置のための対象の同定のためのコンパニオン診断法

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KR20080046750A (ko) * 2000-03-24 2008-05-27 바이오스피어 메디칼 인코포레이티드 능동 색전화용 미소구
AU2003258168B2 (en) * 2002-08-12 2009-10-29 Sillajen Biotherapeutics, Inc. Methods and compositions concerning poxviruses and cancer
EP1933857A2 (en) * 2005-09-07 2008-06-25 Jennerex Biotherapeutics ULC Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses
CN103429258B (zh) * 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
SMT202400047T1 (it) * 2013-08-22 2024-03-13 Univ Pittsburgh Commonwealth Sys Higher Education Terapie immuno-oncolitiche

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CN108350434A (zh) 2018-07-31
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AU2016320355A1 (en) 2018-03-15
EP3347460A4 (en) 2019-04-10
CA2996120A1 (en) 2017-03-16
US10646524B2 (en) 2020-05-12
US20180271921A1 (en) 2018-09-27
CN108350434B (zh) 2022-06-07
KR102674362B1 (ko) 2024-06-13
WO2017043815A1 (en) 2017-03-16
KR20180066075A (ko) 2018-06-18
JP6895968B2 (ja) 2021-06-30
JP2018526450A (ja) 2018-09-13

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