HK1246292A1 - 1，3，5-三嗪衍生物及其使用方法 - Google Patents
1，3，5-三嗪衍生物及其使用方法Info
- Publication number
- HK1246292A1 HK1246292A1 HK18105822.3A HK18105822A HK1246292A1 HK 1246292 A1 HK1246292 A1 HK 1246292A1 HK 18105822 A HK18105822 A HK 18105822A HK 1246292 A1 HK1246292 A1 HK 1246292A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- same
- triazine derivative
- triazine
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510459126 | 2015-07-30 | ||
| PCT/CN2016/092254 WO2017016513A1 (zh) | 2015-07-30 | 2016-07-29 | 1,3,5-三嗪衍生物及其使用方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1246292A1 true HK1246292A1 (zh) | 2018-09-07 |
Family
ID=57884121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18105822.3A HK1246292A1 (zh) | 2015-07-30 | 2018-05-07 | 1，3，5-三嗪衍生物及其使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10745383B2 (zh) |
| EP (1) | EP3330258B1 (zh) |
| JP (1) | JP6786086B2 (zh) |
| KR (1) | KR102303011B1 (zh) |
| CN (2) | CN113307794A (zh) |
| AU (1) | AU2016299092B2 (zh) |
| CA (1) | CA2993687C (zh) |
| DK (1) | DK3330258T3 (zh) |
| ES (1) | ES2881695T3 (zh) |
| HK (1) | HK1246292A1 (zh) |
| HU (1) | HUE056537T2 (zh) |
| PT (1) | PT3330258T (zh) |
| RU (1) | RU2724333C2 (zh) |
| TW (1) | TWI722004B (zh) |
| WO (1) | WO2017016513A1 (zh) |
| ZA (1) | ZA201801301B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10961222B2 (en) | 2016-07-21 | 2021-03-30 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Chemical compound of isocitrate dehydrogenase inhibitor, and application thereof |
| US11021464B2 (en) * | 2017-01-22 | 2021-06-01 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline forms of 4-(tert-butoxyamino)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine methanesulfonic acid salt |
| CN109265444B (zh) * | 2017-07-17 | 2022-03-11 | 南京圣和药业股份有限公司 | 取代的三嗪类idh抑制剂的光学异构体及其应用 |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| CN110054615B (zh) * | 2018-01-19 | 2021-06-15 | 南京圣和药业股份有限公司 | 三嗪类idh抑制剂甲磺酸盐的晶型 |
| CN110054614B (zh) * | 2018-01-19 | 2021-12-28 | 南京圣和药业股份有限公司 | 三嗪类idh抑制剂的可药用盐及其制备方法 |
| CN110054616B (zh) * | 2018-01-19 | 2021-11-23 | 南京圣和药业股份有限公司 | 三嗪类idh抑制剂的制备方法 |
| WO2020048449A1 (zh) | 2018-09-03 | 2020-03-12 | 正大天晴药业集团股份有限公司 | 包含1,3,5-三嗪衍生物或其盐的固体药物组合物 |
| KR20210124569A (ko) * | 2020-04-03 | 2021-10-15 | 주식회사 하임바이오 | 암 치료를 위한 신규 화합물 및 이를 포함하는 조성물 |
| CN116209655A (zh) * | 2020-11-09 | 2023-06-02 | 贝达药业股份有限公司 | 突变型idh1和idh2抑制剂及其应用 |
| WO2023134686A1 (zh) * | 2022-01-11 | 2023-07-20 | 正大天晴药业集团股份有限公司 | 一种1,3,5-三嗪衍生物的制备方法 |
| WO2023174235A1 (zh) * | 2022-03-15 | 2023-09-21 | 贝达药业股份有限公司 | 突变型idh1和idh2抑制剂及其应用 |
| WO2024008138A1 (zh) * | 2022-07-07 | 2024-01-11 | 正大天晴药业集团股份有限公司 | 1,3,5-三嗪衍生物的药物组合 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1001665A (en) * | 1961-06-05 | 1965-08-18 | American Cyanamid Co | Triazine derivatives and process for their preparation |
| JP3051896B2 (ja) * | 1991-03-20 | 2000-06-12 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| US7919487B2 (en) | 2004-11-10 | 2011-04-05 | Synta Pharmaceuticals Corporation | Heteroaryl compounds |
| US20060235098A1 (en) | 2005-04-19 | 2006-10-19 | Burdeniuc Juan J | Polyurethane foams made with blowing catalyst compositions containing primary hydroxyl groups and high ethylenediamine backbones |
| US9321735B2 (en) | 2010-07-20 | 2016-04-26 | Vestaron Corporation | Insecticidal triazines and pyrimidines |
| CN115536635A (zh) * | 2012-01-06 | 2022-12-30 | 法国施维雅药厂 | 治疗活性化合物及其使用方法 |
| WO2015003360A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015017821A2 (en) | 2013-08-02 | 2015-02-05 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9975878B2 (en) | 2013-11-21 | 2018-05-22 | Ptc Therapeutics, Inc. | Substituted triazine BMI-1 inhibitors |
-
2016
- 2016-07-29 KR KR1020187005756A patent/KR102303011B1/ko active IP Right Grant
- 2016-07-29 RU RU2018105614A patent/RU2724333C2/ru active
- 2016-07-29 DK DK16829878.4T patent/DK3330258T3/da active
- 2016-07-29 HU HUE16829878A patent/HUE056537T2/hu unknown
- 2016-07-29 AU AU2016299092A patent/AU2016299092B2/en active Active
- 2016-07-29 US US15/748,795 patent/US10745383B2/en active Active
- 2016-07-29 ES ES16829878T patent/ES2881695T3/es active Active
- 2016-07-29 CN CN202110544440.3A patent/CN113307794A/zh active Pending
- 2016-07-29 JP JP2018504253A patent/JP6786086B2/ja active Active
- 2016-07-29 CN CN201680043893.5A patent/CN107922358B/zh active Active
- 2016-07-29 PT PT168298784T patent/PT3330258T/pt unknown
- 2016-07-29 WO PCT/CN2016/092254 patent/WO2017016513A1/zh active Application Filing
- 2016-07-29 EP EP16829878.4A patent/EP3330258B1/en active Active
- 2016-07-29 TW TW105124242A patent/TWI722004B/zh active
- 2016-07-29 CA CA2993687A patent/CA2993687C/en active Active
-
2018
- 2018-02-26 ZA ZA2018/01301A patent/ZA201801301B/en unknown
- 2018-05-07 HK HK18105822.3A patent/HK1246292A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113307794A (zh) | 2021-08-27 |
| BR112018001780A2 (zh) | 2018-09-11 |
| EP3330258B1 (en) | 2021-07-14 |
| ES2881695T3 (es) | 2021-11-30 |
| CN107922358A (zh) | 2018-04-17 |
| RU2018105614A3 (zh) | 2019-11-20 |
| KR102303011B1 (ko) | 2021-09-16 |
| AU2016299092A1 (en) | 2018-02-22 |
| HUE056537T2 (hu) | 2022-02-28 |
| KR20180031036A (ko) | 2018-03-27 |
| US20190062308A1 (en) | 2019-02-28 |
| RU2018105614A (ru) | 2019-08-29 |
| TW201704224A (zh) | 2017-02-01 |
| WO2017016513A1 (zh) | 2017-02-02 |
| CA2993687A1 (en) | 2017-02-02 |
| RU2724333C2 (ru) | 2020-06-23 |
| EP3330258A4 (en) | 2019-01-02 |
| US10745383B2 (en) | 2020-08-18 |
| CN107922358B (zh) | 2021-05-07 |
| JP6786086B2 (ja) | 2020-11-18 |
| AU2016299092B2 (en) | 2020-08-20 |
| CA2993687C (en) | 2023-09-26 |
| TWI722004B (zh) | 2021-03-21 |
| JP2018521104A (ja) | 2018-08-02 |
| ZA201801301B (en) | 2020-07-29 |
| PT3330258T (pt) | 2021-08-19 |
| DK3330258T3 (da) | 2021-08-16 |
| EP3330258A1 (en) | 2018-06-06 |
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