HK1244018A1 - 狂犬病毒g蛋白表位及與其特異性結合的中和狂犬病毒的結合分子 - Google Patents

狂犬病毒g蛋白表位及與其特異性結合的中和狂犬病毒的結合分子

Info

Publication number
HK1244018A1
HK1244018A1 HK18103596.2A HK18103596A HK1244018A1 HK 1244018 A1 HK1244018 A1 HK 1244018A1 HK 18103596 A HK18103596 A HK 18103596A HK 1244018 A1 HK1244018 A1 HK 1244018A1
Authority
HK
Hong Kong
Prior art keywords
rabies virus
binding molecule
binds specifically
protein epitope
neutralising binding
Prior art date
Application number
HK18103596.2A
Other languages
English (en)
Inventor
張宸在
李修泳
金皈謙
安正仙
秋敏周
Original Assignee
賽特瑞恩股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 賽特瑞恩股份有限公司 filed Critical 賽特瑞恩股份有限公司
Publication of HK1244018A1 publication Critical patent/HK1244018A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
HK18103596.2A 2015-06-10 2018-03-15 狂犬病毒g蛋白表位及與其特異性結合的中和狂犬病毒的結合分子 HK1244018A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150082284 2015-06-10
PCT/KR2016/006145 WO2016200189A1 (ko) 2015-06-10 2016-06-09 광견병 바이러스 g 단백질의 에피토프 및 이에 특이적으로 결합하는 광견병 바이러스 중화 결합 분자

Publications (1)

Publication Number Publication Date
HK1244018A1 true HK1244018A1 (zh) 2018-07-27

Family

ID=57503787

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103596.2A HK1244018A1 (zh) 2015-06-10 2018-03-15 狂犬病毒g蛋白表位及與其特異性結合的中和狂犬病毒的結合分子

Country Status (5)

Country Link
US (1) US10722571B2 (zh)
KR (1) KR101969626B1 (zh)
CN (1) CN107709360B (zh)
HK (1) HK1244018A1 (zh)
WO (1) WO2016200189A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110317267B (zh) * 2018-08-09 2020-11-20 北京智仁美博生物科技有限公司 针对狂犬病病毒的双特异性抗体及其用途
CN113501873B (zh) * 2021-07-07 2023-05-23 高光 Rbv的蛋白结合分子及其用途
CN114748618A (zh) * 2022-04-02 2022-07-15 重庆智翔金泰生物制药股份有限公司 包含针对狂犬病病毒g蛋白的双特异性抗体的药物制剂及其制备方法
WO2024036193A2 (en) * 2022-08-11 2024-02-15 Icosavax, Inc. Rabies g protein and uses thereof
CN115785281A (zh) * 2022-09-27 2023-03-14 兴盟生物医药(苏州)有限公司 含有狂犬病病毒g蛋白的融合蛋白的制备方法及应用
CN117298263A (zh) * 2023-09-27 2023-12-29 成都迈科康生物科技有限公司 一种重组狂犬病疫苗及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005023849A2 (en) 2003-09-04 2005-03-17 Crucell Holland B.V. Antigenic peptides of rabies virus and uses thereof
CA2568162C (en) * 2004-05-27 2013-04-16 Crucell Holland B.V. Binding molecules capable of neutralizing rabies virus and uses thereof
ES2453973T3 (es) * 2005-02-02 2014-04-09 University Of Massachusetts Anticuerpos humanos contra la rabia y usos de los mismos
KR20060096383A (ko) 2005-03-04 2006-09-11 주식회사 셀트리온 １ 카피 이상의 ｍａｒ ｄｎａ 서열이 유전자의전사종결영역의 3′말단에 삽입된 동물세포 발현 벡터 및그를 이용한 외래 유전자의 발현 방법
KR101495019B1 (ko) * 2011-09-30 2015-02-24 (주)셀트리온 광견병 바이러스를 중화시킬 수 있는 결합 분자
CN103374069B (zh) * 2012-04-24 2015-06-03 中国科学院上海生命科学研究院 一种抗狂犬病毒的结合分子2e1
CN105814077B (zh) * 2013-12-12 2019-07-26 赛特瑞恩股份有限公司 能够中和狂犬病毒的结合分子

Also Published As

Publication number Publication date
KR101969626B1 (ko) 2019-04-16
KR20160145508A (ko) 2016-12-20
CN107709360A (zh) 2018-02-16
CN107709360B (zh) 2021-10-19
WO2016200189A1 (ko) 2016-12-15
US10722571B2 (en) 2020-07-28
US20190022211A1 (en) 2019-01-24

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