CN110317267B - 针对狂犬病病毒的双特异性抗体及其用途 - Google Patents
针对狂犬病病毒的双特异性抗体及其用途 Download PDFInfo
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
抗体名称 | pI值 |
C11m-scFv | 7.38 |
S1C10-scFv | 7.13 |
S2A1-scFv | 6.90 |
S2E3-scFv | 6.90 |
Claims (8)
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CN202010228865.9A CN111333723B (zh) | 2018-08-09 | 2019-08-01 | 针对狂犬病病毒g蛋白的单克隆抗体及其用途 |
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CN2018109015180 | 2018-08-09 | ||
CN201810901518 | 2018-08-09 |
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CN202010228865.9A Division CN111333723B (zh) | 2018-08-09 | 2019-08-01 | 针对狂犬病病毒g蛋白的单克隆抗体及其用途 |
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CN201910706710.9A Active CN110317267B (zh) | 2018-08-09 | 2019-08-01 | 针对狂犬病病毒的双特异性抗体及其用途 |
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US (1) | US11773155B2 (zh) |
CN (2) | CN111333723B (zh) |
RU (1) | RU2764740C1 (zh) |
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WO2020029860A1 (zh) * | 2018-08-09 | 2020-02-13 | 北京智仁美博生物科技有限公司 | 针对狂犬病病毒的双特异性抗体及其用途 |
CN113416249B (zh) * | 2020-10-21 | 2023-04-07 | 北京智仁美博生物科技有限公司 | 针对破伤风毒素的组合物 |
CN115260307B (zh) * | 2021-05-08 | 2024-02-09 | 南昌大学 | 一种高亲和力抗狂犬病病毒的全人源单克隆抗体及其用途 |
CN113501873B (zh) * | 2021-07-07 | 2023-05-23 | 高光 | Rbv的蛋白结合分子及其用途 |
CN114748618B (zh) * | 2022-04-02 | 2024-07-19 | 重庆智翔金泰生物制药股份有限公司 | 包含针对狂犬病病毒g蛋白的双特异性抗体的药物制剂及其制备方法 |
WO2024036193A2 (en) * | 2022-08-11 | 2024-02-15 | Icosavax, Inc. | Rabies g protein and uses thereof |
CN115785281B (zh) * | 2022-09-27 | 2024-07-19 | 兴盟生物医药(苏州)有限公司 | 含有狂犬病病毒g蛋白的融合蛋白的制备方法及应用 |
Citations (3)
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WO2004106375A1 (en) * | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
CN102139106A (zh) * | 2004-05-27 | 2011-08-03 | 克鲁塞尔荷兰公司 | 能中和狂犬病病毒的结合分子及其应用 |
WO2018116198A1 (en) * | 2016-12-23 | 2018-06-28 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
CA2682390A1 (en) | 2007-04-17 | 2008-10-30 | Imclone Llc | Pdgfr.beta.-specific inhibitors |
WO2009147248A2 (en) | 2008-06-05 | 2009-12-10 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
WO2011080765A2 (en) * | 2010-01-04 | 2011-07-07 | Indian Immunologicals Limited | Recombinant human bivalent diabody against rabies virus and uses thereof |
WO2016073410A1 (en) * | 2014-11-03 | 2016-05-12 | Merial, Inc. | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
US10722571B2 (en) | 2015-06-10 | 2020-07-28 | Celltrion Inc. | Rabies virus G protein epitope, and rabies virus neutralising binding molecule that binds specifically thereto |
WO2020029860A1 (zh) | 2018-08-09 | 2020-02-13 | 北京智仁美博生物科技有限公司 | 针对狂犬病病毒的双特异性抗体及其用途 |
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WO2004106375A1 (en) * | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
CN102139106A (zh) * | 2004-05-27 | 2011-08-03 | 克鲁塞尔荷兰公司 | 能中和狂犬病病毒的结合分子及其应用 |
WO2018116198A1 (en) * | 2016-12-23 | 2018-06-28 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
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US20210340224A1 (en) | 2021-11-04 |
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RU2764740C1 (ru) | 2022-01-20 |
CN110317267A (zh) | 2019-10-11 |
ZA202007259B (en) | 2023-04-26 |
WO2020029860A1 (zh) | 2020-02-13 |
CN111333723A (zh) | 2020-06-26 |
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