HK1243668A1 - 在微流體裝置中濃縮顆粒 - Google Patents
在微流體裝置中濃縮顆粒Info
- Publication number
- HK1243668A1 HK1243668A1 HK18103098.5A HK18103098A HK1243668A1 HK 1243668 A1 HK1243668 A1 HK 1243668A1 HK 18103098 A HK18103098 A HK 18103098A HK 1243668 A1 HK1243668 A1 HK 1243668A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- microfluidic device
- concentrating particles
- concentrating
- particles
- microfluidic
- Prior art date
Links
- 239000002245 particle Substances 0.000 title 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462074315P | 2014-11-03 | 2014-11-03 | |
US201462074213P | 2014-11-03 | 2014-11-03 | |
PCT/US2015/058841 WO2016073486A1 (en) | 2014-11-03 | 2015-11-03 | Concentrating particles in a microfluidic device |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1243668A1 true HK1243668A1 (zh) | 2018-07-20 |
Family
ID=55851578
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103098.5A HK1243668A1 (zh) | 2014-11-03 | 2018-03-05 | 在微流體裝置中濃縮顆粒 |
HK18103107.4A HK1243669A1 (zh) | 2014-11-03 | 2018-03-05 | 分選微流體裝置中的顆粒 |
HK18103108.3A HK1243765A1 (zh) | 2014-11-03 | 2018-03-05 | 在微流體裝置中對顆粒的聯合分選和濃縮 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103107.4A HK1243669A1 (zh) | 2014-11-03 | 2018-03-05 | 分選微流體裝置中的顆粒 |
HK18103108.3A HK1243765A1 (zh) | 2014-11-03 | 2018-03-05 | 在微流體裝置中對顆粒的聯合分選和濃縮 |
Country Status (7)
Country | Link |
---|---|
US (11) | US9610582B2 (zh) |
EP (5) | EP3215270B1 (zh) |
JP (4) | JP6649377B2 (zh) |
CN (3) | CN107110766B (zh) |
CA (3) | CA2966623C (zh) |
HK (3) | HK1243668A1 (zh) |
WO (3) | WO2016073486A1 (zh) |
Families Citing this family (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US8186913B2 (en) * | 2007-04-16 | 2012-05-29 | The General Hospital Corporation | Systems and methods for particle focusing in microchannels |
US9068181B2 (en) * | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
US9427688B2 (en) * | 2008-07-10 | 2016-08-30 | Steven H. Reichenbach | Method and apparatus for sorting particles using asymmetrical particle shifting |
US8691145B2 (en) | 2009-11-16 | 2014-04-08 | Flodesign Sonics, Inc. | Ultrasound and acoustophoresis for water purification |
US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US9783775B2 (en) | 2012-03-15 | 2017-10-10 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9796956B2 (en) | 2013-11-06 | 2017-10-24 | Flodesign Sonics, Inc. | Multi-stage acoustophoresis device |
US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
US9272234B2 (en) | 2012-03-15 | 2016-03-01 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US9567559B2 (en) | 2012-03-15 | 2017-02-14 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
US10370635B2 (en) | 2012-03-15 | 2019-08-06 | Flodesign Sonics, Inc. | Acoustic separation of T cells |
US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
US10564147B2 (en) | 2012-05-25 | 2020-02-18 | The Regents Of The University Of California | Microfluidic systems for particle trapping and separation using cavity acoustic transducers |
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
CA2942831A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Princeton University | Methods and devices for high throughput purification |
US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
AU2015243445B2 (en) | 2014-04-10 | 2020-05-28 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
EP3213414B1 (en) | 2014-10-28 | 2020-07-22 | Massachusetts Institute of Technology | Simultaneous oscillation and frequency tracking of multiple resonances via digitally implemented phase-locked loop array |
EP3215270B1 (en) | 2014-11-03 | 2020-05-27 | The General Hospital Corporation | Concentrating particles in a microfluidic device |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
SG11201706777QA (en) | 2015-02-19 | 2017-09-28 | Premium Genetics (Uk) Ltd | Scanning infrared measurement system |
US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
EP3288660A1 (en) | 2015-04-29 | 2018-03-07 | Flodesign Sonics Inc. | Acoustophoretic device for angled wave particle deflection |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
US9862941B2 (en) | 2015-10-14 | 2018-01-09 | Pioneer Hi-Bred International, Inc. | Single cell microfluidic device |
US11154860B2 (en) * | 2015-10-23 | 2021-10-26 | Unist (Ulsan National Institute Of Science & Technology) | Centrifugal force-based nanoparticle separation apparatus and method for separating nanoparticles using the same |
KR101791671B1 (ko) * | 2015-12-31 | 2017-11-20 | 주식회사 큐리오시스 | 미세입자 분리 및 정렬 장치, 및 그 방법 |
KR101855490B1 (ko) * | 2016-01-22 | 2018-05-08 | 한국과학기술원 | 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법 |
US10710006B2 (en) | 2016-04-25 | 2020-07-14 | Flodesign Sonics, Inc. | Piezoelectric transducer for generation of an acoustic standing wave |
WO2017192760A1 (en) | 2016-05-03 | 2017-11-09 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
WO2017197343A2 (en) * | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
WO2017221258A1 (en) * | 2016-06-23 | 2017-12-28 | B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Method and device for chemiluminescence-based analysis |
GB2553898B (en) * | 2016-07-12 | 2021-04-07 | Emulate Inc | Additive channels |
US10094776B2 (en) * | 2016-07-18 | 2018-10-09 | Honeywell International Inc. | Dust sensor with mass separation fluid channels and fan control |
CA3032340A1 (en) * | 2016-08-02 | 2018-02-08 | Imec Vzw | Method and arrangement for focusing objects in a flow |
US10010883B2 (en) * | 2016-09-20 | 2018-07-03 | International Business Machines Corporation | Deterministic lateral displacement arrays |
WO2018071448A1 (en) | 2016-10-11 | 2018-04-19 | The Regents Of The University Of California | Systems and methods to encapsulate and preserve organic matter for analysis |
EP3529347A1 (en) | 2016-10-19 | 2019-08-28 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
US11384327B2 (en) | 2016-11-01 | 2022-07-12 | California Institute Of Technology | Microfluidic devices and methods for purifying rare antigen-specific T cell populations |
CN106823474B (zh) * | 2017-02-07 | 2023-01-24 | 重庆科技学院 | 一种血液分流器的使用方法 |
CN106823475B (zh) * | 2017-02-07 | 2023-01-24 | 重庆科技学院 | 一种血液分流器 |
JP2020513798A (ja) * | 2017-03-17 | 2020-05-21 | イスタンブール・テクニック・ユニヴェルシテシIstanbul Teknik Universitesi | ガン細胞の血液からの連続的分離および循環系でのその豊富化のための非対称カールにより構成されるらせん形状を有するマイクロチャネル |
US11213824B2 (en) | 2017-03-29 | 2022-01-04 | The Research Foundation For The State University Of New York | Microfluidic device and methods |
WO2018179841A1 (ja) * | 2017-03-31 | 2018-10-04 | ソニー株式会社 | 微粒子捕捉装置、微粒子捕捉システムおよび微粒子捕捉方法 |
US11162886B2 (en) | 2017-03-31 | 2021-11-02 | Massachusetts Institute Of Technology | Systems, articles, and methods for flowing particles |
EP3631415A4 (en) | 2017-06-02 | 2021-02-24 | The General Hospital Corporation | OSCILLATORY FOCUSING OF PARTICLES IN CHANNELS |
WO2018227210A1 (en) | 2017-06-09 | 2018-12-13 | The Regents Of The University Of California | High-efficiency encapsulation in droplets based on hydrodynamic vortices control |
WO2018227204A1 (en) * | 2017-06-09 | 2018-12-13 | The Regents Of The University Of California | Controlled encapsulation in droplets by liquid-liquid interfacial shearing |
US11517901B2 (en) | 2017-06-09 | 2022-12-06 | The Regents Of The University Of California | High-efficiency particle encapsulation in droplets with particle spacing and downstream droplet sorting |
WO2018236708A1 (en) | 2017-06-19 | 2018-12-27 | Massachusetts Institute Of Technology | SYSTEMS AND METHODS FOR MEASURING PARTICLE PROPERTIES |
EP3669163A4 (en) * | 2017-08-04 | 2021-08-11 | University of Georgia Research Foundation, Inc. | DEVICES AND METHODS FOR SEPARATING CIRCULATING TUMOR CELLS FROM BIOLOGICAL SAMPLES |
US11648559B2 (en) | 2017-08-04 | 2023-05-16 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating circulating tumor cells from biological samples |
US11292000B2 (en) | 2017-08-04 | 2022-04-05 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating circulating tumor cells from biological samples |
US10969324B2 (en) * | 2017-08-16 | 2021-04-06 | Washington University | Synthesis, post-modification and separation of biologics using acoustically confined substrates |
EP3675876A4 (en) | 2017-09-01 | 2021-06-02 | GPB Scientific, Inc. | PROCESSES FOR PREPARING THERAPEUTICALLY ACTIVE CELLS USING MICROFLUIDICS |
WO2019075409A1 (en) | 2017-10-12 | 2019-04-18 | The Regents Of The University Of California | ISOLATION AND IDENTIFICATION WITHOUT MICROFLUIDIC LABEL OF CELLS USING FLUORESCENCE LIFE IMAGING (FLIM) |
US11499127B2 (en) | 2017-10-20 | 2022-11-15 | The Regents Of The University Of California | Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks |
US11745179B2 (en) | 2017-10-20 | 2023-09-05 | The Regents Of The University Of California | Microfluidic systems and methods for lipoplex-mediated cell transfection |
US10930381B2 (en) | 2017-11-10 | 2021-02-23 | Reliant Immune Diagnostics, Inc. | Microfluidic testing system for mobile veterinary applications |
US11527324B2 (en) | 2017-11-10 | 2022-12-13 | Reliant Immune Diagnostics, Inc. | Artificial intelligence response system based on testing with parallel/serial dual microfluidic chip |
US10930380B2 (en) | 2017-11-10 | 2021-02-23 | Reliant Immune Diagnostics, Inc. | Communication loop and record loop system for parallel/serial dual microfluidic chip |
US11200986B2 (en) | 2017-11-10 | 2021-12-14 | Reliant Immune Diagnostics, Inc. | Database and machine learning in response to parallel serial dual microfluidic chip |
US11124821B2 (en) | 2017-11-10 | 2021-09-21 | Reliant Immune Diagnostics, Inc. | Microfluidic testing system with cell capture/analysis regions for processing in a parallel and serial manner |
US11041185B2 (en) * | 2017-11-10 | 2021-06-22 | Reliant Immune Diagnostics, Inc. | Modular parallel/serial dual microfluidic chip |
AU2018385759B2 (en) | 2017-12-14 | 2021-10-21 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
US20190226953A1 (en) | 2018-01-19 | 2019-07-25 | International Business Machines Corporation | Microscale and mesoscale condenser devices |
US10946380B2 (en) * | 2018-01-19 | 2021-03-16 | International Business Machines Corporation | Microfluidic chips for particle purification and fractionation |
US11458474B2 (en) | 2018-01-19 | 2022-10-04 | International Business Machines Corporation | Microfluidic chips with one or more vias |
WO2019195620A1 (en) * | 2018-04-04 | 2019-10-10 | The General Hospital Corporation | Microfluidic systems and methods to denude mammalian oocytes |
BR112020023607A2 (pt) | 2018-05-23 | 2021-02-17 | Abs Global, Inc. | sistemas e métodos para focalização de partículas em microcanais |
IT201800006083A1 (it) * | 2018-06-06 | 2019-12-06 | Dispositivo microfluidico per la concentrazione di particelle tramite centrifugazione, e relativo dispositivo di centrifugazione e/o rilevazione | |
US11192110B2 (en) | 2018-07-06 | 2021-12-07 | Liu Lian | Methods and systems for cell-based non-invasive prenatal testing |
CN108927232B (zh) * | 2018-07-17 | 2020-12-01 | 博奥生物集团有限公司 | 一种针对微流控芯片的流体混匀结构 |
KR102083845B1 (ko) * | 2018-07-31 | 2020-03-03 | 광주과학기술원 | 혈액 진단 소자 |
WO2020032970A1 (en) | 2018-08-10 | 2020-02-13 | Hewlett-Packard Development Company, L.P. | Serial cellular analytics |
CN111068799B (zh) * | 2018-10-18 | 2021-03-23 | 浙江达普生物科技有限公司 | 用于产生液滴的微流体通路及其应用 |
US11162143B2 (en) | 2018-10-21 | 2021-11-02 | The University Of Kansas | Methods for generating therapeutic delivery platforms |
EP3902630A1 (en) * | 2018-11-15 | 2021-11-03 | Massachusetts Institute of Technology | Multi-dimensional double spiral device and methods of use thereof |
WO2020146741A1 (en) | 2019-01-10 | 2020-07-16 | Selim Olcum | Calibration of a functional biomarker instrument |
CN109550531B (zh) * | 2019-01-28 | 2021-09-07 | 武汉纺织大学 | 一种磁性尺寸依赖的微流控芯片 |
EP3955735A4 (en) | 2019-04-18 | 2023-01-25 | ABS Global, Inc. | SYSTEM AND METHOD FOR CONTINUOUSLY ADDING CRYOPROTECTOR |
EP3747541B1 (en) * | 2019-06-03 | 2024-02-07 | Cellular Highways Ltd. | Apparatus for sorting microfluidic particles |
US11841365B2 (en) * | 2019-07-16 | 2023-12-12 | University Of Georgia Research Foundation, Inc. | Devices, kits, and methods for label-free focusing and/or separation of sub-micron particles |
US20210016273A1 (en) * | 2019-07-19 | 2021-01-21 | University Of Utah Research Foundation | Rapid sperm separation based on sperm morphology and motility |
CN111909828A (zh) | 2019-07-23 | 2020-11-10 | 北京大学 | 一种适用于循环肿瘤细胞捕获的微流控芯片 |
US11255769B2 (en) | 2019-08-01 | 2022-02-22 | International Business Machines Corporation | Up-concentration and size sorting of nanoparticles in microfluidic devices |
US11919002B2 (en) | 2019-08-20 | 2024-03-05 | 10X Genomics, Inc. | Devices and methods for generating and recovering droplets |
CN110465339B (zh) * | 2019-09-03 | 2021-02-09 | 浙江大学 | 一种流固两相输运中颗粒定位的方法 |
US20210109094A1 (en) * | 2019-10-11 | 2021-04-15 | Case Western Reserve University | Detection of disease components using magnetic particles and microfluidics |
CN112779118A (zh) * | 2019-11-07 | 2021-05-11 | 北京机械设备研究所 | 一种循环肿瘤细胞正向分离系统 |
WO2021102134A1 (en) | 2019-11-20 | 2021-05-27 | E Ink Corporation | Spatially variable hydrophobic layers for digital microfluidics |
BR112022010371A2 (pt) * | 2019-11-29 | 2022-08-16 | Donaldson Co Inc | Sistemas e métodos para separar partículas em fluidos |
US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
WO2021146573A1 (en) | 2020-01-17 | 2021-07-22 | E Ink Corporation | Spatially variable dielectric layers for digital microfluidics |
WO2021154627A1 (en) | 2020-01-27 | 2021-08-05 | E Ink Corporation | Method for degassing liquid droplets by electrowetting actuation at higher temperatures |
US11410620B2 (en) | 2020-02-18 | 2022-08-09 | Nuclera Nucleics Ltd. | Adaptive gate driving for high frequency AC driving of EWoD arrays |
CN115135413A (zh) | 2020-02-19 | 2022-09-30 | 核酸有限公司 | 用于EWoD阵列的高频AC驱动的锁存晶体管驱动 |
US20230146950A1 (en) * | 2020-04-02 | 2023-05-11 | Weibin LIANG | Deterministic lateral displacement array with a single column of bumping obstacles |
WO2021222061A1 (en) | 2020-04-27 | 2021-11-04 | Nuclera Nucleics Ltd. | Segmented top plate for variable driving and short protection for digital microfluidics |
EP4178721A1 (en) * | 2020-07-08 | 2023-05-17 | Lumacyte, Inc. | Sampling device and systems |
CN113109107B (zh) * | 2021-03-24 | 2022-06-07 | 西安交通大学 | 一种气溶胶颗粒的富集装置 |
CN113275047A (zh) * | 2021-04-30 | 2021-08-20 | 北京机械设备研究所 | 微流控芯片及其用途 |
WO2023041948A1 (en) * | 2021-09-15 | 2023-03-23 | Fundación Para La Investigación Médica Aplicada | Device suitable for exchanging a liquid medium and selecting particles in a mixture |
WO2023245000A2 (en) * | 2022-06-13 | 2023-12-21 | Russell Van De Casteele | Methods for processing, enrichment, delivery, formulation, uptake and testing for supplements and pharmaceuticals |
CN115337967B (zh) * | 2022-07-08 | 2024-04-02 | 南方科技大学 | 分离芯片 |
US11772025B1 (en) | 2022-08-02 | 2023-10-03 | W. L. Gore & Associates, Inc. | Industrial filter assembly enhancement |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4164597A (en) * | 1996-08-26 | 1998-03-19 | Princeton University | Reversibly sealable microstructure sorting devices |
US5968820A (en) | 1997-02-26 | 1999-10-19 | The Cleveland Clinic Foundation | Method for magnetically separating cells into fractionated flow streams |
US6540896B1 (en) | 1998-08-05 | 2003-04-01 | Caliper Technologies Corp. | Open-Field serial to parallel converter |
DK1169062T3 (da) | 1999-04-09 | 2010-01-25 | Amag Pharmaceuticals Inc | Varmestabile overtrukne kolloide jernoxider |
FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN1444646A (zh) * | 2000-02-23 | 2003-09-24 | 齐翁米克斯股份有限公司 | 具有凸起的样品表面的芯片 |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
US20020187503A1 (en) * | 2001-05-02 | 2002-12-12 | Michael Harrold | Concentration and purification of analytes using electric fields |
AU2002320058A1 (en) | 2001-06-06 | 2002-12-16 | The General Hspital Corporation | Magnetic-nanoparticle conjugates and methods of use |
AU2003207438A1 (en) | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
US7560267B2 (en) * | 2002-03-18 | 2009-07-14 | City University Of Hong Kong | Apparatus and methods for on-chip monitoring of cellular reactions |
JP4799861B2 (ja) | 2002-04-16 | 2011-10-26 | プリンストン ユニバーシティ | マイクロ流体とナノ流体間のインターフェース用勾配構造と、その製造方法および使用方法 |
US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
AU2003233498A1 (en) * | 2002-06-10 | 2003-12-22 | Phynexus, Inc. | Biomolecule open channel solid phase extraction systems and methods |
WO2003103836A1 (en) | 2002-06-11 | 2003-12-18 | Kionix, Inc. | Methods and devices for microfluidic extraction |
US7699767B2 (en) * | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
WO2004037374A2 (en) * | 2002-10-23 | 2004-05-06 | The Trustees Of Princeton University | Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields |
JP4075765B2 (ja) * | 2002-10-30 | 2008-04-16 | 日本電気株式会社 | 分離装置およびその製造方法、ならびに分析システム |
JP2004354364A (ja) * | 2002-12-02 | 2004-12-16 | Nec Corp | 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法 |
US20050072677A1 (en) | 2003-02-18 | 2005-04-07 | Board Of Regents, The University Of Texas System | Dielectric particle focusing |
US20060068490A1 (en) * | 2004-03-05 | 2006-03-30 | Cha-Mei Tang | Flow-through chemical and biological sensor |
US7968287B2 (en) * | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
WO2006108087A2 (en) * | 2005-04-05 | 2006-10-12 | Cellpoint Diagnostics | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
WO2006110458A1 (en) | 2005-04-08 | 2006-10-19 | Velocys, Inc. | Flow control through plural, parallel connecting channels to/from a manifold |
CA2606924C (en) | 2005-05-09 | 2013-04-16 | The General Hospital Corporation | Water relaxation-based sensors |
US20070026419A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059781A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
JP2007196219A (ja) * | 2005-12-28 | 2007-08-09 | Kawamura Inst Of Chem Res | 物質分離デバイスおよび物質分離方法 |
US7735652B2 (en) * | 2006-06-01 | 2010-06-15 | The Trustees Of Princeton University | Apparatus and method for continuous particle separation |
EP2134471A2 (en) * | 2007-04-06 | 2009-12-23 | California Institute of Technology | Microfluidic device |
US7837040B2 (en) | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
US8186913B2 (en) * | 2007-04-16 | 2012-05-29 | The General Hospital Corporation | Systems and methods for particle focusing in microchannels |
WO2009045551A1 (en) | 2007-10-04 | 2009-04-09 | The General Hospital Corporation | Miniaturized magnetic resonance systems and methods |
FI20085299A0 (fi) | 2008-04-10 | 2008-04-10 | Valtion Teknillinen | Mikrofluidistisia siruvälineitä ja niiden käyttö |
US9427688B2 (en) * | 2008-07-10 | 2016-08-30 | Steven H. Reichenbach | Method and apparatus for sorting particles using asymmetrical particle shifting |
WO2010011934A2 (en) | 2008-07-24 | 2010-01-28 | The Trustees Of Princeton University | Bump array device having asymmetric gaps for segregation of particles |
WO2010123594A2 (en) * | 2009-01-15 | 2010-10-28 | Children's Medical Center Corporation | Device for filtration of fluids there through and accompanying method |
EP2421628A4 (en) | 2009-04-23 | 2012-10-10 | Logos Energy Inc | LATERAL DISPLACEMENT ARRANGEMENT FOR MICROFILTRATION |
RU2539989C2 (ru) * | 2009-12-23 | 2015-01-27 | Сайтовера, Инк. | Система и способ фильтрации частиц |
ITTO20100068U1 (it) * | 2010-04-20 | 2011-10-21 | Eltek Spa | Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici |
WO2012016136A2 (en) * | 2010-07-30 | 2012-02-02 | The General Hospital Corporation | Microscale and nanoscale structures for manipulating particles |
US9522344B2 (en) * | 2010-11-18 | 2016-12-20 | The Regents Of The University Of California | Method and device for high-throughput solution exchange for cell and particle suspension |
WO2012103391A2 (en) | 2011-01-28 | 2012-08-02 | Dow Agrosciences Llc | Insescticidal composition and processes related thereto |
JP2012223683A (ja) * | 2011-04-18 | 2012-11-15 | Seiko Epson Corp | 微粒子分離装置および微粒子分離方法 |
EP2739394A2 (en) | 2011-08-04 | 2014-06-11 | Sage Science, Inc. | Microfluidic systems and methods for processing fluids |
US20140227777A1 (en) * | 2011-09-30 | 2014-08-14 | Brigham And Women's Hospital | Cell sorting by 3d flow and adhesive rolling |
US9149806B2 (en) | 2012-01-10 | 2015-10-06 | Biopico Systems Inc | Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics |
CN104540594B (zh) | 2012-06-25 | 2019-07-02 | 通用医疗公司 | 使用高梯度磁场对粒子进行分类 |
WO2014052968A1 (en) | 2012-09-28 | 2014-04-03 | Canon U.S. Life Sciences, Inc. | Particle separation and concentration using spiral inertial filtration |
CA2887341C (en) * | 2012-10-12 | 2021-03-16 | Sage Science, Inc. | Side-eluting molecular fractionator |
US9795965B2 (en) | 2013-01-03 | 2017-10-24 | Brigham And Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
CA2942831A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Princeton University | Methods and devices for high throughput purification |
US20140342375A1 (en) * | 2013-03-15 | 2014-11-20 | University Of Maryland | Microfluidic processing of leukocytes for molecular diagnostic testing |
US20170209864A1 (en) | 2013-03-15 | 2017-07-27 | Gpb Scientific, Llc | Methods and systems for processing particles |
US20200353470A1 (en) * | 2013-10-01 | 2020-11-12 | Owl biomedical, Inc. | Particle manipulation system with multisort valve and focusing element |
CA2937486A1 (en) * | 2014-01-20 | 2015-07-23 | Halcyon Biomedical, Incorporated | Passive separation of whole blood |
US10307760B2 (en) | 2014-01-30 | 2019-06-04 | The General Hospital Corporation | Inertio-elastic focusing of particles in microchannels |
EP3177904A4 (en) | 2014-08-07 | 2018-01-03 | The General Hospital Corporation | Platelet-targeted microfluidic isolation of cells |
EP3215270B1 (en) * | 2014-11-03 | 2020-05-27 | The General Hospital Corporation | Concentrating particles in a microfluidic device |
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