HK1222661A1 - 吡喃葡萄糖基取代的吲哚脲衍生物及其作為 抑制劑的用途 - Google Patents

吡喃葡萄糖基取代的吲哚脲衍生物及其作為 抑制劑的用途

Info

Publication number
HK1222661A1
HK1222661A1 HK16110670.8A HK16110670A HK1222661A1 HK 1222661 A1 HK1222661 A1 HK 1222661A1 HK 16110670 A HK16110670 A HK 16110670A HK 1222661 A1 HK1222661 A1 HK 1222661A1
Authority
HK
Hong Kong
Prior art keywords
sglt
glucopyranosyl
urea derivatives
substituted indole
inhibitors
Prior art date
Application number
HK16110670.8A
Other languages
English (en)
Inventor
Todd Fields
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1222661A1 publication Critical patent/HK1222661A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044Pyrrole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK16110670.8A 2013-11-01 2016-09-08 吡喃葡萄糖基取代的吲哚脲衍生物及其作為 抑制劑的用途 HK1222661A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361898494P 2013-11-01 2013-11-01
PCT/US2014/062548 WO2015065956A1 (en) 2013-11-01 2014-10-28 Glucopyranosyl-substituted indole-urea derivatives and their use as sglt inhibitors

Publications (1)

Publication Number Publication Date
HK1222661A1 true HK1222661A1 (zh) 2017-07-07

Family

ID=51862614

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16110670.8A HK1222661A1 (zh) 2013-11-01 2016-09-08 吡喃葡萄糖基取代的吲哚脲衍生物及其作為 抑制劑的用途

Country Status (39)

Country Link
US (1) US9145437B2 (zh)
EP (1) EP3063162B1 (zh)
JP (1) JP6147429B2 (zh)
KR (1) KR101838826B1 (zh)
CN (1) CN105636972B (zh)
AP (1) AP2016009137A0 (zh)
AR (1) AR098134A1 (zh)
AU (1) AU2014342612B2 (zh)
BR (1) BR112016008704B1 (zh)
CA (1) CA2924516C (zh)
CL (1) CL2016000988A1 (zh)
CR (1) CR20160146A (zh)
CY (1) CY1119540T1 (zh)
DK (1) DK3063162T3 (zh)
DO (1) DOP2016000062A (zh)
EA (1) EA029516B1 (zh)
ES (1) ES2646125T3 (zh)
HK (1) HK1222661A1 (zh)
HR (1) HRP20171514T1 (zh)
HU (1) HUE034689T2 (zh)
IL (1) IL244896B (zh)
JO (1) JO3298B1 (zh)
LT (1) LT3063162T (zh)
MA (1) MA38991B1 (zh)
ME (1) ME02839B (zh)
MX (1) MX2016005428A (zh)
NO (1) NO3099623T3 (zh)
NZ (1) NZ717880A (zh)
PE (1) PE20160663A1 (zh)
PH (1) PH12016500809B1 (zh)
PL (1) PL3063162T3 (zh)
PT (1) PT3063162T (zh)
RS (1) RS56417B1 (zh)
SG (1) SG11201602950UA (zh)
SI (1) SI3063162T1 (zh)
TN (1) TN2016000125A1 (zh)
TW (1) TWI657093B (zh)
UA (1) UA117137C2 (zh)
WO (1) WO2015065956A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110128493B (zh) * 2018-02-08 2021-01-12 亚宝药业集团股份有限公司 吡喃糖取代杂环化合物的盐及其制备方法和用途
WO2024055932A1 (zh) * 2022-09-13 2024-03-21 亚宝药业集团股份有限公司 氮杂环化合物、其药物组合物和用于预防和/或治疗疾病的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200501094B (en) * 2002-08-08 2006-10-25 Kissei Pharmaceutical Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
ZA200501549B (en) * 2002-08-23 2006-07-26 Kissei Pharmaceutical Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof and intermediate for the production thereof
EP1803729A4 (en) 2004-09-29 2008-10-01 Kissei Pharmaceutical HETEROCYCLIC NITROGENIC COMPOUND 1- (-D-GLYCOPYRANOSYL) -3-SUBSTITUTED, THERAPEUTIC PREPARATION CONTAINING SAID COMPOUND, AND MEDICAL USE OF SAID COMPOUND
CA2588963C (en) 2004-11-18 2013-06-25 Kissei Pharmaceutical Co., Ltd. 1-substituted-3-.beta.-d-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same
TWI418556B (zh) * 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp 吲哚衍生物
UA113086C2 (xx) 2012-05-10 2016-12-12 Піразольні сполуки як інгібітори sglt1
TW201425326A (zh) * 2012-10-05 2014-07-01 Lilly Co Eli 新穎脲化合物

Also Published As

Publication number Publication date
TWI657093B (zh) 2019-04-21
CA2924516A1 (en) 2015-05-07
EP3063162A1 (en) 2016-09-07
IL244896A0 (en) 2016-05-31
EP3063162B1 (en) 2017-08-16
JO3298B1 (ar) 2018-09-16
PL3063162T3 (pl) 2018-01-31
HRP20171514T1 (hr) 2017-11-17
AU2014342612B2 (en) 2016-09-29
CR20160146A (es) 2016-05-30
TW201609784A (zh) 2016-03-16
HUE034689T2 (hu) 2018-02-28
LT3063162T (lt) 2017-10-25
EA201690593A1 (ru) 2016-08-31
CN105636972B (zh) 2018-05-22
WO2015065956A1 (en) 2015-05-07
EA029516B1 (ru) 2018-04-30
PH12016500809A1 (en) 2016-06-13
CL2016000988A1 (es) 2016-11-11
RS56417B1 (sr) 2018-01-31
CY1119540T1 (el) 2018-03-07
KR101838826B1 (ko) 2018-03-14
CN105636972A (zh) 2016-06-01
BR112016008704A8 (pt) 2020-03-17
SG11201602950UA (en) 2016-05-30
DK3063162T3 (en) 2017-10-02
IL244896B (en) 2019-02-28
MA38991B1 (fr) 2018-09-28
ES2646125T3 (es) 2017-12-12
BR112016008704B1 (pt) 2022-11-29
JP2016535032A (ja) 2016-11-10
AU2014342612A1 (en) 2016-03-31
US9145437B2 (en) 2015-09-29
AR098134A1 (es) 2016-05-04
CA2924516C (en) 2019-09-10
PT3063162T (pt) 2017-11-14
MA38991A1 (fr) 2017-11-30
NZ717880A (en) 2017-12-22
JP6147429B2 (ja) 2017-06-14
UA117137C2 (uk) 2018-06-25
DOP2016000062A (es) 2016-03-31
PE20160663A1 (es) 2016-07-09
US20150126469A1 (en) 2015-05-07
NO3099623T3 (zh) 2018-04-21
KR20160060138A (ko) 2016-05-27
ME02839B (me) 2018-01-20
AP2016009137A0 (en) 2016-04-30
TN2016000125A1 (en) 2017-10-06
PH12016500809B1 (en) 2016-06-13
MX2016005428A (es) 2016-08-11
SI3063162T1 (sl) 2017-10-30

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