PT3466431T - Formas cristalinas e métodos para preparação de inibidores de sglt2 - Google Patents
Formas cristalinas e métodos para preparação de inibidores de sglt2Info
- Publication number
- PT3466431T PT3466431T PT182016329T PT18201632T PT3466431T PT 3466431 T PT3466431 T PT 3466431T PT 182016329 T PT182016329 T PT 182016329T PT 18201632 T PT18201632 T PT 18201632T PT 3466431 T PT3466431 T PT 3466431T
- Authority
- PT
- Portugal
- Prior art keywords
- methods
- crystalline forms
- sglt2 inhibitors
- preparing
- preparing sglt2
- Prior art date
Links
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/42—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361783128P | 2013-03-14 | 2013-03-14 | |
US201361887504P | 2013-10-07 | 2013-10-07 | |
US201361912252P | 2013-12-05 | 2013-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3466431T true PT3466431T (pt) | 2024-01-26 |
Family
ID=51625112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT182016329T PT3466431T (pt) | 2013-03-14 | 2014-03-10 | Formas cristalinas e métodos para preparação de inibidores de sglt2 |
Country Status (5)
Country | Link |
---|---|
US (1) | US9573959B2 (pt) |
EP (2) | EP3466431B1 (pt) |
ES (2) | ES2969245T3 (pt) |
PT (1) | PT3466431T (pt) |
WO (1) | WO2014159151A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2969245T3 (es) | 2013-03-14 | 2024-05-17 | Msd Int Gmbh | Formas cristalinas y métodos para preparar inhibidores de SGLT2 |
PE20170024A1 (es) | 2014-05-19 | 2017-03-17 | Pfizer | Compuestos de 6,8-dioxabiciclo [3.2.1] octano-2,3-diol sustituidos como agentes de direccionamiento al asgpr |
EP3303345A4 (en) * | 2015-05-25 | 2019-01-30 | Sun Pharmaceutical Industries Ltd | ERTUGLIFOZINE CO-CRYSTALS AND PROCESS FOR PREPARING THEM |
WO2017134606A1 (en) * | 2016-02-05 | 2017-08-10 | Sun Pharmaceutical Industries Limited | Crystalline form of {(1r,2s,3s,4r,5s)-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-2,3,4-trihydroxy-6,8-dioxabicyclo[3.2.1]oct-1-yl}methyl acetate |
CN105646604A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 埃格列净晶型b及制备方法 |
CN107382952B (zh) * | 2017-07-13 | 2020-02-28 | 杭州科巢生物科技有限公司 | 埃格列净的制备方法及其中间体 |
CN107857768A (zh) * | 2018-01-04 | 2018-03-30 | 威海贯标信息科技有限公司 | 一种埃格列净新晶型 |
CN111566112B (zh) * | 2018-03-06 | 2022-02-15 | 广东东阳光药业有限公司 | 埃格列净的晶型及其制备方法 |
EP3810623A1 (en) | 2018-06-25 | 2021-04-28 | Pharmathen S.A. | A novel process for the preparation of sglt-2 inhibitors |
WO2020026273A1 (en) * | 2018-07-31 | 2020-02-06 | Msn Laboratories Private Limited, R&D Center | Solid forms of ertugliflozin free base and solid dispersions comprising ertugliflozin l-pyroglutamic acid. |
CN113195510B (zh) * | 2019-01-08 | 2022-12-23 | 宜昌东阳光长江药业股份有限公司 | 吡喃葡萄糖基衍生物的制备方法及其中间体 |
EP4114365A1 (en) | 2020-03-05 | 2023-01-11 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising sglt2 inhibitor |
EP4161912A1 (en) | 2020-06-05 | 2023-04-12 | KRKA, d.d., Novo mesto | Preparation of highly pure amorphous dapagliflozin |
WO2021260498A1 (en) * | 2020-06-22 | 2021-12-30 | Aurobindo Pharma Limited | An improved purification process for the preparation of ertugliflozin and ertugliflozin l-pyroglutamic acid co-crystal |
WO2022007838A1 (en) * | 2020-07-08 | 2022-01-13 | Dongguan Hec New Drug R & D Co., Ltd. | Method for preparing glucopyranosyl derivatives and intermediates thereof |
EP4206212A4 (en) | 2020-09-30 | 2024-05-22 | Beijing Creatron Institute Of Pharmaceutical Res Co Ltd | SGLT-2 AND SARCOSINE INHIBITOR COCRYSTAL, PROCESS FOR PREPARATION THEREFOR AND USE THEREOF |
CN114163425A (zh) * | 2021-12-20 | 2022-03-11 | 江西天戌药业有限公司 | 一种恩格列净杂质的制备方法与应用 |
CN117430571A (zh) * | 2022-07-15 | 2024-01-23 | 宜昌东阳光长江药业股份有限公司 | 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法 |
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CN102372722A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
ES2969245T3 (es) | 2013-03-14 | 2024-05-17 | Msd Int Gmbh | Formas cristalinas y métodos para preparar inhibidores de SGLT2 |
-
2014
- 2014-03-10 ES ES18201632T patent/ES2969245T3/es active Active
- 2014-03-10 PT PT182016329T patent/PT3466431T/pt unknown
- 2014-03-10 US US14/777,560 patent/US9573959B2/en active Active
- 2014-03-10 ES ES14773353T patent/ES2740299T3/es active Active
- 2014-03-10 EP EP18201632.9A patent/EP3466431B1/en active Active
- 2014-03-10 WO PCT/US2014/022243 patent/WO2014159151A1/en active Application Filing
- 2014-03-10 EP EP14773353.9A patent/EP2968375B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2968375A4 (en) | 2016-08-03 |
EP3466431A1 (en) | 2019-04-10 |
US9573959B2 (en) | 2017-02-21 |
ES2740299T3 (es) | 2020-02-05 |
WO2014159151A1 (en) | 2014-10-02 |
US20160046646A1 (en) | 2016-02-18 |
ES2969245T3 (es) | 2024-05-17 |
EP2968375B1 (en) | 2019-06-12 |
EP2968375A1 (en) | 2016-01-20 |
EP3466431B1 (en) | 2023-11-15 |
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