HK1221214A1 - 二吡咯亞甲基的結晶及其製備方法 - Google Patents

二吡咯亞甲基的結晶及其製備方法

Info

Publication number
HK1221214A1
HK1221214A1 HK16109149.3A HK16109149A HK1221214A1 HK 1221214 A1 HK1221214 A1 HK 1221214A1 HK 16109149 A HK16109149 A HK 16109149A HK 1221214 A1 HK1221214 A1 HK 1221214A1
Authority
HK
Hong Kong
Prior art keywords
dipyrromethene
crystal
manufacturing same
manufacturing
same
Prior art date
Application number
HK16109149.3A
Other languages
English (en)
Inventor
仁 渡邊
隆弘 岡地
倫明 川原
大史 長澤
仙忠 佐藤
崇 瀧田
玄 長谷川
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of HK1221214A1 publication Critical patent/HK1221214A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16109149.3A 2013-04-10 2016-08-01 二吡咯亞甲基的結晶及其製備方法 HK1221214A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013081879 2013-04-10
PCT/JP2014/060055 WO2014168103A1 (ja) 2013-04-10 2014-04-07 ピロール誘導体の結晶及びその製造方法

Publications (1)

Publication Number Publication Date
HK1221214A1 true HK1221214A1 (zh) 2017-05-26

Family

ID=51689511

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16109149.3A HK1221214A1 (zh) 2013-04-10 2016-08-01 二吡咯亞甲基的結晶及其製備方法

Country Status (13)

Country Link
US (3) US9499483B2 (zh)
EP (2) EP2985277B1 (zh)
JP (2) JP6240164B2 (zh)
KR (2) KR102234597B1 (zh)
CN (2) CN105164105B (zh)
BR (1) BR112015025729B1 (zh)
CA (2) CA2958625C (zh)
ES (2) ES2661125T3 (zh)
HK (1) HK1221214A1 (zh)
HU (2) HUE038950T2 (zh)
IL (2) IL241892B (zh)
TW (1) TWI624447B (zh)
WO (1) WO2014168103A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6422871B2 (ja) 2013-08-27 2018-11-14 第一三共株式会社 ピロール誘導体の製造方法及びその中間体
EP3434284A4 (en) * 2016-03-24 2019-11-13 Daiichi Sankyo Company, Limited MEDICINE FOR THE TREATMENT OF KIDNEY DISEASE
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
WO2021132438A1 (ja) * 2019-12-25 2021-07-01 第一三共株式会社 ピロールカルボキサミドを含む口腔内崩壊錠
US20230029044A1 (en) * 2020-02-21 2023-01-26 Sumitomo Pharma Co., Ltd. Optically resolved trolox intermediate and method for producing same
CA3213094A1 (en) * 2021-03-30 2022-10-06 Qiao ZONG Crystalline form of pyrrole amide compound, preparation method therefor and use thereof
US20240239746A1 (en) * 2021-04-26 2024-07-18 Sunshine Lake Pharma Co., Ltd. Preparation method for pyrrole amide compound
CN113651745B (zh) * 2021-09-09 2023-06-02 上海医药工业研究院 布瓦西坦中间体及其制备方法和纯化方法
CN115784961A (zh) * 2021-09-10 2023-03-14 上海鼎雅药物化学科技有限公司 埃沙西林酮及其中间体的合成方法
CN118541351A (zh) * 2022-01-14 2024-08-23 广东东阳光药业股份有限公司 制备吡咯化合物的方法及其中间体
CN114456098B (zh) * 2022-01-19 2024-06-14 大连理工大学 糖尿病肾病药物艾莎利酮的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―4―オン誘導体の製造方法
EP1248869A2 (en) * 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
PT1773768T (pt) 2004-07-30 2018-11-30 Exelixis Inc Derivados de pirrol como agentes farmacêuticos
CN101006052B (zh) * 2004-07-30 2013-11-06 埃克塞利希斯股份有限公司 作为药用制剂的吡咯衍生物
KR100770434B1 (ko) 2006-11-07 2007-10-26 여석준 다층 다단 다공성 플레이트에 의한 입자 분리·포집시스템
KR20140048337A (ko) 2007-04-09 2014-04-23 다이이찌 산쿄 가부시키가이샤 피롤 유도체의 아트로프 이성체
JP2010111657A (ja) * 2008-10-07 2010-05-20 Daiichi Sankyo Co Ltd ピロール誘導体のアトロプ異性体を含有する医薬
WO2010098286A1 (ja) * 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬

Also Published As

Publication number Publication date
HUE038950T2 (hu) 2018-12-28
US20170233341A1 (en) 2017-08-17
EP2985277B1 (en) 2018-01-17
ES2700962T3 (es) 2019-02-20
IL260782B (en) 2019-02-28
US9499483B2 (en) 2016-11-22
CN105164105B (zh) 2018-01-30
ES2661125T3 (es) 2018-03-27
US20160096803A1 (en) 2016-04-07
KR20210018557A (ko) 2021-02-17
CA2958625C (en) 2019-05-28
CN105164105A (zh) 2015-12-16
JP2017141274A (ja) 2017-08-17
BR112015025729B1 (pt) 2023-04-25
EP3190102B1 (en) 2018-09-12
JPWO2014168103A1 (ja) 2017-02-16
EP2985277A1 (en) 2016-02-17
CA2908879A1 (en) 2014-10-16
CN106916092B (zh) 2019-07-19
CA2908879C (en) 2018-05-15
EP2985277A4 (en) 2016-11-23
US9776961B2 (en) 2017-10-03
TWI624447B (zh) 2018-05-21
HUE041725T2 (hu) 2019-05-28
IL241892B (en) 2020-02-27
US20170057915A1 (en) 2017-03-02
TW201518253A (zh) 2015-05-16
JP6511083B2 (ja) 2019-05-15
KR20150139854A (ko) 2015-12-14
EP3190102A1 (en) 2017-07-12
KR102234597B1 (ko) 2021-03-31
CN106916092A (zh) 2017-07-04
BR112015025729A2 (pt) 2017-07-18
CA2958625A1 (en) 2014-10-16
JP6240164B2 (ja) 2017-11-29
WO2014168103A1 (ja) 2014-10-16
US9676713B2 (en) 2017-06-13

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