HK1215950A1 - 异源二聚免疫球蛋白的纯化 - Google Patents

异源二聚免疫球蛋白的纯化 Download PDF

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Publication number
HK1215950A1
HK1215950A1 HK16103843.5A HK16103843A HK1215950A1 HK 1215950 A1 HK1215950 A1 HK 1215950A1 HK 16103843 A HK16103843 A HK 16103843A HK 1215950 A1 HK1215950 A1 HK 1215950A1
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HK
Hong Kong
Prior art keywords
immunoglobulin
region
fragment
amino acid
protein
Prior art date
Application number
HK16103843.5A
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English (en)
Chinese (zh)
Inventor
斯坦尼斯拉斯‧布蘭
斯坦尼斯拉斯‧布兰
法布里齊奧‧康珀
法布里齐奥‧康珀
羅曼‧奧利耶
罗曼‧奥利耶
保羅‧瓦斯曼
保罗‧瓦斯曼
Original Assignee
艾科诺斯科技股份有限公司
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Publication of HK1215950A1 publication Critical patent/HK1215950A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK16103843.5A 2012-09-25 2013-09-25 异源二聚免疫球蛋白的纯化 HK1215950A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261705278P 2012-09-25 2012-09-25
US61/705,278 2012-09-25
PCT/EP2013/069989 WO2014049003A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Publications (1)

Publication Number Publication Date
HK1215950A1 true HK1215950A1 (zh) 2016-09-30

Family

ID=49237223

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16103843.5A HK1215950A1 (zh) 2012-09-25 2013-09-25 异源二聚免疫球蛋白的纯化

Country Status (11)

Country Link
US (2) US20150239991A1 (https=)
EP (2) EP3401337A1 (https=)
JP (5) JP2015529236A (https=)
KR (1) KR20150076172A (https=)
CN (1) CN104968685A (https=)
AU (2) AU2013322710A1 (https=)
CA (2) CA2886036A1 (https=)
HK (1) HK1215950A1 (https=)
IL (2) IL237872B (https=)
IN (1) IN2015MN00139A (https=)
WO (1) WO2014049003A1 (https=)

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CN104968685A (zh) 2015-10-07
JP2020105203A (ja) 2020-07-09
CA3061557A1 (en) 2014-04-03
JP2018104444A (ja) 2018-07-05
KR20150076172A (ko) 2015-07-06
AU2018204314A1 (en) 2018-07-05
AU2013322710A1 (en) 2015-04-16
CA2886036A1 (en) 2014-04-03
JP2015529236A (ja) 2015-10-05
JP2019073512A (ja) 2019-05-16
AU2018204314B2 (en) 2020-05-14
EP3401337A1 (en) 2018-11-14
IN2015MN00139A (https=) 2015-10-16
JP6856610B2 (ja) 2021-04-07
IL237872A0 (en) 2015-05-31
IL237872B (en) 2019-09-26
EP2900696A1 (en) 2015-08-05
US20150239991A1 (en) 2015-08-27
US20200010568A1 (en) 2020-01-09
AU2013322710A2 (en) 2015-05-07
IL269207B (en) 2022-02-01
JP2022116326A (ja) 2022-08-09
WO2014049003A1 (en) 2014-04-03
IL269207A (en) 2019-11-28

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