HK1214769A1 - 用於治療神經退行性變疾病的α-突出核蛋白和其疫苗的模擬表位 - Google Patents

用於治療神經退行性變疾病的α-突出核蛋白和其疫苗的模擬表位

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Publication number
HK1214769A1
HK1214769A1 HK16102825.9A HK16102825A HK1214769A1 HK 1214769 A1 HK1214769 A1 HK 1214769A1 HK 16102825 A HK16102825 A HK 16102825A HK 1214769 A1 HK1214769 A1 HK 1214769A1
Authority
HK
Hong Kong
Prior art keywords
mimotopes
vaccines
treatment
neurodegenerative disorders
alpha synuclein
Prior art date
Application number
HK16102825.9A
Other languages
English (en)
Inventor
馬庫斯‧曼德勒
哈拉爾德‧溫寧格
拉德米勒‧桑蒂克
埃迪斯‧科皮尼茨
Original Assignee
Affiris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affiris Ag filed Critical Affiris Ag
Publication of HK1214769A1 publication Critical patent/HK1214769A1/zh

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HK16102825.9A 2008-02-22 2016-03-11 用於治療神經退行性變疾病的α-突出核蛋白和其疫苗的模擬表位 HK1214769A1 (zh)

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AT0029708A AT506535B1 (de) 2008-02-22 2008-02-22 Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden

Publications (1)

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HK1214769A1 true HK1214769A1 (zh) 2016-08-05

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HK16102825.9A HK1214769A1 (zh) 2008-02-22 2016-03-11 用於治療神經退行性變疾病的α-突出核蛋白和其疫苗的模擬表位
HK18104829.9A HK1245136A1 (zh) 2008-02-22 2018-04-13 用於治療神經退行性變疾病的α-突出核蛋白和其疫苗的模擬表位

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HK18104829.9A HK1245136A1 (zh) 2008-02-22 2018-04-13 用於治療神經退行性變疾病的α-突出核蛋白和其疫苗的模擬表位

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US (4) US9724399B2 (zh)
EP (3) EP3388074B1 (zh)
JP (4) JP5804707B2 (zh)
KR (1) KR101627763B1 (zh)
CN (4) CN107261133A (zh)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009536157A (ja) 2006-04-13 2009-10-08 ペプチミューン，インコーポレイテッド エピトープ透過性の指向された拡張を介した指向性配列ポリマー組成物の設計方法および合成方法
AP3467A (en) 2007-10-16 2015-11-30 Peptimmune Inc Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
AT506535B1 (de) * 2008-02-22 2010-04-15 Affiris Forschungs & Entwicklungs Gmbh Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden
WO2009128948A1 (en) 2008-04-17 2009-10-22 Peptimmune, Inc. Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
EP2949666B1 (en) 2008-12-19 2018-12-19 Biogen International Neuroscience GmbH Human anti-alpha-synuclein antibodies
AU2012272790B2 (en) * 2011-06-23 2016-10-06 Biogen International Neuroscience Gmbh Anti-alpha synuclein binding molecules
ES2496341T3 (es) 2011-10-04 2014-09-18 Affiris Ag Procedimiento para detectar anticuerpos Aß-específicos en una muestra biológica
CA2863953A1 (en) * 2012-01-27 2013-08-01 Neotope Biosciences Limited Humanized antibodies that recognize alpha-synuclein
EP2659907A1 (en) * 2012-05-01 2013-11-06 Affiris AG Compositions
EP2659906A1 (en) 2012-05-01 2013-11-06 Affiris AG Compositions
KR102358311B1 (ko) * 2013-11-21 2022-02-08 에프. 호프만-라 로슈 아게 항-알파-시누클레인 항체 및 사용 방법
WO2016005545A1 (en) * 2014-07-10 2016-01-14 Affiris Ag Substances and methods for the use in prevention and/or treatment in huntington's disease
JP6684524B2 (ja) * 2015-03-09 2020-04-22 イミューン モジュレーション，インク． 神経変性疾患の処置または予防のためのハイポエストキシド、その誘導体、関連化合物、およびアゴニスト
WO2017076873A1 (en) 2015-11-03 2017-05-11 Affiris Ag Method for vaccination against a self-antigen in a human patient
JP6968839B2 (ja) * 2016-06-29 2021-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California α−シヌクレイン凝集の構造ベースペプチド阻害剤
TWI644673B (zh) * 2017-07-27 2018-12-21 百朗克股份有限公司 頭孢曲松的用途
AU2021322080A1 (en) 2020-08-04 2023-02-23 Ac Immune Sa Immunogenic compounds
EP4357354A1 (en) 2021-06-18 2024-04-24 Sumitomo Pharma Co., Ltd. Epitope peptide of human alpha-synuclein and pharmaceutical composition including said peptide
WO2023152260A1 (en) 2022-02-09 2023-08-17 Ac Immune Sa Anti-alpha-synuclein therapeutic vaccines
WO2023161526A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN
WO2023161527A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN
AT525943A2 (de) * 2022-02-28 2023-09-15 Tridem Bioscience Gmbh & Co Kg Konjugat bestehend aus oder umfassend zumindest ein ß-Glucan oder ein Mannan

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170229A1 (en) * 1999-02-25 2003-09-11 Smithkline Beecham Biologicals S.A. Vaccine
US8106174B2 (en) * 2000-05-08 2012-01-31 Monsanto Technology Llc Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US7834146B2 (en) * 2000-05-08 2010-11-16 Monsanto Technology Llc Recombinant polypeptides associated with plants
KR20030085528A (ko) * 2001-02-07 2003-11-05 앵스띠뛰 파스퇴르 포토랍두스 루미네센스 균주 ｔｔ01 게놈 및 그 용도
JP4863341B2 (ja) * 2001-09-06 2012-01-25 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ヒラメラブドウイルス感染魚類用ｄｎａワクチン
US7479482B2 (en) 2001-11-21 2009-01-20 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid β, prion protein, amylin, α-synuclein, or polyglutamine repeats for induction of an immune response thereto
GB0216972D0 (en) * 2002-07-22 2002-08-28 Univ Lancaster Peptides and peptide derivaties for the treatment of &-synuclein-related diseases
US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US9034337B2 (en) * 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) * 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
WO2004089369A2 (en) * 2003-04-11 2004-10-21 Cambridge University Technical Services Limited Methods and means for treating protein conformational disorders
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
HUE034320T2 (en) 2003-05-19 2018-02-28 Prothena Biosciences Ltd Truncated fragments of alpha-synuclein in lewy-body disease
WO2004113535A1 (ja) 2003-06-22 2004-12-29 Koji Sode 凝集抑制作用を有するシヌクレイン変異体
CA2588423A1 (en) * 2004-11-17 2006-05-26 Joanne Mclaurin Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation
CN101142482A (zh) * 2005-02-25 2008-03-12 阿拉巴马大学董事会 蛋白错误折叠和聚集的调节因子及其使用方法
CA2598792A1 (en) * 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
KR20080019619A (ko) * 2005-05-18 2008-03-04 맥시겐, 인크. 개량된 인터페론-알파 폴리펩티드
KR20080108416A (ko) * 2006-01-19 2008-12-15 암브룩스, 인코포레이티드 조절된 면역원성을 갖는 비천연 아미노산 폴리펩티드
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
EP1993523A4 (en) * 2006-02-17 2009-06-10 Joanne Mclaurin COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS
CA2670405A1 (en) * 2006-11-24 2008-05-29 Waratah Pharmaceuticals Inc. Combination treatments for alzheimer's disease and related neurodegenerative diseases
US20120142902A1 (en) * 2007-02-23 2012-06-07 The Regents Of The University Of California Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US8147833B2 (en) * 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
PL2118300T3 (pl) * 2007-02-23 2015-11-30 Prothena Biosciences Ltd Zapobieganie i leczenie synukleinopatii i amyloidozy
AT505574B1 (de) * 2007-08-10 2009-09-15 Affiris Forschungs & Entwicklungs Gmbh Mimotope zur behandlung von atherosklerose
AT506535B1 (de) * 2008-02-22 2010-04-15 Affiris Forschungs & Entwicklungs Gmbh Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics

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